Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas

International Journal of Cancer

Volumn 79, Issue 4, 1998, Pages 324-333

  Kim, Kwonseop ^a   Cai, Jinguo ^a   Shuja, Sania ^a,b   Kuo, Tom ^a   Murnane, Mary Jo ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CYSTEINE PROTEINASE; RAS PROTEIN;

ARTICLE; CANCER CLASSIFICATION; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; ONCOGENE RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BLOTTING, WESTERN; CARCINOMA; CATHEPSIN B; CATHEPSINS; COLORECTAL NEOPLASMS; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; GENES, RAS; HUMANS; MUTATION; RAS PROTEINS;

EID: 0031874052     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980821)79:4<324::AID-IJC4>3.0.CO;2-X     Document Type: Article

References (32)

1. BALLIN, M., GOMEZ, D.E., SINHA, C.C. and THORGEIRSSON, U.P., Ras oncogene mediated induction of a 92 kDa metalloproteinase. Biochem. Biophys. Res. Comm., 154, 832-835 (1988).
2. BARRETT, A.J. and KIRSCHKE, H., Cathepsin B, cathepsin H, cathepsin L. Methods Enzymol., 80, 535-561 (1981).
3. BELL, S.M., SCOTT, N., CROSS, D., SAGAR, P., LEWIS, F. A., BLAIR, G.E., TAYLOR, G.R., DIXON, M.F. and QUIRKE, P., Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer. Gastroenterology, 104, 57-64 (1993).
4. BOKOCH, G.M. and DER, C.J., Emerging concepts in the ras superfamily of GTP-binding proteins. FASEB J., 7, 750-759 (1993).
5. BOS, J.L., The ras gene family and human carcinogenesis. Mutation Res., 195, 255-271 (1988).
6. CAPON, D.J., SEEBERG, P.H., MCGRATH, J.P., HAYFLICK, J.S., EDMAN, U., LEVINSON, A.D. and GOEDDEL, D.V., Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. Nature (Lond.), 304, 507-512 (1983).
7. CHAMBERS, A.F. and TUCK, A.B., Ras-responsive genes and tumor metastasis. Crit. Rev. Oncogenesis, 4, 95-114 (1993).
8. ENGEL, G., POPOWICZ, P., MARSHALL, H., NORLING, G., SVENSSON, C., AUER, G., AKUSJARVI, G., and LINDER, S., Elevated stromelysin-1 and reduced collagenase-IV expression in invasive rat embryo fibroblasts expressing E1A deletion mutants + T24-H-ras. Int. J. Cancer, 51, 761-766 (1992).
9. FINKELSTEIN, S.D., SAYEGH, R., CHRISTENSEN, S. and SWALSKY, P.A., Genotypic classification of colorectal adenocarcinoma. Cancer, 71, 3827-3838 (1993).
10. GUO, X., ZHANG, Y.P., MITCHELL, D.A. and CHAMBERS, A.F., Identification of a ras-activated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity correlates with the metastatic potential of the cell. Mol. cell. Biol. 15, 476-487 (1995).
11. ras oncoprotein in a transformation-suppressed cell line. Oncogene, 6, 1211-1217 (1991).
12. IACOBUZIO-DONAHUE, C.A., SHUJA, S., CAI, J., PENG, P. and MURNANE, M.J., Elevations in cathepsin B protein content and enzyme activity occur independently of glycosylation during colorectal tumor progression. J. biol. Chem., 272, 29190-29199 (1997).
13. ISHIDOH, K., SUZUKI, K., KATUNUMA, N. and KOMINAMI, E., Gene structures of rat cathepsins H and L. Biomed. biochim. Acta, 50, 541-547 (1991).
14. JOSEPH, L., LAPID, S. and SUKHATME, V., The major ras induced protein in NIH3T3 cells is cathepsin L. Nucl. Acids Res., 15, 3186 (1987).
