Fragilysin, the enterotoxin from Bacteroides fragilis, enhances the serum antibody response to antigen co-administered by the intranasal route

Vaccine

Volumn 19, Issue 6, 2000, Pages 655-660

  Vines, Richard R ^a   Perdue, Samuel S ^a   Moncrief, J Scott ^a   Sentz, Danielle R ^a   Barroso, Lisa A ^a   Wright, Rhonda L ^a   Wilkins, Tracy D ^a  

^a Fralin Life Science Institute   (United States)

Author keywords

Enterotoxigenic Bacteroides fragilis; Fragilysin; Intranasal adjuvant

Indexed keywords

ADAMALYSIN; ADJUVANT; CELL PROTEIN; CHOLERA TOXIN; FRAGILYSIN; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN G; METALLOPROTEINASE; OVALBUMIN; UNCLASSIFIED DRUG;

ANAEROBIC BACTERIUM; ANIMAL EXPERIMENT; ANTIBODY BLOOD LEVEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTEROIDES FRAGILIS; CONTROLLED STUDY; DRUG MECHANISM; EPITHELIUM CELL; FEMALE; IMMUNIZATION; MOUSE; NONHUMAN; NOSE MUCOSA; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN DEGRADATION; SECRETION;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; ANIMALS; ANIMALS, OUTBRED STRAINS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; CHOLERA TOXIN; FEMALE; IMMUNITY, MUCOSAL; IMMUNOGLOBULINS; METALLOENDOPEPTIDASES; MICE; MICE, INBRED BALB C; OVALBUMIN; VACCINATION;

EID: 0034623670     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(00)00254-1     Document Type: Article

References (35)

1. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen
2. Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin
3. Some current concepts in intestinal bacteriology
4. Bacteroides fragilis subspecies in clinical isolates
5. Virulence factors in anaerobic bacteria
6. Bacteroides fragilis: a possible cause of acute diarrheal disease in newborn lambs
7. Association of enterotoxigenic Bacteroides fragilis with diarrheal disease in calves
8. Enumeration of enterotoxigenic Bacteroides fragilis in municipal sewage
9. Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo
10. Tight junctions and the molecular basis for regulation of paracellular permeability
11. Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebing on HT-29 cells
12. Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis
13. Bacteroides fragilis toxin rapidly intoxicates human intestinal epithelial cells (HT29/C1) in vitro
14. Bacteroides fragilis toxin rearranges the actin cytoskeleton of HT29/C1 cells without direct proteolysis of the actin or decrease in F-actin content
15. The Bacteroides fragilis toxin fragilysin disrupts the paracellular barrier of epithelial cells
16. Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin
17. Regulation of the movement of solutes across tight junctions
18. Bacteroides fragilis toxin 2 damages human colonic mucosa in vitro
19. Molecular modeling and analysis of fragilysin, the Bacteroides fragilis toxin
20. New mucosal adjuvants for Helicobacter pylori vaccines
21. Zonula occludens toxin is a powerful mucosal adjuvant for intranasally delivered antigens
22. Purification and characterization of an enterotoxin from Bacteroides fragilis
23. Human colonic epithelial cells, HT-29/C1, treated with crude Bacteroides fragilis enterotoxin dramatically alter their morphology
24. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4
25. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity
26. Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'
27. The metzincins - topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a super family of zinc-peptidases
28. Matrix metalloproteinases: structures, evolution, and diversification
29. The enterotoxin of Bacteroides fragilis is a metalloprotease
30. The adjuvant action of cholera toxin is associated with an increased intestinal permeability for luminal antigens
31. Stimulation of the transepithelial flux of influenza HA vaccine by cholera toxin B subunit
32. Gangliosides and membrane receptors for cholera toxin
33. Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions
34. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro
35. Modulation of intestinal permeability: an innovative method of oral drug delivery for the treatment of inherited and acquired human diseases