Deletion of a single hydrogen bonding atom from the MS2 RNA operator leads to dramatic rearrangements at the RNA-coat protein interface

Nucleic Acids Research

Volumn 28, Issue 23, 2000, Pages 4611-4616

  Grahn, Elin ^a   Stonehouse, Nicola J ^b   Adams, Chris J ^b   Fridborg, Kerstin ^a   Beigelman, Leonid ^c   Matulic Adamic, Jasenka ^c   Warriner, Stuart L ^b   Stockley, Peter G ^b   Liljas, Lars ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c Sirna Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ASPARAGINE; COAT PROTEIN; GLUTAMIC ACID; HYDROGEN; LYSINE; NUCLEIC ACID BASE; OXYGEN; PYRIDINE DERIVATIVE; PYRIMIDINE; RNA; SERINE; THREONINE; TYROSINE; URACIL;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; GENE DELETION; GENE REARRANGEMENT; HYDROGEN BOND; MS2 VIRUS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; OPERATOR GENE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA CONFORMATION; RNA STRUCTURE;

MIRIDAE; UNIDENTIFIED BACTERIOPHAGE;

EID: 0034549059     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/28.23.4611     Document Type: Article

References (32)

1. Interaction of R17 coat protein with synthetic variants of its ribonucleic acid binding site
2. Specific interaction between RNA phage coat proteins and RNA
3. Translational repression by bacteriophage MS2 coat protein does not require cysteine residues
4. Use of synthetic oligoribonucleotides to probe RNA-protein interactions in the MS2 translational operator complex
5. Crystal structure of an RNA bacteriophage coat protein-operator complex
6. The three-dimensional structure of the bacterial virus MS2
7. The three-dimensional structures of two complexes between recombinant MS2 capsids and RNA operator fragments reveal sequence-specific protein-RNA interactions
8. Crystallographic studies of RNA hairpins in complexes with recombinant MS2 capsids and implications for binding requirements
9. Crystal structure of an RNA aptamer-protein complex at 2.8 Å resolution
10. Crystal structure of a series of RNA aptamers complexed to the same protein target
11. Crystal structures of MS2 coat protein mutants in complex with wild-type RNA operator fragments
12. Altering the RNA binding specificity of a translational repressor
13. A thermodynamic analysis of the sequence-specific binding of RNA by bacteriophage MS2 coat protein
14. A general purification procedure for chemically synthesized oligoribonucleotides
15. Synthesis of pyridinone ribonucleoside 3'-o-phosphoramidites and their incorporation into oligoribonucleotides
16. Multiple presentation of foreign peptides on the surface of an RNA-free spherical bacteriophage capsid
17. Purification, crystallization and preliminary X-ray data of the bacteriophage MS2
18. Processing of X-ray ray diffraction data collected in oscillation mode
19. The refined structure of bacteriophage MS2 at 2.8 Å resolution
20. Halloween. Masks and bones
21. Improved methods for building protein models in electron density maps and the location of errors in these model
22. Crystallography and NMR system: A new software suite for macromolecular structure determination
23. PROCHECK: A program to check the stereochemical quality of protein structures
24. Proton NMR and structural features of a 24-nucleotide RNA hairpin
25. NMR structure and dynamics of an RNA motif common to the spliceosome branch-point helix and the RNA-binding site for phage GA coat protein
26. RNA aptamers for the MS2 bacteriophage coat protein and the wild-type RNA operator have similar solution behaviour
27. Chemically modified hammerhead ribozymes with improved catalytic rates
28. Molden: A pre- and postprocessing program for molecular and electronic structures
29. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities
30. Molscript: A program to produce both detailed and schematic plots of protein structures