-
1
-
-
0031888857
-
Mature results from three large controlled studies with raltitrexed (`Tomudex')
-
Cunningham D. Mature results from three large controlled studies with raltitrexed (`Tomudex'). Br. J. Cancer. 77(Suppl. 2):1998;15-21.
-
(1998)
Br. J. Cancer
, vol.77
, Issue.SUPPL. 2
, pp. 15-21
-
-
Cunningham, D.1
-
2
-
-
0027531536
-
Recent advances in the treatment of advanced colorectal cancer
-
Kemeny N., Lokich J.J., Anderson N., Ahlgren J.D. Recent advances in the treatment of advanced colorectal cancer. Cancer. 71:1993;9-18.
-
(1993)
Cancer
, vol.71
, pp. 9-18
-
-
Kemeny, N.1
Lokich, J.J.2
Anderson, N.3
Ahlgren, J.D.4
-
3
-
-
0028351657
-
Chemotherapy for colorectal cancer
-
Moertel C.G. Chemotherapy for colorectal cancer. N. Engl. J. Med. 330:1994;1136-1142.
-
(1994)
N. Engl. J. Med.
, vol.330
, pp. 1136-1142
-
-
Moertel, C.G.1
-
4
-
-
9044245305
-
ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer
-
Zalcberg J.R., Cunningham D., Van Cutsem E.et al. ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. J. Clin. Oncol. 14:1996;716-721.
-
(1996)
J. Clin. Oncol.
, vol.14
, pp. 716-721
-
-
Zalcberg, J.R.1
Cunningham, D.2
Van Cutsem, E.3
-
5
-
-
0031915084
-
Raltitrexed: A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer
-
Gunasekara N.S., Faulds D. Raltitrexed: A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer. Drugs. 55:1998;423-435.
-
(1998)
Drugs
, vol.55
, pp. 423-435
-
-
Gunasekara, N.S.1
Faulds, D.2
-
7
-
-
0031671255
-
Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer
-
Cocconi G., Cunningham D., Van Cutsem E.et al. Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. J. Clin. Oncol. 16:1998;2943-2952.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2943-2952
-
-
Cocconi, G.1
Cunningham, D.2
Van Cutsem, E.3
-
8
-
-
0024539308
-
A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study
-
Lokich J.J., Ahlgren J.D., Gullo J.J., Philips J.A., Fryer J.G. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study. J. Clin. Oncol. 7:1989;425-432.
-
(1989)
J. Clin. Oncol.
, vol.7
, pp. 425-432
-
-
Lokich, J.J.1
Ahlgren, J.D.2
Gullo, J.J.3
Philips, J.A.4
Fryer, J.G.5
-
9
-
-
0344109583
-
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
-
Meta-analysis Group in Cancer
-
Meta-analysis Group in Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998, 16, 301-308.
-
(1998)
J Clin Oncol
, vol.16
, pp. 301-308
-
-
-
10
-
-
0026637845
-
Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules
-
Aschele C., Sobrero A., Faderan M.A., Bertino J.R. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res. 52:1992;1855-1864.
-
(1992)
Cancer Res.
, vol.52
, pp. 1855-1864
-
-
Aschele, C.1
Sobrero, A.2
Faderan, M.A.3
Bertino, J.R.4
-
11
-
-
0031937913
-
Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity
-
Longo G.S.A., Izzo J., Chang Y.M.et al. Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity. Clin. Cancer Res. 4:1998;469-473.
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 469-473
-
-
Longo, G.S.A.1
Izzo, J.2
Chang, Y.M.3
-
12
-
-
0001826735
-
Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidylate synthase inhibitor `Tomudex' (D1694)
-
Harstrick A., Schleucher N., Gonzales A.et al. Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidylate synthase inhibitor `Tomudex' (D1694). Eur. J. Cancer. 31A(Suppl. 5):1995;S30.
-
(1995)
Eur. J. Cancer
, vol.31 A
, Issue.SUPPL. 5
-
-
Harstrick, A.1
Schleucher, N.2
Gonzales, A.3
-
13
-
-
0000033490
-
Biochemical basis for the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil
-
A2260
-
Van der Wilt CL, Pinedo HM, Kuiper CM, Smid K, Peters GJ. Biochemical basis for the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil. Proc Am Assoc Cancer Res 1995, 36, 379 (A2260).
