G protein-coupled, extracellular Ca2+ (Ca2+o)-sensing receptor enables Ca2+o to function as a versatile extracellular first messenger

Cell Biochemistry and Biophysics

Volumn 33, Issue 1, 2000, Pages 63-95

  Brown, Edward M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Calcium homeostasis; Calcium sensing receptor; Cytosolic calcium; Extracellular calcium; G protein coupled receptor; Kidney cells; Parathyroid cells

Indexed keywords

CALCIUM; CALCIUM SENSING RECEPTOR; CELL SURFACE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL; BIOLOGICAL MODEL; CALCIUM SIGNALING; CHEMICAL STRUCTURE; CHEMISTRY; HOMEOSTASIS; HUMAN; METABOLISM; PARATHYROID GLAND; PHYSIOLOGY; PROTEIN SECONDARY STRUCTURE; REVIEW;

ANIMALS; CALCIUM; CALCIUM SIGNALING; GTP-BINDING PROTEINS; HOMEOSTASIS; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PARATHYROID GLANDS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CALCIUM-SENSING; RECEPTORS, CELL SURFACE;

EID: 0034578111     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1385/CBB:33:1:63     Document Type: Article

References (165)

1. 2+ and other ions as extracellular (first) messengers. Physiol. Rev. 71, 371-411.
2. Pietrobon, D., Di Virgilio, F., and Pozzan, T. (1990) Structural and functional aspects of calcium homeostasis in eukaryotic cells. Eur. J. Biochem. 120, 599-622.
3. Stewart, A. F. and Broadus, A. E. (1987) Mineral Metabolism, in Endocrinology and Metabolism, 2nd ed., Felig, P., Baxter, J. D., Broadus, A. E., and Frohman, L. A. eds), McGraw-Hill, New York, NY, 1317-1453.
4. 2--sensing. Endocrinologist 4, 419-426.
5. 3 by calcium in the parathyroidectomized, parathyroid hormone-replete rat. J. Bone. Miner. Res. 4, 929-935.
6. Quamme, G. A. (1982) Effect of hypercalcemia on renal tubular handling of calcium and magnesium. Can. J. Physiol. Pharmacol. 60, 1275-1280.
7. Raisz, L. G. and Niemann, I. (1969) Effect of phosphate, calcium, and magnesium on bone resorption and bone formation in tissue culture. Endocrinology 85, 446-452.
8. Zaidi, M., Datta, H. K., Patchell, A., Moonga, B., and MacIntyre, I. (1989) "Calcium-activated" intracellular calcium elevation: a novel mechanism of osteoclast regulation. Biochem. Biophys. Res. Commun. 183, 1461-1465.
9. Malgaroli, A., Meldolesi, J., Zambone-Zallone, A., and Teti, A. (1989) Control of cytosolic free calcium in rat and chicken osteoclasts. The role of extracellular calcium and calcitonin. J. Biol. Chem. 264, 14342-14349.
10. Silver, I. A., Murrils, R. J., and Etherington, D. J. (1988) Microlectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp. Cell. Res. 175, 266-276.
11. Quarles, D. L., Hartle II, J. E., Siddhanti, S. R., Guo, R., and Hinson, T. K. (1997) A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor. J. Bone Miner. Res. 12, 393-402.
12. Sugimoto, T., Kanatani, M., Kano, J., Kaji, H., Tsukamato, T., Yamaguchi, T., Fukase, M., and Chihara, K. (1993) Effects of high calcium concentration on the functions and interactions of osteoblastic cells and monocytes and on the formation of osteoclast-like cells. J. Bone Miner. Res. 8, 1445-1452.
13. Kanatani, M., Sugimoto, T., Fukase, M., and Fujita, T. (1991) Effect of extracellular calcium on the proliferation of osteoblastic MC3T3-E1 cells: its direct and indirect effects via monocytes. Biochem. Biophys. Res. Commun. 181, 1425-1430.
14. Godwin, S. L. and Soltoff, S. P. (1997) Extracellular calcium and platelet-derived growth factor promote receptor-mediated chemotaxis in osteoblasts through different signaling pathways. J. Biol. Chem. 272, 11307-11312.
