UBP1, a novel hnRNP-like protein that functions at multiple steps of higher plant nuclear pre-mRNA maturation

EMBO Journal

Volumn 19, Issue 7, 2000, Pages 1638-1649

  Lambermon, Mark H L ^a   Simpson, Gordon G ^b   Wieczorek Kirk, Dominika A ^a   Hemmings Mieszczak, Maja ^a   Klahre, Ulrich ^a   Filipowicz, Witold ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b JOHN INNES CENTRE   (United Kingdom)

Author keywords

3' UTR; hnRNP proteins; mRNA splicing; Plant RNA processing; RNA binding protein

Indexed keywords

ADENINE; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; UBP1; UNCLASSIFIED DRUG; URACIL;

3' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; INTRON; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTOPLAST; REPORTER GENE; RNA PROCESSING; RNA SPLICING;

EMBRYOPHYTA; NICOTIANA PLUMBAGINIFOLIA;

EID: 0034599523     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.7.1638     Document Type: Article

References (42)

1. Baynton, C.E., Potthoff, S.J., McCullough, A.J. and Schuler, M.A. (1996) U-rich tracts enhance 3′ splice site recognition in plant nuclei. Plant J., 10, 703-711.
2. Bentley, D. (1999) Coupling RNA polymerase II transcription with pre-mRNA processing. Curr. Opin. Cell Biol., 11, 347-351.
3. Beven, A.F., Simpson, G.G., Brown, J.W. and Shaw, P.J. (1995) The organization of spliceosomal components in the nuclei of higher plants. J. Cell Sci., 108, 509-518.
4. Brown, C.E. and Sachs, A.B. (1998) Poly(A) tail length control in S.cerevisiae occurs by message-specific deadenylation. Mol. Cell. Biol., 18, 6548-6559.
5. Brown, J.W.S. and Simpson, C.G. (1998) Splice site selection in plant pre-mRNA splicing. Annu. Rev. Plant Physiol. Plant Mol. Biol., 49, 77-95.
6. Burge, C.B., Tuschl, T. and Sharp, P.A. (1999) Splicing of precursors to mRNAs by the spliceosomes. In Gesteland, R.F., Cech, T.R. and Atkins, J.F. (eds), The RNA World. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 525-560.
7. Callis, J., Fromm, M. and Walbot, V. (1987) Introns increase gene expression in cultured maize cells. Genes Dev., 1, 1183-1200.
8. Connelly, S. and Filipowicz, W. (1993) Activity of chimeric U small nuclear RNA (snRNA)/mRNA genes in transfected protoplasts of N.plumbaginifolia: U snRNA 3′-end formation and transcription initiation can occur independently in plants. Mol. Cell. Biol., 13, 6403-6415.
9. Cramer, P., Caceres, J.F., Cazalla, D., Kadener, S., Muro, A.F., Baralle, F.E. and Kornblihtt, A.R. (1999) Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. Mol. Cell, 4, 251-258.
10. Crispino, J.D., Blencowe, B.J. and Sharp, P.A. (1994) Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science, 265, 1866-1869.
11. Domon, C., Lorkovic, Z.J., Valcarcel, J. and Filipowicz, W. (1998) Multiple forms of the U2 small nuclear ribonucleoprotein auxiliary factor U2AF subunits expressed in higher plants. J. Biol. Chem., 273, 34603-34610.
12. Dreyfuss, G., Matunis, M.J., Pinol-Roma, S. and Burd, C.G. (1993) hnRNP proteins and the biogenesis of mRNA. Annu. Rev. Biochem., 62, 289-321.
13. Ge, H., Si, Y. and Wolffe, A.P. (1998) A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol. Cell, 2, 751-759.
14. Genschik, P., Hall, J. and Filipowicz, W. (1997) Cloning and characterization of the Arabidopsis cyclic phosphodiesterase which hydrolyzes ADP-ribose 1″,2″-cyclic phosphate and nucleoside 2′,3′-cyclic phosphates. J. Biol. Chem., 272, 13211-13219.
15. Gniadkowski, M., Hemmings-Mieszczak, M., Klahre, U., Liu, H.X. and Filipowicz, W. (1996) Characterization of intronic uridine-rich sequence elements acting as possible targets for nuclear proteins during pre-mRNA splicing in N.plumbaginifolia. Nucleic Acids Res., 24, 619-627.
16. Goodall, G.J. and Filipowicz, W. (1989) The AU-rich sequences present in the introns of plant nuclear pre-mRNAs are required for splicing. Cell, 58, 473-483.
17. Goodall, G.J. and Filipowicz, W. (1991) Different effects of intron nucleotide composition and secondary structure on pre-mRNA splicing in monocot and dicot plants. EMBO J., 10, 2635-2644.
