-
1
-
-
0002548405
-
5-Fluoropyrimidines
-
Chabner, B. A.; Longo, D. L., eds. Philadelphia: Lippincott-Raven
-
Grem, J. L. 5-Fluoropyrimidines. In: Chabner, B. A.; Longo, D. L., eds. Cancer chemotherapy and biolherapy. Philadelphia: Lippincott-Raven; 1996:149-212.
-
(1996)
Cancer Chemotherapy and Biolherapy
, pp. 149-212
-
-
Grem, J.L.1
-
2
-
-
0024997423
-
Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murinc (L1210) and human (W1L2) systems in vitro and in L1210 in vivo
-
Jackman, A. L.; Taylor, G. A.; O'Connor, B. M.; Bishop, J. A.; Moran, R. G.; Calvert, A. H. Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murinc (L1210) and human (W1L2) systems in vitro and in L1210 in vivo. Cancer Res. 50:5212-5218; 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 5212-5218
-
-
Jackman, A.L.1
Taylor, G.A.2
O'Connor, B.M.3
Bishop, J.A.4
Moran, R.G.5
Calvert, A.H.6
-
3
-
-
0025997350
-
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
-
Jackman, A. L.; Taylor, G. A.; Gibson, W.; Kimbell, R.; Brown, M.; Calvert, A. H.; Judson, I. R.; Hughes, L. R. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: A new agent for clinical study. Cancer Res. 51:5579-5586; 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 5579-5586
-
-
Jackman, A.L.1
Taylor, G.A.2
Gibson, W.3
Kimbell, R.4
Brown, M.5
Calvert, A.H.6
Judson, I.R.7
Hughes, L.R.8
-
4
-
-
0031052281
-
Folate-based thymidylate synthase inhibitors in cancer chemotherapy
-
Takemura, Y.; Jackman, A. L. Folate-based thymidylate synthase inhibitors in cancer chemotherapy. Anticancer Drugs 8:3-16; 1997.
-
(1997)
Anticancer Drugs
, vol.8
, pp. 3-16
-
-
Takemura, Y.1
Jackman, A.L.2
-
5
-
-
9244240774
-
Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors
-
Clarke, S. J.; Hanwell, J.; de Boer, M.; Planting, A.; Verweij, J.; Walker, M.; Smith, R.; Jackman, A. L.; Hughes, L. R.; Harrap, K. R.; Kennealey, G. T.; Judson, I. R. Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors. J. Clin. Oncol. 14:1495-1503;1996.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 1495-1503
-
-
Clarke, S.J.1
Hanwell, J.2
De Boer, M.3
Planting, A.4
Verweij, J.5
Walker, M.6
Smith, R.7
Jackman, A.L.8
Hughes, L.R.9
Harrap, K.R.10
Kennealey, G.T.11
Judson, I.R.12
-
6
-
-
0031978715
-
14C]-raltitrexed in cancer patients
-
14C]-raltitrexed in cancer patients. Cancer Chemother. Pharmacol. 42:71-76; 1998.
-
(1998)
Cancer Chemother. Pharmacol.
, vol.42
, pp. 71-76
-
-
Beale, P.1
Judson, I.2
Hanwell, J.3
Berry, C.4
Aherne, W.5
Hickish, T.6
Martin, P.7
Walker, M.8
-
7
-
-
9344267746
-
A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor
-
Smith, I.; Jones, A.; Spielmann, M.; Namer, M.; Green, M. D.; Bonneterre, J.; Wander, H. E.; Halschek, T.; Wilking, N.; Zalcberg, J.; Spiers, J.; Seymour, L. A phase II study in advanced breast cancer: ZD1694 ('Tomudex') a novel direct and specific thymidylate synthase inhibitor. Br. J. Cancer 74:479-481;1996.
-
(1996)
Br. J. Cancer
, vol.74
, pp. 479-481
-
-
Smith, I.1
Jones, A.2
Spielmann, M.3
Namer, M.4
Green, M.D.5
Bonneterre, J.6
Wander, H.E.7
Halschek, T.8
Wilking, N.9
Zalcberg, J.10
Spiers, J.11
Seymour, L.12
-
8
-
-
9044245305
-
ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer
-
Tomudex Colorectal Study Group.