15. Honda, Y., Fitzsimmons, R. J., Baylink, D. J., and Mohan, S. (1995) Effects of extracellular calcium on insulin-like growth factor II in human bone cells. J. Bone Miner. Res. 10, 1660-1665.
16. Siegel, A. M. and Daly, J. W. (1985) Receptor (norepinephrine), P-site (2′,5′-dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cAMP generating systems in human platelets. J. Cyclic Nucleotide Protein Phosphorylation Res. 10, 229-246.
17. 2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets. Biochem, Pharmacol. 38, 1841-1847.
18. Hennings, H., Michael, D., Cheng, C., Steinert, P., Holbrook, K., and Yuspa, S. H. (1980) Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19, 245-254.
19. Bikle, D., Ratnam, A., Mauro, T., Harris, J., and Pillai, S. (1996) Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J. Clin. Invest. 97, 1085-1093.
20. McGrath, C. M. and Soule, H. D. (1984) Calcium regulation of normal human mammary epithelial cells in culture. In Vitro Dev. Dev. Biol. 20, 652-662.
21. Southgate, J., Hutton, K. A., Thomas, D. F., and Trejdosiewicz, L. K. (1994) Normal human urothelial cells in vitro: proliferation and induction of stratification. Lab. Invest. 71, 583-594.
22. Buset, M., Lipkin, M., Winawer, S., Swaroop, S., and Friedman, E. (1986) Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium. Cancer Res. 46, 5426-5430.
23. Black, B. and Smith, J. (1989) Regulation of goblet cell differentiation by calcium in embryonic chick intestine. FASEB J. 3, 2653-2659.
24. Rizzoli, R., and Bonjour, J.-P. (1989) High extracellular calcium increases the production of parathyroid hormone-like activity by cultured leydig cells associated with humoral hypercal-cemia. J. Bone Miner. Res. 4, 839-844.
25. 2+-sensing receptor from bovine parathyroid. Nature 366, 575-580.
26. Chattopadhyay, N., Mithal, A., and Brown, E. M. (1996) The calcium-sensing receptor: a window into the physiology and pathophysiology of mineral ion metabolism. Endocrine Rev. 17, 289-307.
27. 2+ receptor-dependent regulation of cellular functions. News Physiol. Sci. 10, 1-5.
28. Garrett, J. E., Capuano, I. V., Hammerland, L. G., Hung, B. C. P., Brown, E. M., Hebert, S. C., Nemeth, E. F., and Fuller, F. (1995) Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J. Biol. Chem. 270, 12919-12925.
29. Diaz, R., Hurwitz, S., Chattopadhyay, N., Pines, M., Yang, Y., Kifor, O., Einat, M., Butters, R., Hebert, S., and Brown, E. (1997) Cloning, expression and tissue localization of the calcium-sensing receptor in the chicken (Gallus domesticus). Am. J. Physiol. 273, R1008-R1016.
30. Riccardi, D., Park, J., Lee, W. -S., Gamba, G., Brown, E. M., and Hebert, S. C. (1995) Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc. Natl. Acad. Sci. USA 92, 131-135.
31. 2+-sensing receptor cDNA from human kidney. Biochem. Biophys. Res. Commun. 214, 524-529.
32. Butters Jr, R. R., Chattopadhyay, N., Nielsen, P., et al. (1997) Cloning and characterization of a calcium-sensing receptor from the hypercalcemic New Zealand white rabbit reveals unaltered responsiveness to extracellular calcium. J. Bone Miner. Res. 12, 568-579.
33. Garrett, J. E., Tamir, H., Kifor, O., Simin, R. T., Rogers, K. V., Mithal, A., Gagel, R. F., and Brown, E. M. (1995) Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene. Endocrinology 136, 5202-5211.
34. Freichel, M., Zinc-Lorenz, A., Hollishi, A., Hafner, M., Flockerzi, V., and Raue, F. (1996) Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion. Endocrinology 137, 3842-3848.
35. 2+-sensing receptor. J. Biol. Chem. 271, 5972-5976.
