Mercuric chloride activates the Src-family protein tyrosine kinase, Hck in myelomonocytic cells

European Journal of Biochemistry

Volumn 267, Issue 24, 2000, Pages 7201-7208

  Robbins, Stephen M ^a   Quintrell, Nancy A ^b   Michael Bishop, J ^b  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmune disease; Src family kinases; Syk; Tyrosine phosphorylation

Indexed keywords

CYTOKINE; HEAVY METAL; HEMATOPOIETIC CELL KINASE; MERCURIC CHLORIDE; PROTEIN KINASE P60; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; THIOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LEUKOCYTE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TOXICOKINETICS;

BLOTTING, WESTERN; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; HUMANS; MERCURIC CHLORIDE; MONOCYTES; PRECIPITIN TESTS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-HCK; SIGNAL TRANSDUCTION;

EID: 0034533660     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01830.x     Document Type: Article

References (50)

1. Mercuric chloride-induced autoimmunity in the brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression
2. The induction of immune complex deposits in mice by peroral and parenteral administration of mercuric chloride: Strain-dependent susceptibility
3. 2 induces T and B cells to proliferate and differentiate in BN rats
4. Immune modulation by toxic metals
5. Autoimmunity and heavy metals
6. Immunoglobulin E and autoantibodies in mercury-exposed workers
7. + T cells in a responder strain
8. ++ induce cellular cytotoxicity and interferon production in murine T lymphocytes
9. Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals
10. Regulation, substrates and functions of src
11. Interaction of tyrosine kinase oncoproteins with cellular membranes
12. Myristylation and palmitylation of src family members: The fats of the matter
13. Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae
14. The when and how of Src regulation
15. Structure-function relationships in Src family and related protein tyrosine kinases
16. Crystal structure of the Src family tyrosine kinase Hck
17. Three-dimensional structure of the tyrosine kinase c-Src
18. Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement
19. Structures of Src-family tyrosine kinases
20. Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells
21. Examination of B lymphoid cell lines for membrane immunoglobulin-stimulated tyrosine phosphorylation and src-family tyrosine kinase mRNA expression
22. Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells
23. Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin
24. Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization
25. Activation of the src-related tyrosine kinases by Il-3
26. The FcγRI receptor signals through the activation of hck and MAP kinase
27. Expression of the activated (Y501F) hck tyrosine kinase in 32Dc13 myeloid cells prolongs survival in the absence of Il-3 and blocks granuloctye differentiation in response to G-CSF
28. Functional and biochemical association of Hck with the LIF/Il-6 receptor signal transducing subunit gp130 in embryonic stem cells
29. Hck expression correlates with granulocyte-macrophage colony-stimulating factor-induced proliferation in HL-60 cells
30. Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn
31. Antibody cross-linking of the glycosylphosphatidylinositol-linked protein CD59 on hematopoietic cells induces signaling pathways resembling activation by complement
32. 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration
33. A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity
34. Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect
35. The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck
36. Cbl is a downstream substrate of the Hck protein-tyrosine kinase
37. Direct evidence of the involvement of glycosylphosphatidylinositol-anchored proteins in the heavy metal-mediated signal delivery into T lymphocytes
38. Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation
39. Redox-linked ligand-independent cell surface triggering for extensive protein tyrosine phosphorylation
40. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
41. Piceatannol (3,4,3′,5′-terahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor
42. Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol
43. Mechanism of inhibition of protein-tyrosine phosphatases by disodium aurothiomalate
44. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc
45. Human protein-tyrosine kinase gene HCK: Expression and structural analysis of the promoter region
46. Receptors for insulin and epidermal growth factor: Interaction with organomercurial agarose
47. Src family protein tyrosine kinases and cellular signal transduction pathways
48. Glycoinositol phospholipid anchor-defective K562 mutants with biochemical lesions distinct from those in Thy-1-murine lymphoma mutants
49. Activation of p561ck by p72syk through physical association and N-terminal tyrosine phosphorylation
50. Regulation of the Lck SH2 domain by tyrosine phosphorylation