-
Zalcberg, J. R.; Cunningham, D.; Van Cutsem, E.; Francois, E.; Schornagel, J.; Adenis, A.; Green, M.; Iveson, A.; Azab, M.; Seymour, I. ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Tomudex Colorectal Study Group. J. Clin. Oncol. 14:716-721; 1996.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 716-721
-
-
Zalcberg, J.R.1
Cunningham, D.2
Van Cutsem, E.3
Francois, E.4
Schornagel, J.5
Adenis, A.6
Green, M.7
Iveson, A.8
Azab, M.9
Seymour, I.10
-
9
-
-
0031888857
-
Mature results from three large controlled studies with raltitrexed ('Tomudex')
-
Cunningham, D. Mature results from three large controlled studies with raltitrexed ('Tomudex'). Br. J. Cancer 77(Suppl. 2):15-21; 1998.
-
(1998)
Br. J. Cancer
, vol.77
, Issue.2 SUPPL.
, pp. 15-21
-
-
Cunningham, D.1
-
10
-
-
0031935917
-
Measuring quality of life: Impact of chemotherapy for advanced colorectal cancer. Experience from two recent large phase III trials
-
Anderson, H.; Palmer, M. K. Measuring quality of life: Impact of chemotherapy for advanced colorectal cancer. Experience from two recent large phase III trials. Br. J. Cancer 77(Suppl. 2):9-14; 1998.
-
(1998)
Br. J. Cancer
, vol.77
, Issue.2 SUPPL.
, pp. 9-14
-
-
Anderson, H.1
Palmer, M.K.2
-
11
-
-
0031671255
-
Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer
-
Tomudex Colorectal Cancer Study Group.
-
Cocconi, G.; Cunningham, D.; Van Cutsem, E.; Francois, E.; Gustavsson, B.; van Hazel, G.; Kerr, D.; Possinger, K.; Hietschold, S. M. Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. Tomudex Colorectal Cancer Study Group. J. Clin. Oncol. 16:2943; 1998.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2943
-
-
Cocconi, G.1
Cunningham, D.2
Van Cutsem, E.3
Francois, E.4
Gustavsson, B.5
Van Hazel, G.6
Kerr, D.7
Possinger, K.8
Hietschold, S.M.9
-
12
-
-
5544237608
-
Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer
-
'Tomudex' Colorectal Cancer Study Group
-
Cunningham, D.; Zalcberg, J. R.; Rath, U.; Oliver, I.; Van Cutsem, E.; Svensson, C.; Seitz, J. F.; Harper, P.; Kerr, D.; Perez-Manga, G. Final results of a randomised trial comparing 'Tomudex' (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer. 'Tomudex' Colorectal Cancer Study Group. Ann. Oncol. 7:961-965; 1996.
-
(1996)
Ann. Oncol.
, vol.7
, pp. 961-965
-
-
Cunningham, D.1
Zalcberg, J.R.2
Rath, U.3
Oliver, I.4
Van Cutsem, E.5
Svensson, C.6
Seitz, J.F.7
Harper, P.8
Kerr, D.9
Perez-Manga, G.10
-
13
-
-
0000152038
-
Advanced coloreclal cancer: Results from the latest Tomudex comparative study
-
Harper, P. Advanced coloreclal cancer: Results from the latest Tomudex comparative study. Proc. Am. Soc. Clin. Oncol. 16:802; 1997.
-
(1997)
Proc. Am. Soc. Clin. Oncol.
, vol.16
, pp. 802
-
-
Harper, P.1
-
14
-
-
0000269364
-
Raltitrexed vs 5-fluorouacil + leucovorin in patients with advanced clorectal cancer: Results of a randomized multicenter North American Trial
-
Pazdur, R.; Vincent, M. Raltitrexed vs 5-fluorouacil + leucovorin in patients with advanced clorectal cancer: Results of a randomized multicenter North American Trial. Proc. Am. Soc. Clin. Oncol. 16:801; 1997.
-
(1997)
Proc. Am. Soc. Clin. Oncol.
