Interactive effects of three structurally different polychlorinated biphenyls in a rat liver tumor promotion bioassay

Toxicology and Applied Pharmacology

Volumn 152, Issue 1, 1998, Pages 153-165

  Haag Grönlund, Marie ^a   Johansson, Niklas ^a,b   Fransson Steen, Ronny ^c   Håkansson, Helen ^a   Scheu, Gunilla ^a   Wärngård, Lars ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWEDISH ENVIRONMENTAL PROTECTION AGENCY   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; 2,3,3',4,4' PENTACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYTOCHROME P450; DIETHYLNITROSAMINE; ETHOXYRESORUFIN; GAMMA GLUTAMYLTRANSFERASE; PENTOXYRESORUFIN; POLYCHLORINATED BIPHENYL; RETINOID; RETINOL; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; LIVER TUMOR; LIVER WEIGHT; MULTIVARIATE ANALYSIS; NONHUMAN; PARTIAL HEPATECTOMY; RAT; RISK ASSESSMENT; TUMOR PROMOTION;

EID: 0344404211     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8480     Document Type: Article

References (64)

1. Ahlborg, U. G., Becking, G. C., Birnbaum, L. S., Brouwer, A., Derks, H. J. G. M., Feely, M., Golor, G., Hanberg, A., Larsen, J. C., Liem, A. K. D., Safe, S. H., Schlatter, C., Waern, F., Younes, M., and Yrjänheikki, E. (1994). Toxic equivalency factors for dioxin-like PCBs, Report on a WHO-ECEH and IPCS consultation, December 1993. Chemosphere 28(6), 1049-1067.
2. Ahlborg, U. G., Hanberg, A., and Kenne, K. (1992). Risk Assessment of Polychlorinated Biphenyls (PCBs). Nord 1992:26, Nordic Council of Ministers, ISBN 9291200751.
3. Bager, Y., Hemming, H., Flodström, S., Ahlborg, U. G., and Wärngård, L. (1995). Interaction of 3,4,5,3′,4′-pentachlorobiphenyl and 2,4,5,2′,4′,5′-hexachlorobiphenyl in promotion of altered hepatic foci in rats. Pharmacol. Toxicol. 77, 149-154.
4. Bank, P. A., Cullum, M. E., Jensen, R. K., and Zile, M. H. (1989). Effect of hexachlorobiphenyl on vitamin A homeostasis in the rat. Biochim. Biophys. Acta 990, 306-314.
5. Bannister, R., and Safe, S. (1987). Synergistic interactions of 2,3,7,8-TCDD and 2,2′,4,4′,5,5′-hexachlorobiphenyl in C57BL/6J and DBA/2J mice: Role of the Ah-receptor. Toxicology 44, 159-169.
6. Berberian, I., Chen, L.-C., Robinson, F. R., Glauert, H. P., Chow, C. K., and Robertson, L. W. (1995). Effect of dietary retinyl palmitate on the promotion of altered hepatic foci by 3,3′,4,4′-tetrachlorobiphenyl and 2,2′,4,4′,5,5′-hexachlorobiphenyl in rats initiated with diethylnitrosamine. Carcinogenesis 16(2), 393-398.
7. 14C-labelled and unlabeled coplanar polychlorinated biphenyls (PCBs). Acta Chem. Scand. 44, 1071-1076.
8. 43 expression at the post-transcriptional level in rat liver epithelial cells. Cell Biochem. Funct. 13, 69-77.
9. Biegel, L., Harris, M., Davis, D., Rosengren, R., Safe, L., and Safe, S. (1989). 2,2′,4,4′,5,5′-hexachlorobiphenyl as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist in C57BL/6J mice. Toxicol. Appl. Pharmacol. 97, 561-571.
10. Birnbaum, L. S., Weber, H., Harris, M. W., Lamb, IV, J. C., and McKinney, J. D. (1985). Toxic interaction of specific polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin: Increased incidence of cleft palate in mice. Toxicol. Appl. Pharmacol. 77, 292-302.
11. Chen, L.-C., Berberian, I., Koch, B., Mercier, M., Azais-Braesco, V., Glauert, H. P., Chow, C. K., and Robertson, L. W. (1992). Polychlorinated and polybrominated biphenyl congeners and retinoid levels in rat tissues: Structure-activity relationships. Toxicol. Appl. Pharamacol. 114, 47-55.
12. Chu, I., Villeneuve, D. C., Yagminas, A., LeCavalier, P., Håkansson, H., Ahlborg, U. G., Valli, V. E., Kennedy, S. W., Bergman, Å., Seegal, R. F., and Feely, M. (1995). Toxicity of PCB77 (3,3′,4,4′-tetrachlorobiphenyl) and PCB 118 (2,3′,4,4′,5-pentachlorobiphenyl) in the rat following subchronic dietary exposure. Fundam. Appl. Toxicol. 26, 282-292.
