Detection of tumour DNA in serum of colorectal cancer patients

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 57, Issue 7, 1997, Pages 601-604

  De Kok, J B ^a   Van Solinge, W W ^a,b   Ruers, T J M ^a   Roelofs, R W H M ^a   Van Muijen, G N P ^a   Willems, J L ^a   Swinkels, D W ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b EEMLAND HOSPITAL   (Netherlands)

Author keywords

Circulating DNA; K ras; Mutation screening

Indexed keywords

ADVANCED CANCER; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA DETERMINATION; HUMAN; HUMAN TISSUE; ONCOGENE K RAS; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0030708629     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365519709055283     Document Type: Article

References (7)

1. Chen XQ, Stroun M, Magnenat JL, Nicod LP, Kurt AM, Lyautey J, et al. Microsatellite alterations in plasma DNA of small cell lung cancer patients. Nat Med 1996; 2: 1033-4.
2. Nawroz H, Koch W, Anker P, Stroun M, Sidransky D. Microsatellite alterations in serum DNA of head and neck cancer patients. Nat Med 1996; 2: 1035-7.
3. Mulcahy HE, Croke DT, Farthing MJG. Cancer and mutant DNA in blood plasma. Lancet 1996; 348: 628.
4. Hasegawa Y, Takeda S, Ichii S, Koizumi K, Maruyama M, Fujii A, et al. Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA). Oncogene 1995; 10: 1441-5.
5. Anker P, Lefort F, Vashioukhin V, Lyautey J, Lederrey C, Chen XQ, et al. K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer. Gastroenterology 1997; 112: 1114-20.
6. Oudejans JJ, Slebos RJC, Zoetmulder FAN, Mooi WJ, Rodenhuis S. Differential activation of ras genes by point mutation in human colon cancer with metastases to either lung or liver. Int J Cancer 1991; 49: 875-9.
7. Nagel S, Borisch B, Thein SL, Oestreicher M, Nöthiger F, Birrer S, et al. Somatic mutations detected by mini- and microsatellite DNA markers reveal clonal intratumor heterogeneity in gastrointestinal cancers. Cancer Res 1995; 55: 2866-70.