, vol.16
, pp. 801
-
-
Pazdur, R.1
Vincent, M.2
-
15
-
-
0343343088
-
Combination therapy with infusional 5-FU and Tomudex for patients with advanced colorectal cancer - A phase I study
-
Harstrick, A.; Mayer, S.; Muller, C.; Hilger, R.; Dohmen, D.; Kreisel, C.; Vanhoefer, U.; Scheulen, M. E.; Wilke, H.; Seeber, S. Combination therapy with infusional 5-FU and Tomudex for patients with advanced colorectal cancer - a phase I study. Proc. Am. Soc. Clin. Oncol. 17:772; 1998.
-
(1998)
Proc. Am. Soc. Clin. Oncol.
, vol.17
, pp. 772
-
-
Harstrick, A.1
Mayer, S.2
Muller, C.3
Hilger, R.4
Dohmen, D.5
Kreisel, C.6
Vanhoefer, U.7
Scheulen, M.E.8
Wilke, H.9
Seeber, S.10
-
16
-
-
0033372553
-
Phase I and pharmacokinetic study of tomudex combined with 5-fluorouracil plus levofolinic acid in advanced head and neck cancer and colorectal cancer
-
Caponigro, F.; Avallone, A.; McLeod, H.; Carteni, G.; De Vita, F.; Casaretti, R.; Morsman, J.; Blackie, R.; Budillon, A.; De Lucia, L.; Gravina, A.; Catalano, G.; Comelia, P.; Comella, G. Phase I and pharmacokinetic study of tomudex combined with 5-fluorouracil plus levofolinic acid in advanced head and neck cancer and colorectal cancer. Clin. Cancer Res. 5:3948-3955; 1999.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 3948-3955
-
-
Caponigro, F.1
Avallone, A.2
McLeod, H.3
Carteni, G.4
De Vita, F.5
Casaretti, R.6
Morsman, J.7
Blackie, R.8
Budillon, A.9
De Lucia, L.10
Gravina, A.11
Catalano, G.12
Comelia, P.13
Comella, G.14
-
17
-
-
0033103659
-
Raltitrexed (Tomudex) in combination with 5-fluorouracil for the treatment of patients with advanced colorectal cancer: Preliminary results from phase I clinical trials
-
Schwartz, G. K.; Harstrick, A.; Gonzalez Baron, M. Raltitrexed (Tomudex) in combination with 5-fluorouracil for the treatment of patients with advanced colorectal cancer: Preliminary results from phase I clinical trials. Eur. J. Cancer 35(Suppl. 1):9-13; 1999.
-
(1999)
Eur. J. Cancer
, vol.35
, Issue.1 SUPPL.
, pp. 9-13
-
-
Schwartz, G.K.1
Harstrick, A.2
Gonzalez Baron, M.3
-
18
-
-
0001826735
-
Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidylate synthase inhibitor tomudex (ZD1694)
-
Harstrick, A.; Schleucher, N.; Gonzales, A.; Schmidt, C.; Hoffman, A.; Wilke, H.; Rustum, Y.; Seeber, S. Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidylate synthase inhibitor tomudex (ZD1694). Eur. J. Cancer. 31A(Suppl. 5):S30; 1995.
-
(1995)
Eur. J. Cancer.
, vol.31 A
, Issue.5 SUPPL.
-
-
Harstrick, A.1
Schleucher, N.2
Gonzales, A.3
Schmidt, C.4
Hoffman, A.5
Wilke, H.6
Rustum, Y.7
Seeber, S.8
-
19
-
-
0344726139
-
Biochemical basis for the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil
-
Van der Wilt, C. L.; Pinedo, H. M.; Kuiper, C. M.; Smid, K.; Peters, G. J. Biochemical basis for the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil. Proc. Am. Assoc. Cancer Res. 36:2260; 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 2260
-
-
Van Der Wilt, C.L.1
Pinedo, H.M.2
Kuiper, C.M.3
Smid, K.4
Peters, G.J.5
-
20
-
-
28244490061
-
Pretreatment of colon carcinoma cells to D1694 (Tomudex) markedly enhances 5-fluorouracil cytotoxicity
-
Chang, Y. M.; Zielinski, Z.; Izzo, J.; Porubcin, M.; Bertino, J. R. Pretreatment of colon carcinoma cells to D1694 (Tomudex) markedly enhances 5-fluorouracil cytotoxicity. Proc. Am. Assoc. Cancer Res. 35:1966; 1996.
