Pseudocomplementary strategy strengthens PNA therapeutic potential

Drug Discovery Today

Volumn 5, Issue 12, 2000, Pages 538-540

  Senior, Kathryn ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DOUBLE STRANDED DNA; PEPTIDE NUCLEIC ACID; TELOMERASE;

DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION; HUMAN; SHORT SURVEY;

EID: 0034565945     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01586-5     Document Type: Short Survey

References (12)

1. Sequence selective recognition of DNA by strand displacement with a thymine-substituted polyamide
2. Cellular delivery of peptide nucleic acids and inhibition of human telomerase
3. Inhibition of translation and bacterial growth by peptide nucleic acid targeted to ribosomal RNA
4. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA
5. Inhibition of human telomerase activity by peptide nucleic acids
6. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
7. A new target for gene therapeutics: telomerase
8. Telomerase as a possible target for anticancer therapy
9. Double duplex invasion by peptide nucleic acid: a general principle for sequence-specific targeting of double-stranded DNA
10. Oligonucleotides containing 2-amino-adenine and 2-thiothymine act as selectively binding complementary agents
11. G/C modified oligodeoxynucleotides with selective complementarity: synthesis and hybridisation properties