High-throughput screening applied to drug synthesis process development

Current Opinion in Drug Discovery and Development

Volumn 3, Issue 6, 2000, Pages 743-749

  Cannarsa, M J ^a   Uno, T ^a   Larsen, C ^a  

^a SYMYX TECHNOLOGIES   (United States)

Author keywords

Automated process development; High throughput; Medium throughput; Ten at a time

Indexed keywords

AUTOMATION; CHEMICAL REACTION; COST EFFECTIVENESS ANALYSIS; DRUG SYNTHESIS; MONITORING; PROCESS CONTROL; REACTION ANALYSIS; REVIEW; SCREENING;

EID: 0034533069     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (28)

1. Breaking the new bottleneck: Automated synthesis in chemical process research and development
2. Laboratory automation in chemical development
3. Combinatorial materials science and catalysis
4. Automated synthesis: New tools for the organic chemist
5. Using factorial experiments in the development of process chemistry
6. Advances in compatible instrumentation and software/expert systems
7. Computational components of the high throughput experimentation platform for stage I and stage II catalyst discovery
8. Selective oxidation of alcohols by combinatorial catalysis
9. High-throughput screening applied to drug synthesis process development and optimization
10. Application of automation and thermal analysis to resolving agent selection
11. Investigation of cocatalysis conditions using an automated microscale multireactor workstation: Synthesis of mesotetramesitylporphyrin
12. Improved stereoselectivity in the heterogeneous catalytic synthesis of enalapril obtained through multidimensional screening
13. A practical approach to accelerated process screening and optimization
14. Automated experimentation: Strategies to improve the quality of the acquired data
15. A versatile and cost-effective approach to automated laboratory organic synthesis
16. A brief summary of papers presented at CombiCat 1999
17. Accelerating the rate of process screening and optimization using the OptiMate Workstation(TM)
18. Rapid and efficient process parameter optimization: Statically designed experiments performed on a 12-position array
19. Breaking the new bottleneck - Our way to robotics
20. Reaping the benefits of parallel synthesis: Meeting challenges from discovery to development
21. Automated reaction development: A general synthesis of chiral 2-imidazolidinones
22. Automated process research: An extension of combinatorial principles to chemical reaction optimization
23. Automated process research. An example of accelerated optimization of the Friedel-Crafts acylation reaction, a key step for the synthesis of anti-HIV (+)-calanolide A
24. Rapid process development and scale-up using a multiple reactor system
25. Design of a robotic workstation for automated organic synthesis
26. Automated synthesis: Development of a new apparatus friendly to synthetic chemists (MEDLEY)
27. Automated synthesis: Utilization of MEDLEY in synthetic processes
28. Computer-integrated tools for batch process development