Characterization of the gene encoding the 100-kDa form of human 2',5'oligoadenylate synthetase

Genomics

Volumn 70, Issue 2, 2000, Pages 232-240

  Rebouillat, Dominique ^a   Hovnanian, Alain ^b   David, Gregory ^c   Hovanessian, Ara G ^d   Williams, Bryan R G ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c Unite de Recombinaison et Expression Genetique

^d INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ADENOSINE TRIPHOSPHATE; DOUBLE STRANDED RNA; INTERFERON; INTERFERON INDUCING AGENT; OLIGOMER; RETINOIC ACID;

ANTIVIRAL ACTIVITY; ARTICLE; CHROMOSOME 12; CYTOKINE PRODUCTION; EXON; GENE CLUSTER; GENETIC CODE; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN POLYMERIZATION;

EID: 0034545622     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6382     Document Type: Article

References (46)

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3. Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene
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5. A study of the interferon antiviral mechanism: Apoptosis activation by the 2-5A system
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7. Constitutive expression of (2'-5') oligo A synthetase confers resistance to picornavirus infection
8. Retinoic acid and interferon signaling cross talk in normal and RA-resistant APL cells
9. A full-length murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication
10. Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription
11. Intrinsic molecular activities of the interferon-induced 2-5A-dependent RNase
12. Transcriptional induction of the p69 isoform of 2',5'-oligoadenylate synthetase by interferon-β and interferon-γ involves three regulatory elements and interferon-stimulated gene factor 3
13. Cell growth regulatory and antiviral effects of the P69 isozyme of 2-5 (A) synthetase
14. A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon
15. Enhancement by retinoic acid and dibutyryl cyclic adenosine 3':5'-monophosphate of the differentiation and gene expression of human neuroblastoma cells induced by interferon
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18. Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells
19. The human 2',5'oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms
20. The 2-5A system: A personal view
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22. Identification of the reaction products of (2'-5')oligoadenylate synthetase in the marine sponge
23. Immunological evidence for the in vivo occurrence of (2'-5')adenylyladenosine oligonucleotides in eukaryotes and prokaryotes
24. Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase
25. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains
26. The expression of both domains of the 69/71 kDa 2',5' oligoadenylate synthetase generates a catalytically active enzyme and mediates an anti-viral response
27. Retinoic acid enhances the expression of interferon-induced proteins: Evidence for multiple mechanisms of action
28. Retinoic acid is able to induce interferon regulatory factor 1 in squamous carcinoma cells via a STAT-1 independent signalling pathway
29. The human 2',5'oligoadenylate synthetase family: Interferon-induced proteins with unique enzymatic properties
30. The 100-kDa 2',5'-oligoadenylate synthetase catalyzing preferentially the synthesis of dimeric pppA2'p5'A molecules is composed of three homologous domains
31. Interferon-induced binding of nuclear factors to promoter elements of the 2-5A synthetase gene
32. Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities
33. The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases
34. Human 2-5A synthetase: Characterization of a novel cDNA and corresponding gene structure
35. How cells respond to interferons
36. The p69/2-5A synthetase promoter contains multiple regulatory elements required for interferon-alpha-induced expression
37. Maximal induction of p69 2', 5'-oligoadenylate synthetase in Daudi cells requires cooperation between an ISRE and two IRF-1-like elements
38. Origin of the interferon-inducible (2'-5')oligoadenylate synthetases: Cloning of the (2'-5')oligoadenylate synthetase from the marine sponge Geodia cydonium
39. Isoforms p69 and p100 of 2',5'-oligoadenylate synthetase induced differentially by interferons in vivo and in vitro
40. Interferon-stimulated response element and NF kappa B sites cooperate to regulate double-stranded RNA-induced transcription of the IP-10 gene
41. Two types of chicken 2',5'-oligoadenylate synthetase mRNA derived from alleles at a single locus
42. Interferons, double-stranded RNA, and RNA degradation. Isolation and characterization of homogeneous human (2'-5')(a)n synthetase
43. Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action
44. Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L
45. Interferon action in triply deficient mice reveals the existence of alternative antiviral pathways
46. Impact of RNase L overexpression on viral and cellular growth and death