36. Hinson, T. K., Damodaran, T. V., Chen, J., Zhang, X., Qumsiyeh, M. B., Seldin, M. F., and Quarles, L. D. (1997) Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor. Genomics 45, 279-289.
37. Brown, E. M., Bai, M., Pollak, M. (1997) Familial benign hypocalciuric hypercalcemia and other syndromes of altered responsiveness to extracellular calcium, in Metabolic Bone Diseases, 3rd ed., (Krane, S. M., and Avioli, L. V., eds.), Academic Press, San Diego, CA, pp. 479-499.
38. Fliegel, L., Ohnishi, M., Carpenter, M. R., Khanna, V. K., Reithmeier, R. A. F., and MacLennan, D. H. (1987) Amino acid sequence of rabbit fast-twitch skeletal muscle calsequestrin from its cDNA and peptide sequencing. Proc. Natl. Acad. Sci. USA 84, 1167-1171.
39. Brown, E. (1983) Four parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue. J. Clin. Endocrinol. Metab. 56, 572-581.
40. o-sensing receptor J. Biol. Chem. 271, 19537-19545.
41. 2- receptor is essential for its expression at the cell surface. Endocrinology 138, 1916-1922.
42. Chattopadhyay, N. and Brown, E. M. (1997) Calcium-sensing receptor: roles in and beyond systemic calcium homeostasis. Biol. Chem. 378, 759-768.
43. Kolakowski, L. F. (1994) GCRDb: a G-protein-coupled receptor database. Receptors Channels 2, 1-7.
44. Nakanishi, S. (1994) Metabotropic glutamate receptors: synaptic transmission, modulation and plasticity. Neuron 13, 1031-1037.
45. Matsunami, H. and Buck, L. B. (1997) A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell 90, 775-784.
46. Ryba, N. J. P. and Trindell, R. (1997) A new multigene family of putative pheromone receptors. Neuron 19, 371-379.
47. Kaupmann, K., Huggel, K., Heid, J., et al (1997) Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptor. Nature 386, 239-246.
48. Oh, B.-H., Pandit, J., Kang, C-H., Nikaido, K., Gokcen, S., Ames, G. F. L., and Kim, S.-H. (1993) Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand. J. Biol. Chem. 268, 11348-11355.
49. O'Hara, P., Sheppard, P., Thogersen, H., Venezia, D., Haldeman, B., McGrane, V., Houamed, K., Thomsen, C., Gilbert, T., and Mulvihill, E. (1993) The ligand binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron 11, 41-52.
50. Tam, R. and Saier Jr, M. H. (1993) Structural functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Microbiol. Rev. 57, 320-346.
51. Sharff, A. J., Rodseth, L. E., Spurlino, J. C., and Quiocho, F. A. (1992) Crystallographic evidence for a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis. Biochemistry 31, 10657-10663.
52. 2+ in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells. J. Bone Miner. Res. 12, 715-725.
53. Moriarty, T., Sealfon, S., Carty, D., Roberts, J., and Iyengar, R. (1989) Coupling of exogenous receptors to phospholipase C in Xenopus laevis oocytes through pertussis toxin-sensitive and-insensitive pathways. Cross-talk between heterotrimeric G-proteins. J. Biol. Chem. 264, 13, 524-13,530.
54. 2+-sensing receptor (CaR) activate nonselective cation channels in HEK293 cells stably transfected with the human CaR. Biochem. Biophys. Res. Commun. 226, 572-579.
55. 2+ and channel blockers. Am. J. Physiol. 269, E864-E877.
56. Fajtova, V., Quinn, S., and Brown, E. (1991) Cytosolic calcium responses of single rMTC 44-2 cells to stimulation with external calcium and potassium. Am. J. Physiol. 261, E151-158.
57. 2+-sensing receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line. Mol. Endocrinol. 10, 555-565.
58. Chen, C., Barnett, J., Congo, D., and Brown, E. (1989) Divalent cations suppress 3′, 5′-adenosine monophosphate accumulation by stimulating a pertussis toxin-sensitive guanine nucleotide-binding protein in cultured bovine parathyroid cells. Endocrinology 124, 233-239.
