Change of bone tissue composition and impaired bone strength in rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126)

Toxicology

Volumn 150, Issue 1-3, 2000, Pages 41-51

  Lind, P M ^a   Larsson, S ^b   Oxlund, H ^c   Hakansson H ^d   Nyberg, K ^a   Eklund, T ^b   Orberg J ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c AARHUS UNIVERSITY   (Denmark)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

3,3',4,4',5 Pentachlorobiphenyl; B one strength; Collagen; Cross links; PCB126; Rat; Stiffness; Vitamin A

Indexed keywords

3,3',4,4',5 PENTACHLOROBIPHENYL; COLLAGEN; ESTROGEN; ETHOXYRESORUFIN DEETHYLASE; HYDROXYPROLINE; PYRIDINOLINE; RETINOIC ACID; RETINOL; RETINOL PALMITATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BODY WEIGHT; BONE MINERAL; BONE STRENGTH; COLLAGEN SYNTHESIS; CONTROLLED STUDY; FEMALE; FEMUR; FRACTURE; HUMERUS; KIDNEY MASS; LIVER WEIGHT; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT; RIGIDITY; TORQUE; VITAMIN BLOOD LEVEL; WATER CONTENT;

ANIMALS; BIOMECHANICS; BONE AND BONES; COLLAGEN; ENVIRONMENTAL POLLUTANTS; FEMALE; ORGAN SIZE; OVARIECTOMY; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; VITAMIN A;

EID: 0034618567     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00245-6     Document Type: Article

References (48)

