Radiation-induced apoptosis of human prostate cancer cells is independent of mutant p53 overexpression

Anticancer Research

Volumn 18, Issue 2 A, 1998, Pages 897-905

  Kyprianou, Natasha ^a,b   Rock, Steven ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Ionizing radiation; p53; Prostate cancer

Indexed keywords

DNA FRAGMENT; MESSENGER RNA; NEOMYCIN; PROTEIN P53; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; MALE; MOLECULAR CLONING; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION;

EID: 0031840913     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Wingo PA, Tong T, Bolden S: Cancer Statistics, C.A. Cancer J Clin 45: 8-30, 1995.
2. Raghavan D: Non-hormone chemotherapy for prostate cancer: Principles of treatment and application of the testing of new drugs. Sem Oncol 15: 371-389, 1988.
3. Schellhamer PF: Radiation therapy for localized prostate cancer. IN Monographs in Urology, Vol.15, (Stamey, T.; ed.), 1994.
4. Zelefsky MJ, Leibel SA, Burman CM, Kutcher GJ, Harrison A, Happersett L and Fuks Z: Neoadjuvant hormonal therapy improves the therapeutic ratio in patients with bulky prostatic disease treated with three-deminsional conformal radiation therapy. Int J Radiat Oncol Biol Phys 29: 755-761, 1994.
5. Kyprianou N Apoptosis: Therapeutic significance in the treatment of androgen- dependent and androgen-independent prostate cancer. World J Urol 13: 299-303, 1994.
6. Sklar GN, Eddy HA, Jacobs SC and Kyprianou N: Combined antitumor effect of suramin plus irradiation in human prostate cancer cells: the role of apoptosis. J Urol 150: 1526-1532, 1993.
7. Stephens LC, Hunter NR, Ang KK, Milas L and Meyn RE: Development of apoptosis in irradiated murine tumors as a function of time and dose. Radiat Res 135: 75-80, 1993.
8. Soldatenkov VA, Prasad S, Notario V and Dritschilo A: Radiation-induced apoptosis of Ewing's sarcoma cells: DNA fragmentation and proteolysis of poly(ADP-ribose) polymarase. Cancer Res 55: 4240-4242, 1995.
9. Kuerbitz SJ, Plunkett BS, Walsh WV and Kastan MB: Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89: 7491-7495, 1992.
10. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Tyler J, Walsh WV, Plunkett BS, Vogestein B and Fornace AJ: A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia. Cell 71: 587-595, 1992.
11. McIlwrath AJ, Vasey PA, Ross GM and Brown R: Cell-cycle arrest and radiosensitivity of human tumor cell lines: Dependence on wild-type p53 for radiosensitivity. Cancer Res 54: 3718-3722, 1994.
12. Yonish-Rouch E, Resnitzky D, Lotem J, Sachs L, Kimchi A and Oren M: Wild-type p53 induces apoptosis of myeloid leukemia cells that is inhibited by interleukin-6. Nature 352: 345-347, 1991.
13. Shaw W, Bovey R, Tardy S, Sahli R, Sordat B and Costa J: Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Nat Acad Sci 89: 4495-4499, 1992.
14. Lowe SW, Schmitt EM, Smith SW, Osborne BA and Jacks T: p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362: 847-849, 1993.
15. Lowe SW, Ruley HE, Jacks T and Housman DE: p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74: 957-967, 1993.
16. Hollstein M, Sidransky D, Vogelstein B and Harris CC: p53 mutations in human cancers. Science 253: 49-53, 1991.
17. Lee JM and Bernstein A: p53 mutations increase resistance to ionizing-irradiation. Proc Natl Acad Sci USA 90: 5742-5746, 1993.
18. O'Connor PM, Jackman J, Jondle D, Bhatia K, Magrath I and Kohn KW: Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines. Cancer Res 53: 4776-4780, 1993.
19. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper MD and Wyllie AJ: Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362: 849-852, 1993.
