메뉴 건너뛰기




Volumn 35, Issue SUPPL. 1, 1999, Pages S9-

Raltitrexed (Tomudex(TM)) in combination with 5-fluorouracil for the treatment of patients with advanced colorectal cancer: Preliminary results from phase I clinical trials

Author keywords

5 fluorouracil; Chemotherapy; Colorectal cancer; Raltitrexed; Tegafur uracil

Indexed keywords

FLUOROURACIL; RALTITREXED; ANTINEOPLASTIC AGENT; QUINAZOLINE DERIVATIVE; THIOPHENE DERIVATIVE;

EID: 0033103659     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0959-8049(99)00042-8     Document Type: Conference Paper
Times cited : (20)

References (21)
  • 1
    • 0031888857 scopus 로고    scopus 로고
    • Mature results from three large controlled studies with raltitrexed (`Tomudex')
    • Cunningham D. Mature results from three large controlled studies with raltitrexed (`Tomudex'). Br. J. Cancer. 77(Suppl. 2):1998;15-21.
    • (1998) Br. J. Cancer , vol.77 , Issue.SUPPL. 2 , pp. 15-21
    • Cunningham, D.1
  • 2
    • 0027531536 scopus 로고
    • Recent advances in the treatment of advanced colorectal cancer
    • Kemeny N., Lokich J.J., Anderson N., Ahlgren J.D. Recent advances in the treatment of advanced colorectal cancer. Cancer. 71:1993;9-18.
    • (1993) Cancer , vol.71 , pp. 9-18
    • Kemeny, N.1    Lokich, J.J.2    Anderson, N.3    Ahlgren, J.D.4
  • 3
    • 0028351657 scopus 로고
    • Chemotherapy for colorectal cancer
    • Moertel C.G. Chemotherapy for colorectal cancer. N. Engl. J. Med. 330:1994;1136-1142.
    • (1994) N. Engl. J. Med. , vol.330 , pp. 1136-1142
    • Moertel, C.G.1
  • 4
    • 9044245305 scopus 로고    scopus 로고
    • ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer
    • Zalcberg J.R., Cunningham D., Van Cutsem E.et al. ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. J. Clin. Oncol. 14:1996;716-721.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 716-721
    • Zalcberg, J.R.1    Cunningham, D.2    Van Cutsem, E.3
  • 5
    • 0031915084 scopus 로고    scopus 로고
    • Raltitrexed: A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer
    • Gunasekara N.S., Faulds D. Raltitrexed: A review of its pharmacological properties and clinical efficacy in the management of advanced colorectal cancer. Drugs. 55:1998;423-435.
    • (1998) Drugs , vol.55 , pp. 423-435
    • Gunasekara, N.S.1    Faulds, D.2
  • 6
    • 0024595925 scopus 로고
    • Clinical pharmacology of 5-fluorouracil
    • Diasio R.B., Harris B.E. Clinical pharmacology of 5-fluorouracil. Clin. Pharmacokinetics. 16:1989;215-237.
    • (1989) Clin. Pharmacokinetics , vol.16 , pp. 215-237
    • Diasio, R.B.1    Harris, B.E.2
  • 7
    • 0031671255 scopus 로고    scopus 로고
    • Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer
    • Cocconi G., Cunningham D., Van Cutsem E.et al. Open, randomized, multicenter trial of raltitrexed versus fluorouracil plus high-dose leucovorin in patients with advanced colorectal cancer. J. Clin. Oncol. 16:1998;2943-2952.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2943-2952
    • Cocconi, G.1    Cunningham, D.2    Van Cutsem, E.3
  • 8
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study
    • Lokich J.J., Ahlgren J.D., Gullo J.J., Philips J.A., Fryer J.G. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study. J. Clin. Oncol. 7:1989;425-432.
    • (1989) J. Clin. Oncol. , vol.7 , pp. 425-432
    • Lokich, J.J.1    Ahlgren, J.D.2    Gullo, J.J.3    Philips, J.A.4    Fryer, J.G.5
  • 9
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • Meta-analysis Group in Cancer
    • Meta-analysis Group in Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998, 16, 301-308.
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 10
    • 0026637845 scopus 로고
    • Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules
    • Aschele C., Sobrero A., Faderan M.A., Bertino J.R. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules. Cancer Res. 52:1992;1855-1864.
    • (1992) Cancer Res. , vol.52 , pp. 1855-1864
    • Aschele, C.1    Sobrero, A.2    Faderan, M.A.3    Bertino, J.R.4
  • 11
    • 0031937913 scopus 로고    scopus 로고
    • Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity
    • Longo G.S.A., Izzo J., Chang Y.M.et al. Pretreatment of colon carcinoma cells with Tomudex enhances 5-fluorouracil cytotoxicity. Clin. Cancer Res. 4:1998;469-473.
    • (1998) Clin. Cancer Res. , vol.4 , pp. 469-473