18. Gueydan, C., Droogmans, L., Chalon, P., Huez, G., Caput, D. and Kruys, V. (1999) Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor α mRNA. J. Biol. Chem., 274, 2322-2326.
19. Huang, Y., Wimler, K.M. and Carmichael, G.G. (1999) Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing. EMBO J., 18, 1642-1652.
20. Ko, C.H., Brendel, V., Taylor, R.D. and Walbot, V. (1998) U-richness is a defining feature of plant introns and may function as an intron recognition signal in maize. Plant Mol. Biol., 36, 573-583.
21. Körner, C.G. and Wahle, E. (1997) Poly(A) tail shortening by a mammalian poly(A)-specific 3′-exoribonuclease. J. Biol. Chem., 272, 10448-10456.
22. Krämer, A. (1996) The structure and function of proteins involved in mammalian pre-mRNA splicing. Annu. Rev. Biochem., 65, 367-409.
23. Krecic, A. and Swanson, M.S. (1999) HnRNP complexes: composition, structure and function. Curr. Opin. Cell Biol., 11, 363-371.
24. Liu, X. and Mertz, J.E. (1995) HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression. Genes Dev., 9, 1766-1780.
25. Lopato, S., Kalyna, M., Dorner, S., Kobayashi, R., Krainer, A.R. and Barta, A. (1999) atSRp30, one of two SF2/ASF-like proteins from Arabidopsis thaliana, regulates splicing of specific plant genes. Genes Dev., 13, 987-1001.
26. Lou, H., McCullough, A.J. and Schuler, M.A. (1993) 3′ Splice site selection in dicot plant nuclei is position dependent. Mol. Cell. Biol., 13, 4485-4493.
27. Luehrsen, K.R. and Walbot, V. (1994a) Addition of A- and U-rich sequence increases the splicing efficiency of a deleted form of a maize intron. Plant Mol. Biol., 24, 449-463.
28. Luehrsen, K.R. and Walbot, V. (1994b) Intron creation and polyadenylation in maize are directed by AU-rich RNA. Genes Dev., 8, 1117-1130.
29. MacMillan, A.M., McCaw, P.S., Crispino, J.D. and Sharp, P.A. (1997) SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract. Proc. Natl Acad. Sci. USA, 94, 133-136.
30. Matsumoto, K., Wassarman, K.M. and Wolffe, A.P. (1998) Nuclear history of a pre-mRNA determines the translational activity of cytoplasmic mRNA. EMBO J., 17, 2107-2121.
31. Mayeda, A. and Krainer, A.R. (1992) Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell, 68, 365-375.
32. McCullough, A.J., Lou, H. and Schuler, M.A. (1993) Factors affecting authentic 5′ splice site selection in plant nuclei. Mol. Cell. Biol., 13, 1323-1331.
33. Michael, W.M., Choi, M. and Dreyfuss, G. (1995) A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway. Cell, 83, 415-122.
34. Mieszczak, M., Klahre, U., Levy, J.H., Goodall, G.J. and Filipowicz, W. (1992) Multiple plant RNA binding proteins identified by PCR: expression of cDNAs encoding RNA binding proteins targeted to chloroplasts in N.plumbaginifolia. Mol. Gen. Genet., 234, 390-400.
35. Nakielny, S. and Dreyfuss, G. (1997) Nuclear export of proteins and RNAs. Curr. Opin. Cell Biol., 9, 420-429.
36. Rothnie, H.M. (1996) Plant mRNA 3′-end formation. Plant Mol. Biol., 32, 43-61.
37. Rothnie, H.M., Reid, J. and Hohn, T. (1994) The contribution of AAUAAA and the upstream element UUUGUA to the efficiency of mRNA 3′-end formation in plants. EMBO J., 13, 2200-2210.
38. Simpson, G.G. and Filipowicz, W. (1996) Splicing of precursors to mRNA in higher plants: mechanism, regulation and sub-nuclear organisation of the spliceosomal machinery. Plant Mol. Biol., 32, 1-41.
39. Tarn, W.Y. and Steitz, J.A. (1994) SR proteins can compensate for the loss of U1 snRNP functions in vitro. Genes Dev., 8, 2704-2717.
40. Vaucheret, H., Beclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.B., Mourrain, P., Palauqui, J.C. and Vernhettes, S. (1998) Transgene-induced gene silencing in plants. Plant J., 16, 651-659.
41. Visa, N., Alzhanova-Ericsson, A.T., Sun, X., Kiseleva, E., Bjorkroth, B., Wurtz, T. and Daneholt, B. (1996) A pre-mRNA-binding protein accompanies the RNA from the gene through the nuclear pores and into polysomes. Cell, 84, 253-264.
42. Wahle, E. and Ruegsegger, U. (1999) 3′-End processing of pre-mRNA in eukaryotes. FEMS Microbiol. Rev., 23, 277-295.