Automated synthesis: Utilization of MEDLEY in synthetic processes

Organic Process Research and Development

Volumn 4, Issue 5, 2000, Pages 337-341

  Orita, Akihiro ^a   Yasui, Yutaka ^a   Otera, Junzo ^a  

^a OKAYAMA UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034345194     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0000475     Document Type: Article

References (17)

1. Orita, A.; Yasui, Y.; Otera, J. Org. Process Res. Dev. 2000, 4, 333.
2. (a) Orita, A.; Yamashita, Y.; Toh, A.; Otera, J. Angew. Chem., Int. Ed. Engl. 1997, 36, 779.
3. (b) Orita, A.; Yoshioka, N.; Otera, J. Chem. Lett. 1997, 1023.
4. (c) Orita, A.; Watanabe, A.; Otera, J. Chem. Lett. 1997, 1025.
5. (d) Orita, A.; Watanabe, A.; Tsuchiya, H.; Otera, J. Tetrahedron 1999, 55, 2889.
6. (e) Orita, A.; Yoshicka, N.; Struwe, P.; Braier, A.; Beckmann, A.; Otera, J. Chem. Eur. J. 1999, 5, 1355.
7. (f) Orita, A.; Yaruva, J.; Otera, J. Angew. Chem. 1999, 111, 2397; Angew. Chem., Int. Ed. 1999, 38, 2267.
8. (f) Orita, A.; Yaruva, J.; Otera, J. Angew. Chem. 1999, 111, 2397; Angew. Chem., Int. Ed. 1999, 38, 2267.
9. Dubois, F.; Gingras, M. Tetrahedron Lett. 1998, 39, 5039.
10. Saito, S.; Sakai, M.; Miyaura, N. Tetrahedron Lett. 1996, 37, 2993.
11. In usual experiments, the temperature of the cooling bath, not the reaction medium itself, is measured. When the same reaction was carried out by using a normal cooling bath, without the use of the reactor for MEDLEY, the temperature of the reaction solution rose similarly.
12. For "overnight stirring problem", see ref 5 of ref 1 of this paper.
13. LeBel, N. A.; Balasubramanian N. J. Am. Chem. Soc. 1989, 111, 3363.
14. Kondo K.; Tunemoto, D. Tetrahedron Lett. 1975, 1007.
15. Alonso, F.; Lorenzo, E.; Yus, M. J. Org. Chem. 1996, 61, 6058.
16. Kuwano, R.; Uemura, T.; Saitoh, M.; Ito, Y. Tetrahedron Lett. 1999, 40, 1327.
17. Mouries, V.; Waschbuesch, R.; Carran, J.; Savignac, P. Synthesis 1998, 271.