    • Longo, G.S.A.1    Izzo, J.2    Chang, Y.M.3
  • 12
    • 0001826735 scopus 로고
    • Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidylate synthase inhibitor `Tomudex' (D1694)
    • Harstrick A., Schleucher N., Gonzales A.et al. Interactions and cross resistance patterns between various schedules of 5-FU and the new, folate-based thymidylate synthase inhibitor `Tomudex' (D1694). Eur. J. Cancer. 31A(Suppl. 5):1995;S30.
    • (1995) Eur. J. Cancer , vol.31 A , Issue.SUPPL. 5
    • Harstrick, A.1    Schleucher, N.2    Gonzales, A.3
  • 13
    • 0000033490 scopus 로고
    • Biochemical basis for the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil
    • A2260
    • Van der Wilt CL, Pinedo HM, Kuiper CM, Smid K, Peters GJ. Biochemical basis for the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil. Proc Am Assoc Cancer Res 1995, 36, 379 (A2260).
    • (1995) Proc Am Assoc Cancer Res , vol.36 , pp. 379
    • Van der Wilt, C.L.1    Pinedo, H.M.2    Kuiper, C.M.3    Smid, K.4    Peters, G.J.5
  • 14
    • 0013514224 scopus 로고    scopus 로고
    • The effect of `Tomudex' on dihydropyrimidine dehydrogenase activity
    • abstract 4133
    • Yan JM, Lu ZH, Shao LN, Diasio RB. The effect of `Tomudex' on dihydropyrimidine dehydrogenase activity. Proc Am Assoc Cancer Res 1997, 38 (abstract 4133).
    • (1997) Proc Am Assoc Cancer Res , pp. 38
    • Yan, J.M.1    Lu, Z.H.2    Shao, L.N.3    Diasio, R.B.4
  • 15
    • 0000911677 scopus 로고    scopus 로고
    • Interim results of a phase I trial suggest that `Tomudex' (raltitrexed) may act synergistically with 5-FU in patients with advanced colorectal cancer (CRC)
    • abstract 171P
    • Schwartz GK, Bertino JL, Kemeny N, et al. Interim results of a phase I trial suggest that `Tomudex' (raltitrexed) may act synergistically with 5-FU in patients with advanced colorectal cancer (CRC). Ann Oncol 1998, 9(Suppl. 4), 36 (abstract 171P).
    • (1998) Ann Oncol , vol.9 , Issue.SUPPL. 4 , pp. 36
    • Schwartz, G.K.1    Bertino, J.L.2    Kemeny, N.3
  • 16
    • 0001326060 scopus 로고    scopus 로고
    • Combination therapy with infusional 5-FU and `Tomudex' for patients (pts) with advanced colorectal cancer - A phase I study
    • abstract 170P
    • Harstrick A, Mayer S, Hilger R, et al. Combination therapy with infusional 5-FU and `Tomudex' for patients (pts) with advanced colorectal cancer - A phase I study. Ann Oncol 1998, 9(Suppl. 4), 35 (abstract 170P).
    • (1998) Ann Oncol , vol.9 , Issue.SUPPL. 4 , pp. 35
    • Harstrick, A.1    Mayer, S.2    Hilger, R.3
  • 17
    • 0001139165 scopus 로고
    • Phase I trial of ZD 1694 (Tomudex), a direct inhibitor of thymidylate synthase
    • A241
    • Sorensen JM, Jordan E, Grem JL, et al. Phase I trial of ZD 1694 (Tomudex), a direct inhibitor of thymidylate synthase. Ann Oncol 1994, 5(Suppl. 5), 132 (A241).
    • (1994) Ann Oncol , vol.5 , Issue.SUPPL. 5 , pp. 132
    • Sorensen, J.M.1    Jordan, E.2    Grem, J.L.3
  • 18
    • 0026006962 scopus 로고
    • Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
    • Poon M.A., O'Connell M.J., Wieand H.S.et al. Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J. Clin. Oncol. 9:1991;1967-1972.
    • (1991) J. Clin. Oncol. , vol.9 , pp. 1967-1972
    • Poon, M.A.1    O'Connell, M.J.2    Wieand, H.S.3
  • 19
    • 0025979845 scopus 로고
    • A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorectal carcinoma
    • Ardalan B., Chua L., Tian E.M.et al. A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorectal carcinoma. J. Clin. Oncol. 9:1991;625-630.
    • (1991) J. Clin. Oncol. , vol.9 , pp. 625-630
    • Ardalan, B.1    Chua, L.2    Tian, E.M.3
  • 20
    • 0031879628 scopus 로고    scopus 로고
    • Uracil-tegafur in gastric carcinoma: A comprehensive review
    • Takiuchi H., Ajani J.A. Uracil-tegafur in gastric carcinoma: A comprehensive review. J. Clin. Oncol. 16:1998;2877-2885.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2877-2885
    • Takiuchi, H.1    Ajani, J.A.2
  • 21
    • 0025242135 scopus 로고
    • Oral carmofur in advanced gastrointestinal cancer
    • Grohn P., Heinonen E., Kumpulainen E.et al. Oral carmofur in advanced gastrointestinal cancer. Am. J. Clin. Oncol. 13:1990;477-479.
    • (1990) Am. J. Clin. Oncol. , vol.13 , pp. 477-479
    • Grohn, P.1    Heinonen, E.2    Kumpulainen, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.