59. Chang, W., Pratt, S., Chen, T.-S., E, N., Huang, Z., and Shoback, D. (1998) Coupling of calcium receptors to inositol phosphate and cAMP generation in mammalian cells and Xenopus oocytes and immunodetection of receptor protein by region-specific antipeptide antisera. J. Bone Miner. Res. 13, 570-580.
60. Takaichi, K. and Kurokawa, K. (1988) Inhibitory guanosine triphosphate-binding protein-mediated regulation of vasopressin action in isolated single medullary tubules of mouse kidney. J. Clin. Invest. 82, 1437-1444.
61. Firsov, D., Aarab, L., Mandon, B., Siaume-Perez, S., Rouffignac, S. D., and Chabardes, D. (1995) Arachidonic acid inhibits hormone-stimulated cAMP accumulation in the medullary thick ascending limb of the rat kidney by a mechanism sensitive to pertussis toxin. Pfleugers Arch. 429, 636-646.
62. 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J. Clin. Endocrinol. Metab. 81, 1598-1606.
63. Gogusev, J., Duchambon, P., Hory, B., Giovannini, M., Goureau, Y., Sarfati, E., and Drueke, T. (1997) Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int. 51, 328-336.
64. 2+ receptor mRNA and protein increase in the rat parathyroid gland with age. J. Endocrinol 153, 437-444.
65. Ho, C., Conner, D. A., Pollak, M., Ladd, D. J., Kifor, O., Warren, H., Brown, E. M., Seidman, C. E., and Seidman, J. G. (1995) A mouse model for familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nature Genet. 11, 389-394.
66. Marx, S. J., Attie, M. F., Levine, M. A., Spiegel, A. M., Downs Jr, R. W., and Lasker, R. D. (1981) The hypocalciuric or benign variant of familial hypercalcemia: clinical and biochemical features in fifteen kindreds. Medicine (Baltimore) 60, 397-412.
67. Law Jr, W. M. and Heath III, H. (1985) Familial benign hypercalcemia (hypocalciuric hypercalcemia). Clinical and pathogenetic studies in 21 families. Ann. Int. Med. 105, 511-519.
68. Khosla, S., Ebeling, P. R., Firek, A. F., Burritt, M. M., Kao, P. C., and Heath III, H. (1993) Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 76, 715-720.
69. Estep, H., Mistry, Z., and Burke, P. 1981 Familial idiopathic hypocalcemia, in Proceedings and Abstracts of the 63rd Annual Meeting of the Endocrine Society, Cincinnati, OH, 275 (Abstract).
70. 2+-sensing receptor. J. Clin. Endocrinol. Metab. 82, 2710-2715.
71. 2+-sensing receptor gene mutation. Nat. Genet. 8, 303-307.
72. Kobayashi, M., Tanaka, H., Tsuzuki, K., Tsuyuki, M., Igaki, H., Ichinose, Y., Aya, K., Nishioka, N., and Seino, Y. (1997) Two novel missense mutations in calcium-sensing receptor gene associated with neonatal severe hyperparathyroidism. J. Clin. Endocrinol. Metab. 82, 2716-2719.
73. Heath, D. A. (1994) Familial hypocalciuric hypercalcemia, In The Parathyroids, Bilezikian, J. P., Marcus, R., and Levine, M. A. eds.), Raven Press, New York, NY, pp. 699-710.
74. Cooper, L., Wertheimer, J., Levey, R., Brown, E., LeBoff, M., Wilkinson, R., and Anast, C. (1986) Severe primary hyperparathyroidism in a neonate with two hypercalcemic parents: management with parathyroidectomy and heterotopic autotransplantation. Pediatrics 78, 263-268.
75. Marx, S., Lasker, R., Brown, E., Fitzpatrick, L., Sweezey, N., Goldbloom, R., Gillis, D., and Cole, D. (1986) Secretory dysfunction in parathyroid cells from a neonate with severe primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 62, 445-449.
76. Kremer, R., Bolivar, I., Goltzman, D., and Hendy, G. N. (1989) Influence of calcium and 1,25-dihydroxycholecalciferol on proliferation and proto-oncogene expression in primary cultures of bovine parathyroid cells. Endocrinology 125, 935-941.
