Automated process research. An example of accelerated optimization of the Friedel-Crafts acylation reaction, a key step for the synthesis of anti-HIV (+)-calanolide A

Organic Process Research and Development

Volumn 4, Issue 6, 2000, Pages 577-580

  Zhang, Jintao ^a   Kirchhoff, Eric W ^a   Zembower, David E ^a   Jimenez, Nancy ^a   Sen, Prabir ^a   Xu, Ze Qi ^a   Flavin, Michael T ^a  

^a MediChem Research Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034345928     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op0002038     Document Type: Article

References (8)

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2. (a) Kucherenko, A.; Flavin, M. T.; Boulanger, W. A.; Khilevich, A.; Shone, R. L.; Rizzo, J. D.; Sheinkman, A. K.; Xu, Z.-Q. Tetrahedron Lett. 1995, 36, 5475.
3. (b) Flavin, M. T.; Rizzo, J. D.; Khilevich, A.; Kucherenko, A.; Sheinkman, A. K.; Vilaychack, V.; Lin, L.; Chen, W.; Greenwood, E. M.; Pengsuparp, T.; Pezzuto, J. M.; Hughes, S. H.; Flavin, T. M.; Cibulski, M.; Boulanger, W. A.; Shone, R. L.; Xu, Z.-Q. J. Med. Chem. 1996, 39, 1303.
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5. (d) Khilevich, A.; Rizzo, J. D.; Flavin, M. T.; Sheinkman, A. K.; Mar, A.; Kucherenko, A.; Yan, C.; Dzekhtser, S.; Brankovic, D.; Lin, L.; Liu, J.; Rizzo T. M.; Xu, Z.-Q. Synth. Commun. 1996, 26, 3757.
6. (a) Wagner, R. W ; Li, F.; Du, H.; Lindsey, J. S. Org. Process Res. Dev. 1999, 3, 28.
7. (b) Emiabata-Smith, D. F.; Crookes, D. L.; Owen, M. R. Org. Process Res. Dev. 1999, 3, 281.
8. Friedel-Crafts and Related Reactions; Olah, G. A., Ed.; Wiley & Sons: New York, 1973; p 313.