13. Chu, I., Villeneuve, D. C., Yagminas, A., LeCavalier, P., Poon, R., Feely, M., Kennedy, S. W., Seegal, R. F., Håkansson, H., Ahlborg, U. G., and Valli, V. E. (1994). Subchronic toxicity of 3,3′,4,4′,5-pentachlorobiphenyl in the rat. I. Clinical, biochemical, hematological, and histopathological changes. Fundam. Appl. Toxicol. 22, 457-468.
14. Chu, I., Villeneuve, D. C., Yagminas, A., LeCavalier, P., Poon, R., Feely, M., Kennedy, S. W., Seegal, R. F., Håkansson, H., Ahlborg, U. G., Valli, V. E., and Bergman, Å. (1996). Toxicity of 2,2′,4,4′,5,5′-hexachlorobiphenyl in rats: Effects following 90-day oral exposure. J. Appl. Toxicol. 16(2), 121-128.
15. Cohen, S. M., Wittenberg, J. F., and Bryan, G. T. (1976). Effect of A-vitaminosis A and hypervitaminosis A on urinary bladder carcinogenicity of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide. Cancer Res. 36, 2334-2339.
16. De Jongh, J., DeVito, M., Diliberto, J., Van den Berg, M., and Birnbaum, L. (1995). The effects of 2,2′,4,4′,5,5′-hexachlorobiphenyl cotreatment on the disposition of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice. Toxicol. Lett. 80, 131-137.
17. Evans, M. G., and Sleight, S. D. (1989). Effects of simultaneous dietary exposure to 2,2′,4,4′,5,5′-hexabromobiphenyl and 3,3′,4,4′,5,5′-hexachlorobiphenyl on hepatic tumor promotion in rats. J. Am. Coll. Toxicol. 8(6), 1201-1206.
18. Fensterheim, R. J., (1993). Documenting temporal trends of polychlorinated biphenyls in the environment. Regul. Toxicol. Pharmacol. 18, 181-201.
19. Fex, G. A., Larsson, K., and Nilsson-Ehle, I. (1996). Serum concentrations of all-trans and 13-cis retinoic acid and retinol are closely correlated. Nutr. Biochem. 7, 162-165.
20. Flodström, S., and Ahlborg, U. G. (1989). Tumor promoting effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) - effects of exposure duration, administration schedule and type of diet. Chemosphere 19(1-6), 779-783.
21. Flodström, S., Busk, L., Kronevi, T., and Ahlborg, U. G. (1991). Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin A deficiency. Fundam. Appl. Toxicol. 16, 375-391.
22. Flodström, S., Wärngård, L., Ljungquist, S., and Ahlborg, U. G. (1988). Inhibition of metabolic cooperation in vitro and enhancement of enzyme altered foci incidence in rat liver by the pyrethroid insecticide fenvalerate. Arch. Toxicol. 61, 218-223.
23. Haag-Grönlund, M., Kato, Y., Fransson-Steen, R., Scheu, G., and Wärngård, L. (1997b). Promotion of enzyme altered foci in female rat livers by 2,3,3′,4,4′,5-hexachlorobiphenyl. Toxicol. Appl. Pharmacol. 147, 46-55.
24. Haag-Grönlund, M., Wärngård, L., Flodström, S., Scheu, G., Kronevi, T., Ahlborg, U. G., and Fransson-Steen, R. (1997a). Promotion of altered hepatic foci by 2,3′,4,4′,5,-pentachlorobiphenyl in Sprague-Dawley female rats. Fundam. Appl. Toxicol. 35, 120-130.
25. 3H) retinylacetate and on the vitamin A status in the rat. J. Nutr. 115, 759-771.
26. Hayes, M. A., Safe, S. H., Armstrong, D., and Cameron, R. G. (1985). Influence of cell proliferation on initiating activity of pure polychlorinated biphenyls and complex mixtures in resistant hepatocyte in vivo assays for carcinogenicity. J. Natl. Cancer Inst. 74(5), 1037-1041.
27. Hemming, H., Bager, Y., Flodström, S., Nordgren, I., Kronevi, T., Ahlborg, U. G., and Wärngård, L. (1995). Liver tumor promoting activity of 3,4,5,3′,4′-pentachlorobiphenyl and its interaction with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Sect. 292, 241-249.