-
(1996)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 1966
-
-
Chang, Y.M.1
Zielinski, Z.2
Izzo, J.3
Porubcin, M.4
Bertino, J.R.5
-
21
-
-
0013485748
-
Combination studies with Tomudex and 5-fluorouracil in human colon tumour cell lines
-
Kimbel, R.; Brunton, L.; Jackman, A. L. Combination studies with Tomudex and 5-fluorouracil in human colon tumour cell lines. Br. J. Cancer 73(Suppl. 16):P12; 1996.
-
(1996)
Br. J. Cancer
, vol.73
, Issue.16 SUPPL.
-
-
Kimbel, R.1
Brunton, L.2
Jackman, A.L.3
-
22
-
-
0031937913
-
Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity
-
Longo, G. S.; Izzo, J.; Chang, Y. M.; Tong, W. P.; Zielinski, Z.; Gorlick, R.; Chou, T. C.; Bcrtino, J. R. Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity. Clin. Cancer Res. 4:469-473; 1998.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 469-473
-
-
Longo, G.S.1
Izzo, J.2
Chang, Y.M.3
Tong, W.P.4
Zielinski, Z.5
Gorlick, R.6
Chou, T.C.7
Bcrtino, J.R.8
-
23
-
-
0026409196
-
In vitro effects of amsacrine in combination with other anticancer agents
-
Kano, Y.; Sakamoto, S.; Kasahara, T.; Akutsu, M.; Inoue, Y.; Miura, Y. In vitro effects of amsacrine in combination with other anticancer agents. Leukemia Res. 15:1059-1064; 1991.
-
(1991)
Leukemia Res.
, vol.15
, pp. 1059-1064
-
-
Kano, Y.1
Sakamoto, S.2
Kasahara, T.3
Akutsu, M.4
Inoue, Y.5
Miura, Y.6
-
24
-
-
0018425119
-
Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
-
Steel, G. G.; Peckham, M. J. Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity. Int. J. Radial. Oncol. 5:8-91; 1979.
-
(1979)
Int. J. Radial. Oncol.
, vol.5
, pp. 8-91
-
-
Steel, G.G.1
Peckham, M.J.2
-
25
-
-
0023873482
-
Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture
-
Kano, Y.; Ohnuma, T.; Okano, T.; Holland, J. F. Effects of vincristine in combination with methotrexate and other antitumor agents in human acute lymphoblastic leukemia cells in culture. Cancer Res. 48:351-356; 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 351-356
-
-
Kano, Y.1
Ohnuma, T.2
Okano, T.3
Holland, J.F.4
-
26
-
-
0026587170
-
Effects of CPT-11 in combination with other anticancer agents in culture
-
Kano, Y.; Suzuki, K.; Akutsu, M.; Suda, K.; Inoue, Y.; Yoshida, M.; Sakamoto, S.; Miura, Y. Effects of CPT-11 in combination with other anticancer agents in culture. Int. J. Cancer 50:604-609; 1992.
-
(1992)
Int. J. Cancer
, vol.50
, pp. 604-609
-
-
Kano, Y.1
Suzuki, K.2
Akutsu, M.3
Suda, K.4
Inoue, Y.5
Yoshida, M.6
Sakamoto, S.7
Miura, Y.8
-
27
-
-
0031832323
-
In vitro schedule-dependent interaction between paclitaxel and SN-38 (the active metabolite of irinotecan) in human carcinoma cell lines
-
Kano, Y.; Akutsu, M.; Tsunoda, S.; Suzuki, K.; Adachi, K. In vitro schedule-dependent interaction between paclitaxel and SN-38 (the active metabolite of irinotecan) in human carcinoma cell lines. Cancer Chemother. Pharmacol. 42:91-98; 1998.
-
(1998)
Cancer Chemother. Pharmacol.