77. Wada, M., Furuya, Y., Sakiyama, J.-i., Kobayashi, N., Miyata, S., Ishii, H., and Hagano, N. (1997) The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. J. Clin. Invest. 100, 2977-2983.
78. 2+ in rat C-cells. J. Biol. Chem. 261, 7669-7674.
79. Eskert, R., Scherubl, H., Petzelt, C., Friedhelm, R., and Ziegler, R. (1989) Rhythmic oscillations of cytosolic calcium in rat C-cells. Mol. Cell. Endocrinol. 64, 267-270.
80. 2+ channels. Arch. Biochem. Biophys. 265, 128-135.
81. Pocotte, S., Ehrenstein, G., and Fitzpatrick, L. (1995) Role of calcium channels in parathyroid hormone secretion. Bone 16, S365-S372.
82. 2+ in bovine parathyroid cells by external divalent cations. J. Biol. Chem. 202, 5188-5196.
83. 2+-induced calcitonin secretion. Am. J. Physiol. 264, E354-360.
84. 2+ receptor-stimulated hormone release from sheep thyroid parafollicular cells. J. Physiol. 502, 31-44.
85. Tamir, H., Liu, K. P., Aldersberg, M., Hsuiung, S. C., and Gershon, M. D. (1996) Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor. J. Biol. Chem. 271, 6441-6450.
86. 2+-sensing receptor and PTH/PTHrP receptor in rat Kidney. Am. J. Physiol. 271, F951-F956.
87. 2+-sensing receptor mRNAs along the rat nephron. Am. J. Physiol. 272, F751-F758.
88. 2+/(polyvalent cation)-sensing receptor protein in rat kidney. Am. J. Physiol. 274, F611-F622.
89. Sands, J. M., Naruse, M., Baum, M., Jo, I., Hebert, S. C., Brown, E. M., and Harris, W. H. (1997) Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J. Clin. Invest. 99, 1399-1405.
90. Quamme, G. A. and Dirks, J. H. (1980) Intraluminal and contraluminal magnesium on magnesium and calcium transfer in the rat nephron. Am. J. Physiol. 238, F187-F198.
91. Brown, E. M. and Hebert, S. C. (1997) Calcium-receptor regulated parathyroid and renal function. Bone 20, 303-309.
92. 2+-sensing receptor in divalent mineral ion homeostasis. J. Exp. Biol. 200, 295-302.
93. De Rouffignac, C. and Quamme, G. A. (1994) Renal magnesium handling and its hormonal control. Physiol. Rev. 74, 305-322.
94. + channels in the TAL. Am. J. Physiol. 271, C103-C111.
95. Attie, M. F., Gill Jr, J., Stock, J. L., Spiegel, A. M., Downs Jr, R. W., Levine, M. A., and Marx, S. J. (1983) Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism. J. Clin. Invest. 72, 667-676.
96. Davies, M., Adams, P. H., Lumb, G. A., Berry, J. L., and Loveridge, N. (1984) Familial hypocalciuric hypercalcemia: evidence for continued enhanced renal tubular reabsorption of calcium following total parathyroidectomy. Acta Endocrinol. 106, 499-504.
97. Gill, J. J. and Bartter, F. (1961) On the impairment of renal concentrating ability in prolonged hypercalcemia and hypercalciuria in man. J. Clin. Invest. 40, 716-722.
98. Suki, W. M., Eknoyan, G., Rector Jr, F. C., and Seldin, D. W. (1969) The renal diluting and concentrating mechanism in hypercalcemia. Nephron 6, 50-61.
99. 2+-sensing receptor. Regulatory Peptide Letter VII, 43-47.
100. Marx, S. J., Attie, M. F., Stock, J. L., Spiegel, A. M., and Levine, M. A. (1981) Maximal urine-concentrating ability: familial hypocalciuric hypercalcemia versus typical primary hyper-parathyroidism. J. Clin. Endocrinol. Metab. 52, 736-740.
101. Pearce, S. H. S., Williamson, C., Kifor, O., et al (1996) A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. N. Engl. J. Med. 335, 1115-1122.
