Interactions between N-acetylcysteine and ascorbic acid in modulating mutagenesis and carcinogenesis

International Journal of Cancer

Volumn 88, Issue 5, 2000, Pages 702-707

  D'Agostini, Francesco ^a   Balansky, Roumen M ^b   Camoirano, Anna ^a   De Flora, Silvio ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b National Oncology Center Bulgaria   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ASCORBIC ACID; CHROMIUM; THIOL; URETHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CARCINOGENICITY; CONTROLLED STUDY; FEMALE; GLUTATHIONE METABOLISM; LUNG CARCINOMA; MOUSE; MUTAGENICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SPONTANEOUS MUTATION;

ACETYLCYSTEINE; ANIMALS; ASCORBIC ACID; CARCINOGENICITY TESTS; CELL TRANSFORMATION, NEOPLASTIC; CHROMIUM; DRUG STABILITY; FEMALE; LUNG NEOPLASMS; MICE; MUTAGENESIS; URETHANE;

EID: 0034569928     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20001201)88:5<702::AID-IJC4>3.0.CO;2-3     Document Type: Article

References (57)

1. Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine
2. An improved bacterial test system for the detection and classification of mutagens and carcinogens
3. The antioxidant action of N-acetylcysteine
4. Effects of cigarette smoke and disulfiram on tumorigenicity and clastogenicity of ethyl carbamate in mice
5. Chemoprevention by N-acetylcysteine of urethane-induced lung tumors in mice, as related to the time-course monitoring of micronuclei in peripheral blood erythrocytes
6. The production of activated oxygen species by an interaction of methemoglobin with ascorbate
7. Intracellular glutathione levels regulate fos/jun induction and activation of glutathione S-transferase gene expression
8. N-Acetylcysteine inhibits endothelial cell invasion and angiogenesis while protecting from apoptosis
9. Ascorbic acid and cancer: A review
10. Dual role of thiols in N-methyl-N-nitro-N-nitrosoguanidine genotoxicity
11. Genotoxicity of volatile and secondary reactive oxygen species generated by photosensitization
12. Protection of nuclear enzymes by aminothiols
13. Mechanisms of inhibitors of mutagenesis and carcinogenesis
14. Inhibition of urethan-induced lung tumors in mice by dietary N-acetylcysteine
15. Mechanisms of anticarcinogenesis: The example of N-acetylcysteine
16. Inhibition of the 'spontaneous' mutagenicity in Salmonella typhimurium TA102 and TA104
17. Role of glutathione and N-acetylcysteine as inhibitors of mutagenesis and carcinogenesis
18. Mutagenicity of active oxygen species in bacteria and its enzymatic or chemical inhibition
19. Estimates of the chromium(VI) reducing capacity in human body compartments as a mechanism for attenuating its potential toxicity and carcinogenicity
20. Chemopreventive properties and mechanisms of N-acetylcysteine. The experimental background
21. Antigenotoxic and anticarcinogenic effects of thiols. In vitro inhibition of the mutagenicity of drug nitrosation products and protection of rat liver ADP-ribosyl transferase activity
22. Detoxifying activities in alveolar macrophages of rats treated with acetylcysteine, diethyl maleate and/or Aroclor
23. Mechanisms of chromium metabolism and genotoxicity
24. Oxygen radicals in lung pathology
25. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm
26. Ascorbate is an outstanding antioxidant in human blood pasma
27. 2/M DNA damage checkpoint during oxidative stress
28. 6-ethenoadenosine
29. Treatment of acute chromate poisoning
30. Supplementation of N-acetylcysteine inhibits NFκB activation and protects against alloxan-induced diabetes in CD-1 mice
31. Ascorbic acid enhances forskolin-induced cyclic AMP production and pro-ANF mRNA expression of hypothalamic neurons in culture
32. 32p postlabeling
33. Clinical development plans for cancer chemopreventive agents: N-acetyl-L-cysteine
34. Experimental bases for ascorbic acid therapy of poisoning by hexavalent chromium compounds
35. Micronutrients and their influence on mutagenicity and malignant transformation
36. Methyldonors deficiency due to chemically induced glutathione depletion
37. A new Salmonella tester strain (TA102) with A · T base pairs at the site of mutation detects oxidative mutagens
38. 1 prolongation by the chemopreventive agent N-acetylcysteine
39. Ascorbate stimulation of PAT cells causes an increase in transcription rates and a decrease in degradation of procollagen mRNA
40. Revised methods for the Salmonella mutagenicity test
41. Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase
42. Metabolism and function of glutathione
43. On the antioxidant effects of ascorbic acid and glutathione
44. Glutathione, ascorbate, and cellular protection
45. Ascorbate-nitrite reaction: Possible means of blocking the formation of carcinogenic compounds
46. Vinyl carbamate epoxide, a major strong electrophilic, mutagenic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate (urethane)
47. Identification of plasmid (pKM101) coded proteins involved in mutagenesis and UV resistance
48. Tissue-mediated regeneration of ascorbic acid: Is the process enzymatic?
49. Causes
50. Genetic toxicology of ascorbic acid
51. Lung tumors in mice: Application to carcinogenesis bioassay
52. Ascorbate modulation of chondrocyte gene expression is independent of its role in collagen secretion
53. Observation of the functions of peroxidase systems and the chemistry of the adrenal cortex
54. The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective
55. Comparison of superoxide with other reducing agents in the biological production of hydoxyl radicals
56. The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice