Genetic control of pathogenic mechanisms in autoimmune demyelinating disease

Journal of Neuroimmunology

Volumn 110, Issue 1-2, 2000, Pages 168-176

  Sabelko Downes, Kimberly A ^a   Gimenez, Maryann T ^a   Suvannavejh, Graig C ^b   Miller, Stephen D ^b   Russell, John H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Autoimmunity; EAE MS; Fas (CD95); Genetic heterogeneity; In vivo animal models; Inflammation

Indexed keywords

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; DEMYELINATING DISEASE; DISEASE COURSE; GENE CONTROL; IMMUNOHISTOCHEMISTRY; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ANIMAL; ANTIGENS, CD95; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENCEPHALOMYELITIS, EXPERIMENTAL AUTOIMMUNE; GENE EXPRESSION; GENETIC HETEROGENEITY; GUINEA PIGS; IMMUNIZATION; MICE; MICE, CONGENIC; MICE, MUTANT STRAINS; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; PHENOTYPE; SPINAL CORD; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0034597123     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(00)00350-7     Document Type: Article

References (30)

1. Bruck W., Schmied M., Suchanek G., Bruck Y., Breitschopf H., Poser S., Piddlesden S., Lassmann H. Oligodendrocytes in the early course of multiple sclerosis. Ann. Neurol. 35:1994;65-73.
2. Butterfield R.J., Sudweeks J.D., Blankenhorn E.P., Korngold R., Marini J.C., Todd J.A., Roper R.J., Teuscher C. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J. Immunol. 161:1998;1860-1867.
3. Butterfield R.J., Blankenhorn E.P., Roper R.J., Zachary J.F., Doerge R.W., Sudweeks J., Rose J., Teuscher C. Genetic analysis of disease subtypes and sexual dimorphisms in mouse experimental allergic encephalomyelitis (EAE): relapsing/remitting and monophasic remitting/nonrelapsing EAE are immunogenetically distinct. J. Immunol. 162:1999;3096-3102.
4. Butterfield R.J., Doerge R.W., Blankenhorn E.P., Zachary J.F., Roper R., Teuscher C. Multiple Sexually Dimorphic Quantitative Trait Loci (QTL) Control Histopathology in EAE. 1999;FASEB Autoimmunity, Saxton River, VT.
5. Dal Canto M.C., Melvold R.W., Kim B.S., Miller S.D. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison. Microsc. Res. Tech. 32:1995;215-229.
6. Ebers G.C., Kukay K., Bulman D.E., Sadovnick A.D., Rice G., Anderson C., Armstrong H., Cousin K., Bell R.B., Hader W., Paty D.W., Hashimoto S., Oger J., Duquette P., Warren S., Gray T., Nath A., Auty A., Metz L., Francis G., Paulseth J.E., Murray T.J., Pryse-Phillips W., Risch N., et al. A full genome search in multiple sclerosis (see comments). Nat Genet. 13:1996;472-476.
7. Elliott E.A., McFarland H.I., Nye S.H., Cofiell R., Wilson T.M., Wilkins J.A., Squinto S.P., Matis L.A., Mueller J.P. Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. J. Clin. Invest. 98:1996;1602-1612.
8. Fritz R.B., McFarlin D.E. Encephalitogenic epitopes of myelin basic protein. Chem. Immunol. 46:1989;101-125.
9. Fritz R.B., Chou C.H., McFarlin D.E. Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J×PL/J)F1 mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant. J. Immunol. 130:1983;191-194.
10. Haines J.L., Ter-Minassian M., Bazyk A., Gusella J.F., Kim D.J., Terwedow H., Pericak-Vance M.A., Rimmler J.B., Haynes C.S., Roses A.D., Lee A., Shaner B., Menold M., Seboun E., Fitoussi R.P., Gartioux C., Reyes C., Ribierre F., Gyapay G., Weissenbach J., Hauser S.L., Goodkin D.E., Lincoln R., Usuku K., Oksenberg J.R., et al. A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group (see comments). Nat Genet. 13:1996;469-471.
11. Kira J., Kanai T., Nishimura Y., Yamasaki K., Matsushita S., Kawano Y., Hasuo K., Tobimatsu S., Kobayashi T. Western versus Asian types of multiple sclerosis: immunogenetically and clinically distinct disorders. Ann. Neurol. 40:1996;569-574.
12. Kuokkanen S., Sundvall M., Terwilliger J.D., Tienari P.J., Wikstrom J., Holmdahl R., Pettersson U., Peltonen L. A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2 (see comments). Nat. Genet. 13:1996;477-480.
13. Lublin F.D., Reingold S.C. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology. 46:1996;907-911.
14. Lucchinetti C.F., Bruck W., Rodriguez M., Lassmann H. Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis. Brain Pathol. 6:1996;259-274.
15. Malipiero U., Frei K., Spanaus K.S., Agresti C., Lassmann H., Hahne M., Tschopp J., Eugster H.P., Fontana A. Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice. Eur. J. Immunol. 27:1997;3151-3160.
16. Mokhtarian F., McFarlin D.E., Raine C.S. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature. 309:1984;356-358.
17. Okuda Y., Bernard C.C., Fujimura H., Yanagihara T., Sakoda S. Fas has a crucial role in the progression of experimental autoimmune encephalomyelitis. Mol. Immunol. 35:1998;317-326.
18. Olerup O., Hillert J., Fredrikson S., Olsson T., Kam-Hansen S., Moller E., Carlsson B., Wallin J. Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities. Proc Natl Acad Sci USA. 86:1989;7113-7117.
19. Ozawa K., Suchanek G., Breitschopf H., Bruck W., Budka H., Jellinger K., Lassmann H. Patterns of oligodendroglia pathology in multiple sclerosis. Brain. 117:1994;1311-1322.
20. Panitch H.S., McFarlin D.E. Experimental allergic encephalomyelitis: enhancement of cell-mediated transfer by concanavalin A. J. Immunol. 119:1977;1134-1137.
21. Raine C.S. Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis. Lab. Invest. 50:1984;608-635.
22. Sabelko K.A., Kelly K.A., Nahm M.H., Cross A.H., Russell J.H. Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyelitis, but are not essential for immune privilege in the central nervous system. J. Immunol. 159:1997;3096-3099.
23. Sabelko-Downes K.A., Cross A.H., Russell J.H. Dual role for Fas ligand in the initiation of and recovery from experimental allergic encephalomyelitis. J. Exp. Med. 189:1999;1195-1205.
24. Sawcer S., Jones H.B., Feakes R., Gray J., Smaldon N., Chataway J., Robertson N., Clayton D., Goodfellow P.N., Compston A. A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22 (see comments). Nat. Genet. 13:1996;464-468.
25. Sundvall M., Jirholt J., Yang H.T., Jansson L., Engstrom A., Pettersson U., Holmdahl R. Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat. Genet. 10:1995;313-317.
26. Suvannavejh G.C., Dal Canto M.C., Matis L.A., Miller S.D. Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis. J. Clin. Invest. 105:2000;223-231.
27. Swanborg R.H., Swierkosz J.E., Saieg R.G. Studies on the species-variability of experimental allergic encephalomyelitis in guinea pigs and rats. J. Immunol. 112:1974;594-600.
28. Waldner H., Sobel R.A., Howard E., Kuchroo V.K. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. J. Immunol. 159:1997;3100-3103.
29. Zamvil S.S., Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8:1990;579-621.
30. Zamvil S.S., Nelson P.A., Mitchell D.J., Knobler R.L., Fritz R.B., Steinman L. Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition. J. Exp. Med. 162:1985;2107-2124.