28. Hemming, H., Flodström, S., Wärngård, L., Bergman, Å., Kronevi, T., Nordgren, I., and Ahlborg, U. G. (1993). Relative tumor promoting activity of three polychlorinated biphenyls in rat liver. Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Sect. 248, 163-174.
29. Hong, W. K., and Itri, L. M. (1994). Retinoids and human cancer. In Retinoids: Biology, Chemistry, and Medicine, 2nd ed. (M. B. Sporn, A. B., Roberts, and D. S. Goodman, Eds.), pp. 597-630. Raven Press, New York.
30. Jensen, R. K., and Sleight, S. D. (1986). Sequential study on the synergistic effects of 2,2′,4,4′,5,5′-hexabromobiphenyl and 3,3′,4,4′,5,5′-hexabromobiphenyl on hepatic tumor promotion. Carcinogenesis 7(10), 1771-1774.
31. Jetten, A. M. (1984). Modulation of cell growth by retinoids and their possible mechanisms of action. FASEB J. 43(1), 134-139.
32. 3H) phorbol ester binding in rat cerebellar granule cells by polychlorinated biphenyl mixtures and congeners: Structure-activity relationships. Toxicol. Appl. Pharmacol. 130, 140-148.
33. Korach, K. S., Sarver, P., Chae, K., McLachlan, J. A., and McKinney, J. D. (1988). Estrogen receptor-binding activity of polychlorinated hydroxybiphenyls: Conformationally restricted structural probes. Mol. Pharmacol. 33, 120-126.
34. Krowke, R., Chahoud, I., Baumann-Wilschke, I., and Neubert, D. (1989). Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin 2. Pharmacokinetics in rats using a loading-dose/maintenance-dose regime with high doses. Arch. Toxicol. 63, 356-360.
35. Liem, A. K. D., and Theelen, R. M. C. (1997). Dioxins: Chemical Analysis, Exposure and Risk Assessment. Thesis. National Institute of Public Health and the Environment, The Netherlands.
36. Lotan, R. (1995). Retinoids and apoptosis: Implications for cancer chemopre-vention and therapy. J. Natl. Cancer Inst. 87(22), 1655-1657.
37. Lubet, R. A., Nims, R. W., Mayer, R. T., Cameron, J. W., and Schechtman, L. M. (1985). Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenoxazones in hepatic S9s and hepatocyte homogenates: Effects of dicumarol. Mutat. Res. 142, 127-131.
38. Maronpot, R. R., Pitot, H. C., and Peraino, C. (1989). Use of rat liver altered focus models for testing chemicals that have completed two-year carcinogenicity studies. Toxicol. Pathol. 17(4), 651-662.
39. McFarland, V. A., and Clarke, J. U. (1989). Environmental occurrence, abundance, and potential toxicity of polychlorinated biphenyl congeners: Considerations for a congener-specific analysis. Environ. Health Perspect. 81, 225-239.
40. McKinney, J. D., and Waller, C. L. (1994). Polychlorinated biphenyls as hormonally active structural analogues. Environ. Health Perspect. 102(3), 290-297.
41. Mehta, R. (1995). The potential for the use of cell proliferation and oncogene expression as intermediate markers during liver carcinogenesis. Cancer Lett. 93, 85-102.
42. Moron, M., Sundström, G., and Wachtmeister, C. A. (1973). Polychlorinated biphenyls VI. 2,3,7,8-tetrachlorodibenzofuran, a critical byproduct in the synthesis of 2,2′,4,4′,5,5′-hexachlorobiphenyl by Ullman reaction. Acta Chem. Scand. 27, 3121-3122.
43. Morrissey, R. E., Harris, M. W., Diliberto, J. J., and Birnbaum, L. S. (1992). Limited PCB antagonism of TCDD-induced malformations in mice. Toxicol. Lett. 60, 19-25.
44. Ogiso, T., Tatematsu, M., Tamano, S., Hasegawa, R., and Ito, N. (1990). Correlation between medium-term liver bioassay system data and results of long-term testing in rats. Carcinogenesis 11(4), 561-566.
45. Pilot, H. C., Barsness, L., Goldsworthy, T., and Kitigawa, T. (1978). Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine. Nature 271, 456-457.
46. Safe, S. H. (1994). Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment Crit. Rev. Toxicol. 24(2), 87-149.
47. Sanders, G., Eisenreich, S. J., and Jones, K. C. (1994). The rise and fall of PCBs: Time-trend data from temperate industralised countries. Chemosphere 29(9-11), 2201-2208.
48. Sargent, L., Dragan, Y. P., Erickson, C., Laufer, C. J., and Pitot, H. C. (1991). Study of the separate and combined effects of the non-planar 2,5,2′,5′- and the planar 3,4,3′,4′-tetrachlorobiphenyl in liver and lymphocytes in vivo. Carcinogenesis 12(5), 793-800.