, vol.42
, pp. 91-98
-
-
Kano, Y.1
Akutsu, M.2
Tsunoda, S.3
Suzuki, K.4
Adachi, K.5
-
28
-
-
0345588453
-
Molecular mechanisms of the synergistic sequential administration of ZD1694 (Tomudex) followed by Fura in colon carcinoma cells
-
Izzo, J.; Zielinski, Z.; Chang, Y. M.; Bertino, J. R. Molecular mechanisms of the synergistic sequential administration of ZD1694 (Tomudex) followed by Fura in colon carcinoma cells. Proc. Am. Assoc. Cancer Res. 36:2272; 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 2272
-
-
Izzo, J.1
Zielinski, Z.2
Chang, Y.M.3
Bertino, J.R.4
-
29
-
-
0028020864
-
Flow cytometric analysis of cell-killing actions of 5-fluorouracil in human colorectal cancer cells
-
Inaba, M.; Mitsuhashi, J. Flow cytometric analysis of cell-killing actions of 5-fluorouracil in human colorectal cancer cells. Oncol. Res. 6:303-309; 1994.
-
(1994)
Oncol. Res.
, vol.6
, pp. 303-309
-
-
Inaba, M.1
Mitsuhashi, J.2
-
30
-
-
0026637845
-
Novel mechanisms of resistance to 5-fluorouracil in human colon cancer (HT-8) sublines
-
Aschele, C.; Sobrero, A.; Faderan, M. A.; Bertino, J. R. Novel mechanisms of resistance to 5-fluorouracil in human colon cancer (HT-8) sublines. Cancer Res. 52:1855-1864; 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 1855-1864
-
-
Aschele, C.1
Sobrero, A.2
Faderan, M.A.3
Bertino, J.R.4
-
31
-
-
0024847290
-
What is synergy?
-
Berenbaum, M. C. What is synergy? Pharmacol. Rev. 41:93-141; 1988.
-
(1988)
Pharmacol. Rev.
, vol.41
, pp. 93-141
-
-
Berenbaum, M.C.1
-
32
-
-
0028776770
-
Role of modelling in joint action studies
-
Frey, C. M. Role of modelling in joint action studies. J. Natl: Cancer Inst. 86:1493-1495; 1994.
-
(1994)
J. Natl: Cancer Inst.
, vol.86
, pp. 1493-1495
-
-
Frey, C.M.1
-
33
-
-
0029036955
-
The search for synergy: A critical review from a response surface perspective
-
Greco, W. R.; Bravo, G.; Parsons, J. C. The search for synergy: A critical review from a response surface perspective. Pharmacol. Rev. 47:331-385; 1995.
-
(1995)
Pharmacol. Rev.
, vol.47
, pp. 331-385
-
-
Greco, W.R.1
Bravo, G.2
Parsons, J.C.3
-
34
-
-
0002370109
-
Synergism, antagonism, and potentiation of chemotherapy
-
Chou, T. C.; Rideout, D. C., eds. San Diego: Academic Press
-
Rideout, D. C.; Chou, T. C. Synergism, antagonism, and potentiation of chemotherapy. In: Chou, T. C.; Rideout, D. C., eds. Synergism and antagonism in chemothrapy. San Diego: Academic Press; 1991:3-60.
-
(1991)
Synergism and Antagonism in Chemothrapy
, pp. 3-60
-
-
Rideout, D.C.1
Chou, T.C.2
-
35
-
-
0001458215
-
Effect of more than one inhibitor
-
New York: Academic Press
-
Webb, J. L. Effect of more than one inhibitor. In: Enzymes and metabolic inhibitors, vol. 1. New York: Academic Press; 1963: 66-79.
-
(1963)
Enzymes and Metabolic Inhibitors
, vol.1
, pp. 66-79
-
-
Webb, J.L.1
-
36
-
-
0001663843
-
The problem of synergism and antagonism of combined drugs
-
Loewe, S. The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 3:285-290; 1953.
-
(1953)
Arzneimittelforschung
, vol.3
, pp. 285-290
-
-
Loewe, S.1
-
37
-
-
0028153260
-
Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human tcratocarcinoma cell growth: A rational approach to clinical protocol design
-
Chou, T. C.; Motzer, R. J.; Tong, Y.; Bosl, G. J. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human tcratocarcinoma cell growth: A rational approach to clinical protocol design. J. Natl. Cancer Inst. 86: 1517-1524; 1994.
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 1517-1524
-
-
Chou, T.C.1
Motzer, R.J.2
Tong, Y.3
Bosl, G.J.4
|