Nm23 expression in endometrial and cervical cancer: Inverse correlation with lymph node involvement and myometrial invasion

British Journal of Cancer

Volumn 74, Issue 7, 1996, Pages 1063-1068

  Marone, M ^a   Scambia, G ^a   Ferrandina, G ^a   Giannitelli, C ^a   Benedetti Panici, P ^a   Iacovella, S ^a   Leone, A ^b   Mancuso, S ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b Istituto Oncologico   (Italy)

Author keywords

Cervical cancer; Endometrial cancer; nm23

Indexed keywords

ARTICLE; BREAST CANCER; CANCER INVASION; CONTROLLED STUDY; CYTOPLASM; ENDOMETRIUM; ENDOMETRIUM CANCER; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MAJOR CLINICAL STUDY; MELANOMA; METASTASIS POTENTIAL; MYOMETRIUM; NORTHERN BLOTTING; OVARY CANCER; PRIORITY JOURNAL; PROGNOSIS; TREATMENT PLANNING; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CANCER;

EID: 0029744979     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.490     Document Type: Article

References (36)

1. AMBROS RA, VIGNA PA, FIGGE H, KALLAKURY BV, MASTRANGELO A, EASTMAN AY, MALFETANO J AND ROSS JS. (1994). Observations on tumor and metastatic suppressor gene status in endometrial carcinoma with particular emphasis on p53. Cancer, 73, 1686-1692.
2. AUSUBEL FM, BRENT R, KINGSTON RE, MOORE DD, SEIDMAN JG, SMITH JA AND STRUHL K. (1994). Current Protocols in Molecular Biology. John Wiley & Sons: Boston.
3. BENEDETTI-PANICI P, SCAMBIA G, BAIOCCHI G, GREGGI S, RAGUSA G, GALLO A, CONTE M, BATTAGLIA F, LAURELLI G, RABITTI C, CAPELLI A AND MANCUSO S (1991). Neoadjuvant chemotherapy and radical surgery in locally advanced cervical cancer. Cancer, 67, 372-379.
4. BEVILACQUA G, SOBEL ME, LIOTTA LA AND STEEG PS. (1989). Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph-node involvement and other histopathological indicators of high metastatic potential. Cancer Res., 49, 5185-5190.
5. CHOMCZYNSKI P AND SACCHI N. (1987). Single step method of RNA isolation by guanidium-thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
6. FLORENES VA, AAMDAL S, MYKLEBOST O, MAELANSMO GM, BRULAND DS AND FODSTAD D. (1992). Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression. Cancer Res., 52, 6088-6091.
7. GILLES AM, PRESECAN E, VONICA AND LASCU I. (1991). Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of hexameric enzyme. J. Biol. Chem., 266, 8784-8789.
8. HOWLETT AR, PETERSEN OW, STEEG PS AND BISSEL MJ. (1994). A novel function for the nm23-H1 gene: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. J. Natl Cancer Inst., 86(24), 1838-1844.
9. JIANG XP, LIU KD AND ZHOU XD. (1994). Cloning and sequencing of nm23-H3b, a new gene identified to nm23. Chinese Med. J., 74(11), 670-672.
10. KNECHT DA AND DIMOND RL. (1984). Visualization of antigenic proteins on Western blots. Anal. Biochem., 136, 180-184.
11. KONISHI N, NAKAOKA S, TSUZUKI T, MATSUMOTO K, KITAHORI Y, HIASA Y, URANO T AND SHIKU H. (1993). Expression of nm23-H1 and nm23-H2 proteins in prostate carcinoma. Jpn J. Cancer Res., 84, 1050-1054.
12. LEONE A, FLATOW U, KING CR, SANDEEN MA, MARGUILES IN, LIOTTA LA AND STEEG PS. (1991). Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell, 65, 25-39.
13. LEONE A, FLATOW U, VANHOUTTE K AND STEEG PS. (1993a). Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity. Oncogene, 8, 2325-2333.
14. LEONE A, SEEGER RC, HONG CM, ARBOLEDA MJ, BRODEUR GM, STRAM D, SLAMON DJ AND STEEG PS. (1993b). Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas. Oncogene, 8, 855-865.
15. LIOTTA LA AND STEEG PS. (1990). Clues to the function of nm23 and Awd proteins in development, signal transduction, and tumor metastasis provided by studies of Dictyostelium discoideum. J. Natl Cancer Inst., 82, 1170-1172.
16. LOMBARDI D, SACCHI A, D'AGOSTINO G AND TIBURSI G. (1995). The association of the nm23-M1 protein and beta-tubulin correlates with cell differentiation. Exp. Cell Res., 217, 267-271.
17. MACDONALD NJ, DE LA ROSA A, BENEDICT MA, FREIJE JM, KRUTSCH H AND STEEG PS. (1993). A serine phosphorilation of nm23 and not its nucleoside diphosphate kinase activity, correlates with suppression of tumor metastatic potential. J. Biol. Chem., 268, 25780-25789.
