Differential gene expression technologies for identifying surrogate markers of drug efficacy and toxicity

Drug Discovery Today

Volumn 5, Issue 12, 2000, Pages 560-568

  Rininger, Joseph A ^a   DiPippo, Vincent A ^a   Gould Rothberg, Bonnie E ^a  

^a CURAGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DEVELOPMENT; DRUG EFFICACY; DRUG INDUSTRY; DRUG TOXICITY; GENE EXPRESSION; METHODOLOGY; NONHUMAN; PHARMACOGENOMICS; REVIEW;

EID: 0034565911     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(00)01597-X     Document Type: Review

References (46)

1. Concise review: gene expression applied to toxicology
2. Pharmacogenomics - it's not just pharmacogenetics
3. Quantitative monitoring of gene expression patterns with a complementary DNA microarray
4. Expression monitoring by hybridization to high-density oligonucleotide arrays
5. A gene expression database for the molecular pharmacology of cancer
6. Genomic analysis
7. Technologies for detecting genetic polymorphisms in pharmacogenomics
8. Real-time RT-PCR fluorescent detection of tomato spotted wilt virus
9. Real-time quantitative PCR
10. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction
11. Gene expression analysis by transcript profiling coupled to a gene database query
12. TOGA: an automated parsing technology for analysing expression of nearly all genes
13. Serial analysis of gene expression
14. Identifying differences in mRNA expression by representational difference analysis of cDNA
15. Monitoring gene expression using DNA microarrays
16. Cluster analysis and display of genome-wide expression patterns
17. Large-scale temporal gene expression mapping of central nervous system development
18. High-density synthetic nucleotide arrays
19. Options available-from start to finish-for obtaining expression data by microarray
20. Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists
21. A transmission imaging spectrograph and microfabricated channel system for DNA analysis
22. Quantitative expression analysis of genes regulated by both obesity and leptin reveals a regulatory loop between leptin and pituitary-derived ACTH
23. WECHE: a novel hematopoietic regulatory factor
24. Expression profiling of the maize flavonoid pathway genes controlled by estradiol-inducible transcription factors CRC and P
25. Gene expression profiling in an in vitro model of angiogenesis
26. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
27. Expression profiling using cDNA microarrays
28. Gene ontology: tool for the unification of biology
29. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
30. The transcriptional program in the response of human fibroblasts to serum
31. Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations
32. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
33. Weight-reducing effects of the plasma protein encodd by the obese gene
34. Unraveling the central nervous system pathways underlying responses to leptin
35. Leptin: physiological actions
36. The biology of leptin: a review
37. Peroxisome proliferator-activated receptors: nuclear control of metabolism
38. Hepatic dysfunction associated with troglitazone
39. Troglitazone withdrawn from market
40. Effect of Mibefradil, a T-type calcium channel blocker, on morbidity and mortality in moderate to severe congestive heart failure: the MACH-1 study. Mortality Assessment in Congestive Heart failure trial
41. Calcium channel blockers in cardiac failure
42. Pharmacogenomics: translating functional genomics into rational therapeutics
43. High-throughput gene expression analysis using SAGE