15. KAHN, S.M., JIANG, W., CULBERTSON, T.A., WEINSTEIN, B., WILLIAMS, G.M., TOMITA, N., and RONAJ, Z., Rapid and sensitive nonradioactive detection of mutant K-ras genes via "enriched" PCR amplification. Oncogene, 6, 1079-1083 (1991).
16. KHOSRAVI-FAR, R., COX, A.D., KATO, K. and DER, C.J., Protein prenylation: key to ras function and cancer intervention? Cell Growth Differentiation, 3, 461-469 (1992).
17. KIM, K., KUO, T., CAI, J., SHUJA, S. and MURNANE, M.J., N-ras protein: frequent quantitative and qualitative changes occur in human colorectal carcinomas. Int. J. Cancer, 71, 767-775 (1997).
18. LOWRY, O.H., ROSEBROUGH, N.J., FARR, A.L. and RANDALL, R.J., Protein measurement with the Folin phenol reagent. J. biol. Chem., 193, 265-275 (1951).
19. MACGREGOR, R.R., HAMILTON, J.W., SHOFSTALL, R.E. and COHN, D.V., Isolation and characterization of porcine parathyroid cathepsin B. J. biol. Chem., 254, 4423-4427 (1979).
20. MASON, R.W., GAL, S. and GOTTESMAN, M.M., The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L. Biochem. J., 248, 449-454 (1987).
21. MURNANE, M.J., SHUJA, S., DEL RE, E., CAI, J., IACOBUZIO-DONAHUE, C. and KLEPEIS, V., Characterizing human colorectal carcinomas by proteolytic profile. In Vivo, 11, 209-216 (1997).
22. NICHOLS, E.A. and RUDDLE, F.H., A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gel. J Histochem. Cytochem., 21, 1066-1081 (1973).
23. QIAN, F., FRANKFATER, A., CHAN, S.J. and STEINER, D.F., The structure of the mouse cathepsin B gene and its putative promoter. DNA Cell Biol., 10, 159-168 (1991).
24. REDDY, M.A., LANGER, S., COLMAN, M.S. and OSTROWSKI, M., An enhancer element responsive to ras and fms signaling pathways is composed of two distinct nuclear factor binding sites. Mol. Endocrinol., 6, 1051-1060 (1992).
25. SATOH, T., ENDO, M., NAKAFUKU, M., AKIYAMA, T., YAMAMOTO, T. and KAZIRO, Y., Accumulation of p21ras-GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc. nat. Acad. Sci. (Wash.), 87, 7926-7929 (1990).
26. SCHROY, P.C., BROWN-SHIMER, S., KIM, K., JOHNSON, K.A., MURNANE, M.J., YANG, S., O'BRIEN, M.J., CARNEY, W.P. and KUPCHIK, H.Z., Detection of p21 ras mutations in colorectal adenomas and carcinomas by enzyme-linked immunosorbent assay. Cancer, 76, 201-209 (1995).
27. SHEAHAN, K., SHUJA, S. and MURNANE, M.J., Cysteine protease activities and tumor development in human colorectal carcinoma. Cancer Res., 49, 3809-3814 (1989).
28. SHUJA, S., SHEAHAN, K. and MURNANE, M.J., Cysteine endopeptidase activity levels in normal human tissues, colorectal adenomas and carcinomas. Int. J. Cancer, 49, 341-346 (1991).
29. SILBERMAN, S., JANULIS, M. and SCHULTZ, R.M., Characterization of downstream Ras signals that induce alternative protease-dependent invasive phenotypes. J. biol. Chem., 272, 5927-5935 (1997).
30. TROEN, B.R., CHAUHAN, S., RAY, D. and GOTTESMAN, M.M., Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters. Cell Growth Differentiation, 2, 23-31 (1991).
31. TURNBULL, R.B., KYLE, K., WATSON, F.R. and SPRATT, J., Cancer of the colon. Ann. Surg., 166, 420-427 (1967).
32. ZHANG, X., SETTLEMAN, J., KYRIAKIS, J.M., ELLEDGE, S.J., MARSHALL, M.S., BRUDER, J.T., RAPP, U.R. and AVRUCH, J., Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature (Lond.), 364, 308-313 (1993).