102. Rogers, K. V., Dunn, C. E., Brown, E. M., and Hebert, S. C. (1997) Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization. Brain Res. 744, 47-56.
103. Simpson, J. B. and Routenberg, A. (1975) Subfornical organ lesions reduce intravenous angiotensin-induced drinking. Brain Res. 88, 154-161.
104. Tordoff, M. G. (1994) Voluntary intake of calcium and other minerals by rats. Am. J. Physiol. 167, R470-R475.
105. House, M. G., Kohlmeier, L., Chattopadhyay, N., Kifor, O., LeBoff, M. S., Glowacki, J., and Brown, E. M. (1997) Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells. J. Bone Miner. Res. 12, 1959-1970.
106. 3 involves extracellular, but not intracellular, calcium. J. Cell. Physiol. 142, 434-439.
107. o)-sensing receptor in the clonal osteoblast-like cell lines, UMR-106 and SAOS-2. Biochem. Biophys. Res. Commun. 243, 753-757.
108. Quarles, L. D. (1997) Cation-sensing receptors in bone: a novel paradigm for regulating bone remodeling? J. Bone Miner. Res. 12, 1971-1974.
109. 2+-sensing receptor in rat intestine. Am. J. Physiol. 274, G122-G130.
110. 2+-sensing receptor in intestinal epithelium. Am. J. Physiol. 273, C1168-C1175.
111. Kallay, E., Kifor, O., Chattopadhyay, N., Brown, E. M., Bischoff, M. G., Peterlik, M., and Cross, H. S. (1997) Calcium dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells: a role for a luminal extracellular calcium-sensing receptor. Biochem. Biophys. Res. Commun. 232, 80-83.
112. Whitfield, J. (1995) Calcium as differentiator and killer-colon cells, in Calcium in Cell Cycles and Cancer (Whitfield, J. F., ed.), CRC Press, New York, NY, pp. 153-177.
113. Rodda, C. P., Caple, I. W., and Martin, T. J. (1992) Role of PTHrP in fetal and neonatal physiology, in Parathyroid Hormone Related Protein: Normal Physiology and its Role in Cancer. (Halloran, B. P., and Nissenson, R. A., ed.), CRC Press, Boca Raton, FL, pp. 169-196.
114. Hellman, P., P, R., Juhlin, C., Akerstrom, G., Rastad, J., and Gylfe, E. (1992) Parathyroid-like regulation of parathyroid-hormone-related protein release and cytoplasmic calcium in cytotrophoblast cells of human placenta. Arch. Biochem. Biophys. 293, 174-180.
115. 2+ in cytotrophoblast cells of human placenta. J. Biol. Chem. 265, 8275-8280.
116. 2+ and nucleotides. J. Endocrinol. 149, 135-144.
117. 2+ sensing receptor in cytotrophoblasts from human term placenta. J. Endocrinol. 156, 425-430.
118. 2+-binding receptor with potential intracellular signaling properties. Eur. J. Biochem. 239, 132-137.
119. Saito, A., Pietromonaco, S., Loo, A. K., and Farquhar, M. G. (1994) Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc. Natl. Acad. Sci. USA 91, 9725-9729.
120. Ray, J. M., Squires, P. E., Curtis, S. B., Meloche, M. R., and Buchan, A. M. J. (1997) Expression of the calcium-sensing receptor on human antral gastrin cells. J. Clin. Invest. 99, 2328-2333.
121. Friedman, P. and Gesek, F. (1995) Cellular calcium transport in renal epithelia: measurement, mechanisms, and regulation. Physiol. Rev. 75, 429-471.
122. 3. Nature 339, 478-480.
123. Prentice, A., Jarjou, L. M. A., Cole, T. J., Stirling, D. M., Dibba, B., and Fairweather-Tait, S. (1995) Calcium requirements of lactating Gambian mothers, effects of a calcium supplement on breast-milk calcium concentration, maternal bone mineral content and urinary calcium excretion. Am. J. Clin. Nutr. 62, 58-67.
124. Valtin, H. (1983) Renal Function: Mechanisms Preserving Fluid and Electrolyte Balance in Health. Little, Brown and Co., Boston, MA.