49. Seegal, R. F., Bush, B., and Shain, W. (1990). Lightly chlorinated ortho-substituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture. Toxicol. Appl. Pharmacol. 106, 136-144.
50. Shain, W., Bush, B., and Seegal, R. (1991). Neurotoxicity of polychlorinated biphenyls: Structure-activity relationship of individual congeners. Toxicol. Appl. Pharmacol. 111, 33-42.
51. Siegel, S., and Castellan, Jr., N. J. (1988). Nonparametric Statistics for the Behavioral Sciences (J. D. Anker, Ed.), p. 213. McGraw-Hill Book Co., New York.
52. Silberhorn, E. M., Glauert, H. P., and Robertson, L. W. (1990). Carcinogenicily of polyhalogenated biphenyls: PCBs and PBBs. Crit. Rev. Toxicol. 20, 440-496.
53. Smialowicz, R. J., DeVito, M. J., Riddle, M. M., Williams, W. C., and Birnbaum, L. S. (1997). Opposite effects of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antibody response to sheep erythrocytes in mice. Fundam. Appl. Toxicol. 37, 141-149.
54. Van Birgelen, A. P. J. M., Fase, K. M., Van der Kolk, J., Poiger, H., Brouwer, A., Seinen, W., and Van den Berg, M. (1996a). Synergistic effect of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in the rat. Environ. Health Perspect. 104(5), 550-557.
55. Van Birgelen, A. P., J. M., Ross, D. G., DeVito, M. J., and Birnbaum, L. S. (1996b). Interactive effects between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,2′,4,4′,5,5′-hexachlorobiphenyl in female B6C3F1 mice: Tissue distribution and tissue-specific enzyme induction. Fundam. Appl. Toxicol. 34, 118-131.
56. Van Birgelen, A. P. J. M., Van der Kolk, J., Fase, K. M., Bol, I., Poiger, H., Van den Berg, M., and Brower, A. (1994). Toxic potency of 2,3,3′,4,4′,5-hexachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat. Toxicol. Appl. Pharmacol. 126, 202-213.
57. Van Birgelen, A. P. J. M., Van der Kolk, J., Poiger, H., Van den Berg, M., and Brouwer, A. (1992). Interactive effects of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on thyroid hormone, vitamin A, and vitamin K metabolism in the rat. Chemosphere 25(7-10), 1239-1244.
58. Van Birgelen, A. P. J. M., Fase, K. M., Van der Kolk, J., Poiger, H., Brouwer, A., Seinen, W., and Van den Berg, M. (1996a). Synergistic effect of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on hepatic porphyrin levels in the rat. Environ. Health Perspect. 104(5), 550-557.
59. Van den Berg, M., De Jongh, J., Poiger, H., and Olson, J. R. (1994). The toxicokinetics and metabolism of polychlorinated dibenzo-p-dioxins (PC-DDs) and dibenzofurans (PCDFs) and their relevance for toxicity. Crit. Rev. Toxicol. 24(1), 1-74.
60. Van der Kolk, J., Van Birgelen, A. P. J. M., Poiger, H., and Schlatter, C. (1992). Interactions of 2,2′,4,4′,5,5′-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat. Chemosphere 25(12), 2023-2027.
61. Wærn, F., Flodström, S., Busk, L., Kronevi, T., Nordgren, I., and Ahlborg, U. G. (1991). Relative tumor promoting activity and toxicity of some polychlorinated dibenzo-p-dioxin- and dibenzofuran-congeners in female Sprague-Dawley rats. Pharmacol. Toxicol. 69, 450-458.
62. WHO/IPCS (1997). Derivation of toxic equivalency factors (TEFs) for dioxin-like compounds in humans and wildlife. In Organohalogen Compounds 34, (R. Hites, Ed.), School of Public and Environmental Affairs, Indiana University, Indianapolis, IN.
63. Wold, S., Albano, C., Dunn, III, W. J., Edlund, U., Esbensen, K., Geladi, P., Hellberg, S., Johansson, E., Lindberg, W., and Sjöström, M. (1984). Multivariate data analysis in chemistry. In Chemometrics: Mathematics and Statistics in Chemistry (B. R. Kowalski, Ed.), pp. 4-96. NATO ASI Series C138, D. Reidel, Dordrecht, The Netherlands.
64. Wyss, R., and Bucheli, F. (1988). Quantitative analysis of retinoids in biological fluids by high-performance liquid chromatography using column switching. I. Determination of isotretinoin and tretinoin and their 4-oxo metabolites in plasma. J. Chromatogr. 424, 303-314.