1. Andrews J.E. Polychlorinated biphenyl (Arochlor 1254) induced changes in femur morphometry calcium metabolism and nephrotoxicity. Toxicology. 57:(1):1989;83-96.
2. Andrews J.E., Courtney K.D., Stead A.G., Donaldson W.E. Hexachlorobenzene-induced hyperparathyroidism and osteosclerosis in rats. Fundam. Appl. Toxicol. 12:(2):1989;242-251.
3. Andrews J.E., Jackson L.D., Stead A.G., Donaldson W.E. Morphometric analysis of osteosclerotic bone resulting from hexachlorobenzene exposure. J. Toxicol. Environ. Health. 31:(3):1990;193-201.
4. Astroff B., Safe S. 2,3,7,8-tetrachlorodibenzo-p-dioxin as an antiestrogen: effect on rat uterine peroxidase activity. Biochem. Pharmacol. 39:(3):1990;485-488.
5. Béland P., DeGuise S., Girard C., Lagacé A., Martineau D., Michaud R., Muir D.C.G., Norstrom R.L., Pelletier É., Ray S., Shugart L.R. Toxic compounds and health and reproductive effects in St. Lawrence beluga whales. J. Great Lakes Res. 19:(4):1993;766-775.
6. Bengtsson B.E., Bengtsson Å., Himberg M. Fish deformities and pollution in some swedish waters. Ambio. 14:(1):1985;32-35.
7. Bergman A., Olsson M., Reiland S. Skull-bone lesions in the Baltic grey seal (Halichoerus grypus). Ambio. 21:(8):1992;517-520.
8. Biegel L., Safe S. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on cell growth and the secretion of the estrogen-induced 34-, 52- and 160-kDa proteins in human breast cancer cells. J. Steroid Biochem. Mol. Biol. 37:1990;725-732.
9. Burstein A.H., Frankel V.H. A standard test for laboratory animal bone. J. Biomech. 4:(2):1971;155-158.
10. Chu I., Villenvue D.C., Yagminas A., LeCavalier P., Poons R., Feeley M., Kennedy S.W., Seegal R.F., Håkansson H., Ahlborg U.G., Valli V.E. Subcronic toxicity of 3,3′,4,4′,5-pentachlorobiphenyl in the rat. Fundam. Appl. Toxicol. 22:1994;457-468.
11. De Guise S., Lagace A., Beland P., Girard C., Higgins R. Non-neoplastic lesions in beluga whales (Delphinapterus leucas) and other marine mammals from the St. Lawrence estuary. J. Comp. Pathol. 112:(3):1995;257-271.
12. De Luca F., Uyeda J.A., Mericq V., Mancilla E.E., Jack A., Yanovski J.A., Barnes K.M., Zile M.H., Jeffrey L. Retinoic acid is a potent regulator of growth plate chondrogenesis. Endocrinology. 141:(1):2000;346-353.
13. Fex G.A., Larsson K., Nihlsson-Ehle I. Serum concentrations of all-trans and 13-cis retinoic acid and retinol are closely related. J. Nutr. Biochem. 7:1996;162-165.
14. Gierthy J.F., Silkworth J.B., Tassinari M., Stein G.S., Lian J.B. 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits differentiation of normal diploid rat osteoblasts in vitro. J. Cell. Biochem. 54:(2):1994;231-238.
15. Gierthy J.F., Aracaro K.F., Floyd M. Assessment of PCB estrogenicity in a human breast cancer cell line. Chemosphere. 34:(5-7):1997;1495-1505.
16. Gruber K.A., O'Brien L.V., Gerstner R. Vitamin A: not required for adrenal steroidogenesis in rats. Science. 191:1976;472-475.
17. Haag-Grönlund M., Johansson N., Fransson-Steen R., Hakansson H., Scheu G., Warngard L. Interactive effects of three structurally different polychlorinated biphenyls in a rat liver tumor promotion bioassay. Toxicol. Appl. Pharmacol. 152:(1):1998;153-165.
18. Håkansson H. The role of retinoids in dioxin toxicity. Organohalogen Compounds. 34:1997;402-405.
19. Håkansson H., Ahlborg U.G. The effect of 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) on the uptake, distribution and excretion of a single oral dose of [11,12-3H] retinyl acetate and on the Vitamin A status in the rat. J. Nutr. 115:1985;759-771.
20. Håkansson H., Johansson L., Manzoor E., Ahlborg U.G. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the vitamin A status of Hartley guinea pigs, Sprague-Dawley rats, C57B1/6 mice, DBA/2 mice, and Golden Syrian hamsters. J. Nutr. Sci. Vitaminol. 37:(2):1991;117-138.
21. Hough S., Avioli L.V., Muir H., Gelderblom D., Jenkins G., Kurasi H., Slatopolsky E., Bergfeld M.A., Teitelbaum S.L. Effects of hypervitaminosis A on the bone and mineral metabolism of the rat. Endocrinology. 122:(6):1988;2933-2939.
22. Kimbrough R.D. The toxicity of polychlorinated polycyclic compounds and related chemicals. CRC Crit. Rev. Toxicol. 2:(4):1974;445-498.
23. Krishnan V., Safe S.H. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationship. Toxicol. Appl. Pharmacol. 120:1993;55-61.
24. Lepola V., Vaananen K., Jalovaara P. The effect of immobilization on the torsional strength of the rat tibia. Clin. Orthop. 297:1993;55-61.
25. Lind P.M., Bergman A., Olsson M., Örberg J. Bone density in Baltic grey seal. Acta Orthop. Scand. 70:(Suppl. 287):1999a;112.
26. Lind P.M., Eriksen E.F., Sahlin L., Edlund M., Örberg J. Effects of the antiestrogenic environmental pollutant 3,3′,4,4′,5-pentachlorobiphenyl (PCB #126) in rat bone and uterus: diverging effects in ovariectomized and intact animals. Toxicol. Appl. Pharmacol. 154:(3):1999b;236-244.
27. Melhus H., Michaelsson K., Kindmark A., Bergstrom R., Holmberg L., Mallmin H., Wolk A., Ljunghall S. Excessive dietary intake of vitamin A is associated with reduced bone mineral density and increased risk for hip fracture. Ann. Intern. Med. 129:(10):1998;770-778.
28. Mellanby E. Skeletal changes affecting the nervous system produced in young dogs by diets deficient in Vitamin A. J. Physiol. 99:1941;467-486.
29. Mellanby E. Nutrition in relation to bone growth and the nervous system. Proc. R. Soc. Ser. B. 132:1944;28-45.
30. Melton L.J.d. Hip fractures: a worldwide problem today and tomorrow. Bone. 14:(Suppl. 1):1993;S1-S8.
31. Melton L.J. III. How many women have osteoporosis now? J. Bone Miner. Res. 10:(2):1995;175-177.
32. Moore T., Wang Y.L. Hypervitaminosis A. Biochem. J. 39:1945;222-228.
33. Neuman R.E., Logan M.A. The determination of collagen and elastin in tissues. J. Biol. Chem. 186:1950;549-556.
34. Nilsson C.B., Hanberg A., Trossvik C., Håkansson H. 2,3,7,8-Tetrachlorodibenzo-p-dioxin affects retinol esterification in rat hepatic stellate cells and kidneys. Environ. Toxicol. Pharmacol. 2:1996;17-23.
35. Olsson M., Karlsson B., Ahnland E. Diseases and environmental contaminants in seals from the Baltic and Swedish west coast. Sci. Total Environ. 154:1994;217-227.
36. Oxlund H., Barckman M., Ørtoft G., Andreassen T.T. Reduced concentrations of collagen cross-links are associated with reduced strength of bone. Bone. 17:(Suppl. 4):1995;365-371.
37. Oxlund H., Mosekilde L., Ørtoft G. Reduced concentration of collagen reducible crosslinks in human trabecular bone with respect to age and osteoporosis. Bone. 19:(5):1996;479-484.
38. Pohjanvirta R., Håkansson H., Juvonen R., Tuomisto J. Effects of TCDD on vitamin A status and liver microsomal enzyme activities in a TCDD-susceptible and a TCDD-resistant rat strain. Food. Chem. Toxicol. 28:(3):1990;197-203.
39. Rodahl K. Hypervitaminosis A and scurvy. Nature. 164:1949;531.
40. Schwartz T.R., Tillitt D.E., Feltz K.P., Peterman P.H. Determination of mono- and non-o,o′-chlorine substituted polychlorinated biphenyls in arochlors and environmental samples. Chemosphere. 26:1993;1443-1460.
41. Strömberg L., Dalen N. Experimental measurement of maximum torque capacity of long bones. Acta Orthop. Scand. 47:(3):1976;257-263.
42. Thunberg T., Ahlborg U.G., Johnsson H. Vitamin A (retinol) status in the rat after a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Toxicol. 42:(4):1979;265-274.
43. WHO, 1994. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ. Tech. Rep. Ser. 843, 1-129.
44. Woessner J.F. Determination of hydroxyprolin in connective tissues. Hall D.A. The Methodology of Connective Tissue Research Oxford. 1976;227-233 Joynson-Bruvvers, Oxford.
45. Wolf G. Vitamin A. Alfin-Slater R.B., et al. Nutrition and the Adult: Micronutrients. Human Nutrition, A Comprehensive Treatise. 1980;97-203 Plenum Press, New York.
46. Wolf G. Multiple functions of vitamin A. Physiol. Rev. 64:1984;873-937.
47. Wyss R., Bücheli F. Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching: I. Determination of isotretinoin and tretinoin and their 4-oxo metabolites in plasma. J. Chromatogr. B Biomed. Appl. 424:(2):1988;303-314.
48. Zile M.H. Vitamin A homeostasis endangered by environmental pollutants. Proc. Soc. Exp. Biol. Med. 201:1992;141-153.