125. Cheng, I., Klingensmith, M. K., Chattopadhyay, N., Butters, R. R., Soybel, D. I., and Brown, E. M. (1998) Identification and localization of the extracellular calcium-sensing receptor in human breast. J. Clin. Endocrinol Metab. 83, 703-707.
126. Heinemann, U., Lux, H. D., and Gutnick, M. J. (1977) Extracellular free calcium and potassium during paroxysmal activity in cerebral cortex of the rat. Expt. Brain Res. 27, 237-243.
127. Arens, J., Stabel, J., and Heinemann, U. (1992) Pharmacological properties of excitatory amino acid induced changes in extracellular calcium concentration in rat hippocampal slices. Can. J. Physiol. Pharmacol. 70, S194-S205.
128. Lucke, A., Kohling, R., Straub, H., Moskopp, D., Wassman, H., and Speckmann, E.-J. (1995) Changes of extracellular calcium concentration induced by application of excitatory amino acids in the human neocortex in vitro. Brain Res. 671, 222-226.
129. Nicholson, C., Ten Bruggencate, G., Steinberg, R., and Strokle, H. (1977) Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective microelectrode. Proc. Natl. Acad. Sci. USA 74, 1287-1290.
130. 2+ in the synaptic cleft. Biophys. J. 72, 1-14.
131. Jahr, C. E. and Stevens, C. F. (1993) Calcium permeability of the N-methyl D-aspartate receptor channel in hippocampal neurons in culture. Proc. Natl. Acad. Sci. USA 90, 11573-11577.
132. Bliss, T. V. P. and Collingridge, G. L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
133. Brown E. M., Vassilev, P. V., and Hebert, S. C. (1995) Calcium ions as extracellular messengers. Cell 83, 679-682.
134. Ruat, M., Molliver, M. E., Snowman, A. M., and Snyder, S. H. (1995) Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals. Proc. Natl. Acad. Sci. USA 92, 3161-3165.
135. Chattopadhyay, N., Légrádi, G., Bai, M., Kifor, O., Ye, C., Vassilev, P. M., Brown, E. M., and Lechan, R. M. (1997) Calcium-sensing receptor in the rat hippocampus: a developmental study. Dev. Brain Res. 100, 13-21.
136. Bers, D. M. (1983) Early transient depletion of extracellular Ca during individual cardiac muscle contractions. Am. J. Physiol. 244, H462-H468.
137. Almers, W., Fink, R., and Palade, P. T. (1981) Calcium depletion in frog muscle tubules: the decline of calcium current under maintained depolarization. J. Physiol. (Lond.) 312, 177-207.
138. Perez-Armandariz, E. M., Atwater, I., and Bennett, M. V. L. (1995) Mechanisms for fast intercellular communication within single islet of Langerhans, in Pacemaker Activity and Intercellular Communication (Huizinga, J. D., ed.), CRC Press, Boca Raton, FL, pp. 305-321.
139. Anderson, R. G. W. (1993) Plasmalemmal carcolae and GPI-anchored membrane proteins. Curr Opin. Cell Biol. 5, 647-652.
140. Lisanti, M. P., Tang, Z., Scherer, P. E., Kubler, E., Koleske, A. J., and Sargiacomo, M. (1995) Caveolae, transmembrane signalling and cellular transformation. Mol. Memb. Biol. 12, 121-124.
141. Kifor, O., Diaz, R., Butters, R., and Brown, E. M. (1998) The calcium-sensing recepter is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J. Biol. Chem. 273, 21708-21713.
142. Mailland, M., Waelchli, R., Ruat, M., Boddeke, H. G. W. M., and Seuwen, K. (1997) Stimulation of cell proliferation by calcium and a calcimimetic compound. Endocrinology 138, 3601-36-5.
143. McNeill, S. E., Hobson, S. A., Nipper, K. D., and Rodland, K. D. (1998) Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium. J. Biol. Chem. 273, 1114-1120.
144. 2+-sensing receptor agonists of non-selective cation channels in rat hippocampal neurons. Biochem. Biophys. Res. Commun. 224, 271-280.
145. o-sensing receptor gene. Brain Res. Bull. 44, 75-84.