18. MANDAI M, KONISHI I, KOSHIYAMA M, MORI T, ARAO S, TASHIRO H, OKAMURA H, NOMURA H, HIAI H AND FUKUMOTO M. (1994). Expression and metastasis-related nm23-H1 and nm23-H2 genes in ovarian carcinomas: correlation with clinicopathology, EGFR, c-erbB-2 and c-erbB-3 genes, and sex steroid receptor expression. Cancer Res., 54, 1825-1830.
19. MYEROFF LL AND MARKOWITZ SD. (1993). Increased nm23-H1 and nm23-H2 messenger RNA expression and absence of mutations in colon carcinomas of low and high metastatic potential. J. Natl Cancer Inst., 85, 47-52.
20. NAKAYAMA T, OHTSURU A, NAKAO K, SHIMA M, NAKATA K, WATANABE K, ISHII N, KIMURA N AND NAGATAKI S. (1992). Expression in human hepatocellular carcinoma of nucleoside diphosphate kinase, a homologue of the nm23 gene product. J. Natl Cancer Inst., 84, 1349-1354.
21. NAKAYAMA H, YASUI W, YOKOZAKI H AND TOHARA E. (1993). Reduced expression of nm23 is associated with metastasis of human gastric carcinomas. Jpn. J. Cancer Res., 84, 184-190.
22. NICKERSON JA AND WELLS WW. (1984). The microtubule-associated nucleoside diphosphate kinase. J. Biol. Chem., 259, 1297-1304.
23. OHTSUKI K, IKEUCHI T AND YOKOYAMA M. (1986). Characterization of nucleoside diphosphate kinase-associated guanine nucleotide binding proteins from HeLa S3 cells. Biochim. Biophys. Acta, 882, 322-330.
24. OKABE-KADO J, KASUKABE T, HONMA Y, HAYASHI M, HENZEL WJ AND HOZUMI M. (1992). Identity of a differentiation inhibiting factor for mouse myeloid leukemia cells with nm23/ nucleotide diphosphate kinase. Biochem. Biophys. Res. Commun., 182, 987-994.
25. PETTERSON F. (1988). Annual Report on the Results of Treatment in Gynecologic Cancer. FIGO: Stockholm.
26. POSTEL EH AND FERRONE CA. (1994). Nucleoside diphosphate kinase enzyme activity of nm23-H2/PuF is not required for its DNA binding and in vitro transcriptional functions. J. Biol. Chem., 269, 8627-8630.
27. POSTEL EH, BERBERICH SJ, FLINT SJ AND FERRONE CA. (1993). Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. Science, 261, 478-480.
28. SAMBROOK J, FRITSCH EF AND MANIATIS T. (1989). Molecular Cloning: a Laboratory Manual. 2nd edition. Cold Spring Harbor Laboratory Press: New York.
29. SCAMBIA G, CATOZZI L, BENEDETTI-PANICI P, FERRANDINA G, BATTAGLIA F, GIOVANNINI G, DISTEFANO M, PELLIZZOLA D, PIFFANELLI A AND MANCUSO S. (1993). Expression of ras p21 oncoprotein in normal and neoplastic human endometrium. Gynecol. Oncol., 50, 339-346.
30. SCAMBIA G, FERRANDINA G, MARONE M, BENEDETTI-PANICI P, GIANNITELLI C, PIANTELLI M, LEONE A AND MANCUSO S. (1996). Nm23 in ovarian cancer: correlation with clinical outcome and other clinico-pathological and biochemical prognostic parameters. J. Clin. Oncol., 14, 334-342.
31. STAHL JA, LEONE A, ROSENGARD AM, PORTER L, KING CR AND STEEG PS. (1991). Identification of a second human nm23 gene, nm23-H2. Cancer Res., 51, 445-449.
32. STEEG PS, BEVILACQUA G, KOPPER L, THORGEIRSSON UP, TALMADGE JE, LIOTTA LA AND SOBEL ME. (1988). Evidence for a novel gene associated with a low tumor metastatic potential. J. Natl Cancer Inst., 80, 200-204.
33. TOKUNAGA Y, URANO T, FURUKAWA K, KONDO H, KANEMATSU T AND SHIKU H. (1993). Reduced expression of nm23-H1, but not of nm23-H2, is concordant with the frequency of lymph-node metastasis of human breast cancer. Int. J. Cancer, 55, 66-71.
34. VIEL A, DALL'AGNESE L, CANZONIERI V, SOPRACORDEVOLE F, CAPOZZI E, CARBONE A, VISENTIN MC AND BOIOCCHI M. (1995). Suppressive role of the metastasis-related nm23-H1 gene in human ovarian carcinomas: association of high messenger RNA expression with lack of lymph node metastasis. Cancer Res., 55, 2645-2650.
35. WALTON G AND GILL G. (1975). Nucleotide regulation of an eukaryotic protein synthesis initiation complex. Biochim. Biophys. Acta, 300, 231-245.
36. WORLD HEALTH ORGANIZATION. (1979). WHO Handbook for Reporting Results of Cancer Treatment, no. 48. WHO: pp. 16-21. Geneva.