-
(1995)
Proc Am Assoc Cancer Res
, vol.36
, pp. 379
-
-
Van der Wilt, C.L.1
Pinedo, H.M.2
Kuiper, C.M.3
Smid, K.4
Peters, G.J.5
-
14
-
-
0013514224
-
The effect of `Tomudex' on dihydropyrimidine dehydrogenase activity
-
abstract 4133
-
Yan JM, Lu ZH, Shao LN, Diasio RB. The effect of `Tomudex' on dihydropyrimidine dehydrogenase activity. Proc Am Assoc Cancer Res 1997, 38 (abstract 4133).
-
(1997)
Proc Am Assoc Cancer Res
, pp. 38
-
-
Yan, J.M.1
Lu, Z.H.2
Shao, L.N.3
Diasio, R.B.4
-
15
-
-
0000911677
-
Interim results of a phase I trial suggest that `Tomudex' (raltitrexed) may act synergistically with 5-FU in patients with advanced colorectal cancer (CRC)
-
abstract 171P
-
Schwartz GK, Bertino JL, Kemeny N, et al. Interim results of a phase I trial suggest that `Tomudex' (raltitrexed) may act synergistically with 5-FU in patients with advanced colorectal cancer (CRC). Ann Oncol 1998, 9(Suppl. 4), 36 (abstract 171P).
-
(1998)
Ann Oncol
, vol.9
, Issue.SUPPL. 4
, pp. 36
-
-
Schwartz, G.K.1
Bertino, J.L.2
Kemeny, N.3
-
16
-
-
0001326060
-
Combination therapy with infusional 5-FU and `Tomudex' for patients (pts) with advanced colorectal cancer - A phase I study
-
abstract 170P
-
Harstrick A, Mayer S, Hilger R, et al. Combination therapy with infusional 5-FU and `Tomudex' for patients (pts) with advanced colorectal cancer - A phase I study. Ann Oncol 1998, 9(Suppl. 4), 35 (abstract 170P).
-
(1998)
Ann Oncol
, vol.9
, Issue.SUPPL. 4
, pp. 35
-
-
Harstrick, A.1
Mayer, S.2
Hilger, R.3
-
17
-
-
0001139165
-
Phase I trial of ZD 1694 (Tomudex), a direct inhibitor of thymidylate synthase
-
A241
-
Sorensen JM, Jordan E, Grem JL, et al. Phase I trial of ZD 1694 (Tomudex), a direct inhibitor of thymidylate synthase. Ann Oncol 1994, 5(Suppl. 5), 132 (A241).
-
(1994)
Ann Oncol
, vol.5
, Issue.SUPPL. 5
, pp. 132
-
-
Sorensen, J.M.1
Jordan, E.2
Grem, J.L.3
-
18
-
-
0026006962
-
Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
-
Poon M.A., O'Connell M.J., Wieand H.S.et al. Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J. Clin. Oncol. 9:1991;1967-1972.
-
(1991)
J. Clin. Oncol.
, vol.9
, pp. 1967-1972
-
-
Poon, M.A.1
O'Connell, M.J.2
Wieand, H.S.3
-
19
-
-
0025979845
-
A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorectal carcinoma
-
Ardalan B., Chua L., Tian E.M.et al. A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorectal carcinoma. J. Clin. Oncol. 9:1991;625-630.
-
(1991)
J. Clin. Oncol.
, vol.9
, pp. 625-630
-
-
Ardalan, B.1
Chua, L.2
Tian, E.M.3
-
20
-
-
0031879628
-
Uracil-tegafur in gastric carcinoma: A comprehensive review
-
Takiuchi H., Ajani J.A. Uracil-tegafur in gastric carcinoma: A comprehensive review. J. Clin. Oncol. 16:1998;2877-2885.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2877-2885
-
-
Takiuchi, H.1
Ajani, J.A.2
|