146. + channels is blunted in CaR gene-deficient mouse neurons. Neuroreport 8, 1411-1416.
147. Quinn, S. J., Ye, C. P., Diaz, R., Kifor, O., Bai, M., Vassilev, P., and Brown, E. M. (1997) The calcium-sensing receptor: a target for polyamines. Am. J. Physiol. 273, C1315-C1323.
148. 2+-permeable channels through calcium-sensing receptors. J. Neurosci. Res. 47, 547-554.
149. Chattopadhyay, N., Ye, C., Kifor, O., Yamaguchi, T., Vassilev, P. M., Nishimura, R., and Brown, E. M. (1998) Extracellular calcium-sensing receptor in rat oligodendrocytes: expressing and potential role in regulation of proliferation and an outward kt channel. Glia 24, 449-458..
150. Delamere, N. A. and Paterson, C. A. (1981) Hypocalcaemic cataract in Mechanisms of Cataract Formation in the Human Lens (Duncan, G., ed.), Academic Press, New York, pp. 219-236.
151. Duncan, G. and Bushell, A. R. (1975) Ion analyses of human cataractous lenses. Exp. Eye Res. 20, 223-230.
152. Chattopadhyay, N., Ye, C., Singh, D. P., Kifor, O., Vassilev, P. M., Sinohara, T., Chylack Jr, L. T., and Brown, E. M. (1997) Expression of extracellular calcium-sensing receptor by human lens epithelial cells. Biochem. Biophys. Res. Commun. 233, 801-805.
153. 2+ in dispersed bovine parathyroid cells. Endocrinology 136, 2238-2243.
154. Bornefalk, E., Ljunghall, S., Lindh, E., Bengsten, O., Johansson, A., and Ljunggren, O. (1997) Regulation of interleukin-6 secretion from mononuclear blood cells by extracellular calcium. J. Bone Miner. Res. 12, 228-233.
155. 2+ regulates the response to human recombinant erythropoietin (rHuEPO) in hemodialysis patients. Int. J. Artific. Organs 13, 747-750.
156. Brown, A., Zhong, M., Finch, J., Ritter, C., McCracken, R., Morrissey, J., and Slatopolsky, E. (1996) Rat calcium-sensing receptor is regulated by vitamin D but not by calcium. Am. J. Physiol. 270, F454-F460.
157. 2+ concentration. Biochemistry 34, 9277-9281.
158. Galkin, B. M., Feig, S. A., Patchefsky, A. S., Rue, J. W., Gamblin Jr, W. J., Gomez, D. G., and Marchant, L. M. (1977) Ultrastructure and microanalysis of "benign" and "malignant" breast calcifications. Radiology 124, 245-249.
159. Percival, R. C., Yates, A. J., and Gray, R. E. (1985) Mechanism of malignant hypercalcemia in carcinoma of the breast. Br. Med. J. Clin. Res. 291, 776-779.
160. Moscat, J., Fleming, T. P., Molloy, C. J., Lopez-Barahona, M., and Aaronson, S. A. (1989) The calcium signal for Balb/MK keratinocyte terminal differentiation induces sustained alterations in phosphoinositide metabolism without detectable protein kinase-C activation. J. Biol. Chem. 264, 11228-11235.
161. Behar, J., Hitchings, M., and Smyth, R. D. (1977) Calcium stimulation of gastrin and gastric acid secretion: effect of small doses of calcium carbonate. Gut 18, 442-448.
162. Lundgren, S., Hjalm, G., Hellman, P., Ek, B., Juhlin, C., Rastad, J., Klareskog, L., Akerstrom, G., and Rask, L. (1994) A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily. Exp. Cell Res. 212, 344-350.
163. o)-chemotaxis and proliferation of mc3T3-E1 cells. J. Bone Mineral Res. 13, 1530-1538.
164. 2+ sensing. J. Clin. Invest. 96, 1582-1590.
165. Silverberg, S. J., Bone III, H. G., Marriott, T. B., Locker, F. G., Thys-Jacobs, S., Dziem, G., Kaatz, S., Sanguinetti, E. L., and Bilezikian, J. P. (1997) Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism. N. Engl. J. Med. 337, 1506-1510.