Skin POMC peptides: Their actions at the human MC-1 receptor and roles in the tanning response

Pigment Cell Research

Volumn 13, Issue SUPPL. 8, 2000, Pages 125-129

  Tsatmali, Marina ^a   Ancans, Janis ^a   Yukitake, Jun ^a,b   Thody, Anthony J ^a  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

ACTH; MC 1 receptor; Melanocytes; Pigmentation; MSH

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN; CORTICOTROPIN RECEPTOR; MELANOCORTIN RECEPTOR; PEPTIDE; PROOPIOMELANOCORTIN;

ANIMAL; ARTICLE; HUMAN; MELANOCYTE; METABOLISM; PHYSIOLOGY; SKIN; SKIN PIGMENTATION;

ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; HUMANS; MELANOCYTES; PEPTIDES; PRO-OPIOMELANOCORTIN; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; SKIN; SKIN PIGMENTATION;

EID: 0034565518     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0749.13.s8.22.x     Document Type: Article

References (29)

1. Mountjoy KG, Robbins LS, Mortrud M, Cone RD. The cloning of a family of genes that encode the melanocortin receptors. Science 1992;257:1248-1251
2. Luger TA, Scholzen T, Grabbe S. The role of α-melanocyte-stimulating hormone in cutaneous biology. J Invest Dermatol Symp Proc 1997;2:87-93
3. 7α-MSH affect morphology, tyrosinase activity and melanogenesis in cultured human melanocytes. J Cell Sci 1994;107:205-211
4. Hunt G, Todd C, Kyne S, Thody AJ. ACTH stimulates melanogenesis in cultured human melanocytes. J Endocrinol 1994;140:R1-R3
5. Hunt G, Donatien PD, Lunec J, Todd C, Kyne S, Thody AJ. Cultured human melanocytes respond to MSH peptides and ACTH. Pigment Cell Res 1994;7:217-221
6. Tsatmali M, Wakamatsu K, Graham AJ, Thody AJ. Skin POMC peptides. Their binding affinities and activation of the human MC1 receptor. Ann NY Acad Sci 1999;885:466-469
7. Valverde P, Healy E, Jackson I, Rees JL, Thody AJ. Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nature Genet 1995;11:328-330
8. Smith R, Healy E, Siddiqui S, Flanagan N, Steijlen PM, Rosdahl I, Jacques JP, Rogers S, Turner R, Jackson IJ, Birch-Machin MA, Rees JL. Melanocortin 1 receptor variants in an Irish population. J Invest Dermatol 1998;111:119-122
9. Hunt G, Todd C, Thody AJ. Unresponsiveness of human epidermal melanocytes to melanocyte-stimulating hormone and its association with red hair. Mol Cell Endocrinol 1996;116:131-136
10. Thody AJ, Graham A. Does α-MSH have a role in regulating skin pigmentation in humans? Pigment Cell Res 1998;11:265-275
11. Frandberg PA, Doufexis M, Kapas S, Chhajlani V. Human pigmentation phenotype: a point mutation generates nonfunctional MSH receptor. Biochem Biophys Res Comm 1998;245:490-492
12. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet 1998;20:111-112
13. Thody AJ, Ridley K, Penny RJ, Chalmers R, Fisher C, Shuster S. MSH peptides are present in mammalian skin. Peptides 1983;4:813-816
14. Wakamatsu K, Graham A, Cook D, Thody AJ. Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigment Cell Res 1997;10:288-297
15. Lerner AB, McGuire JS. Effect of alpha- and beta-melanocyte stimulating hormone on the skin colour of man. Nature 1961;189:176-179
16. Abdel-Malek Z, Swope VB, Suzuki I, Akcali C, Harriger MD, Boyce ST, Urabe K, Hearing VJ. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci USA 1995;92:1789-1793
17. 7 α-Melanocyte-stimulating hormone increases the eumelanin:phaeomelanin ratio in cultured human melanocytes. J Invest Dermatol 1995;104:83-85
18. Lerner AB, McGuire JS. Melanocyte stimulating hormone and adrenocorticotrophic hormone: their relation to pigmentation. N Engl J Med 1964;270:539-546
19. Graham AJ. Skin peptides and their role in the regulation of human melanocytes. Ph.D. thesis. University of Newcastle upon Tyne, UK; 1997.
20. Hunt G, Donatien PD, Cresswell JE, Thody AJ. The effect of alpha-MSH on the attachment of human melanocytes to laminin and fibronectin. Evidence for specific alpha-MSH receptors on these cells. Ann NY Acad Sci 1993;680:549-551
21. Tsatmali M, Yukitake J, Thody AJ. ACTH1-17 is a more potent agonist at the human MC-1 receptor than α-MSH. Cell Mol Biol 1999;45:1029-1034
22. Donatien PD, Hunt G, Pieron C, Lunec J, Taieb A, Thody AJ. The expression of functional MSH receptors on cultured human melanocytes. Arch Dermatol Res 1992;284:424-426
23. Thody AJ, Hunt G, Donatien PD, Todd C. Human melanocytes express functional melanocyte-stimulating hormone receptors. Ann NY Acad Sci 1993;680:381-390
24. Yukitake J, Tsatmali M, Ancans J, Thody AJ. Desacetyl α-MSH is a partial agonist at the human MC1-R. Pigment Cell Res 100 Abstract 1999;Supplement 7:72
25. Chakraborty AK, Orlow SJ, Bolognia JL, Pawelek JM. Structural/functional relationships between internal and external MSH receptors: Modulation of expression in cloudman melanoma cells by UVB radiation. J Cell Physiol 1991;147:1-6
26. Chakraborty AK, Funasaka Y, Slominski A, Ermak G, Hwang J, Pawelek JM, Ichihashi M. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: Regulation by ultraviolet B. Biochim Biophys Acta 1996;1313:130-138
27. Schauer E, Trautinger F, Köck A, Schwartz A, Bhardwaj R, Simon M, Ansel JC, Schwartz T, Luger TA. Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes. J Clin Invest 1994;93:2258-2262
28. Thody AJ. α-MSH and the regulation of melanocyte function. Ann NY Acad Sci 1999;885:466-469
29. Schallreuter KU, Moore J, Tobin DJ, Gibbons NJP, Marshall HS, Jenner T, Beazley WD, Wood JM. α-MSH can control the essential cofactor 6-tetrahydrobiopterin in melanogenesis. Ann NY Acad Sci 1999;885:329-341