20. Fukunaga-Johnson N, Ryan J-J, Wicha M, Nunez G and Clarke M-F: Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation induced cell death. Carcinogenesis 16: 1761-1767, 1995.
21. Gartenhaus RB, Wang P and Hoffman P: Induction of the WAF-1/CIP1 protein and apoptosis in human T-cell leukemia virus type I-transformed lymphocytes after treatment with adriamycin by using a p53-independent pathway. Proc Natl Acad Sci USA 93: 265-268, 1996.
22. Colombel M, Olsson CA, Ng P-Y and Buttyan R: Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle. Cancer Res 52: 4313-4319, 1992.
23. Berges RS, Furuya Y, Jacks T, English H and Isaacs JT: Cell proliferation, DNA repair, and p53 function are not required for programmed death of prostatic glandular cells induced by androgen ablation. Proc Natl Acad Sci USA 90: 8910-8914, 1993
24. Colombel MC, Radvanyi F, Blanche Mm Abbou C, Buttyan R, Donehower LA, Chopin D and Thiery JP: Androgen-supressed apoptosis is modified in p53 deficient mice. Oncogene 10: 1269-1273, 1995.
25. Isaacs WB, Carter BS and Ewing CM: Wild-type p53 suppresses growth of human prostate cancer cells contamg mutant p53 alleles. Cancer Res 57: 4716-4720, 1991.
26. Bookstein R, MacGrogan D, Milsenbek SG, Sharkoy F and Allred DC: p53 is mutated in subset of advanced prostate cancers. Cancer Res 53: 3369-3373, 1993.
27. Navone NM, Troncosco P, Pisters LL, Goodrow TL, Palmer JL, Nichols WW, von Eschenbach AC and Conti CJ: p53 protein accumulation and gene mutation in the progression of human prostate carcinoma. J Natl Cancer Instit 85: 1657-1661, 1994.
28. Kyprianou N, King ED, Bradbury D and Rhee JG: bcl-2 overexpression delays radiation-induced apoptosis without affecting the clonogenic survival of human prostate cancer cells. Int J Cancer 70: 341-348, 1997.
29. Kyprianou N and Issacs JT: Expression of transforming growth factor-B in rat ventral prostate during castration-induced programmed cell death. Mol Endocrinol 3: 1515-1522, 1989.
30. Borner MM, Myers CE, Sartor O, Sei Y, Toko T, Trepel JB and Schneider E: Drug-induced apoptosis is not neccessarily dependent on macromolecular synthesis or proliferation in the p53-negative human prostate cancer cell line PC-3. Cancer Res 55: 2122-2128, 1995.
31. Slicehenmyer NJ, Nelson WG, Slebos RJ and Kastan MB: Loss of p53-associated G1 checkpoint does not decrease cell survival following DNA damage. Cancer Res 53: 4164-4168, 1994.
32. Jung M, Notario V and Dritchilo A: Mutations in the p53 gene in radiation-sensitive and resistant human squamous carcinoma cells. Cancer Res 52: 6390-6393, 1992.
33. Nagasowa H, Li C-Y, Maki CG, Imrich AC and Little JB: Relationship between radiation-induced G1 phase and p53 function in human tumor cells. Cancer Res 55: 1842-1846, 1995.
34. Fan S, El-Deiry WAS, Bae I, Freeman J, Jondle D, Bhatia K, Fornace AC, Magrath IJ, Kohn KW and O'Connor PM: p53 mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 54: 5824-5830, 1994.
35. Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA Jr, Butel JS and Bradley A: Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356: 215-221, 1992.
36. Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP and Hall PA: The role of p53 in spontaneous and radiation-induced apoptosis in the gastro inestinal tract of normal and p53 deficient mice. Cancer Res 54: 614-617, 1994.
37. Dulic V, Kaufman WK, Wilson SJ, Tisty TD, Lees E, Harper JW, Elledge SJ and Reed IS: p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76: 1013-1023, 1994.