Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent

Phytomedicine

Volumn 7, Issue 6, 2000, Pages 529-536

  Kamimura, A ^a   Takahashi, T ^a   Watanabe, Y ^b  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

^b Wat1anabe Dermatological Clinic   (Japan)

Author keywords

Androgenetic alopecia; Condensed tannin; External application; Malus pumila; Proanthocyanidins; Scalp

Indexed keywords

PROCYANIDIN B2; PROCYANIDIN DERIVATIVE; UNCLASSIFIED DRUG;

ALOPECIA; APPLE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG SAFETY; HAIR GROWTH; HUMAN; MALE; OUTCOMES RESEARCH; PRIORITY JOURNAL; SCALP;

MALUS PUMILA; MALUS X DOMESTICA; MURINAE;

EID: 0034530385     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0944-7113(00)80040-9     Document Type: Article

References (47)

1. Antiherpesvirus activity and mode of action of SP-303, a novel plant flavonoid
2. Flavonoids as medicines (Medicaments renfermant des flavonoides)
3. Antihypertensive principles from the leaves of Melastoma candidum
4. Observations on female scalp hair population, distribution, and diameter
5. Resistance capillaire en geriatrie: Etude d'un microangioprotecteur = Endotelon
6. 13C NMR spectroscopy and determination of antifungal activities
7. Comparison of the inhibitory effects of monomeric, dimeric, and trimeric procyanidins on the biochemical markers of skin tumor promotion in mouse epidermis in vivo
8. A quantitative evaluation of hair loss: The phototrichogram
9. Natural polyphenols (vegetable tannins) as drugs: Possible modes of action
10. Transverse microscopic anatomy of the human scalp: A basis for a morphometric approach to disorders of the hair follicle
11. The inhibitory effect of tannins on lipid peroxidation of rat heart mitochondria
12. Quantitative evaluation of male pattern baldness by measurements of anagen ratio and hair shaft diameter
13. Hair diameter in female baldness
14. Characterization of inflammatory infiltrates in male pattern alopecia: Implications for pathogenesis
15. Inhibitory effects of apple polyphenol on induced histamine release from RBL-2H3 cells and rat mast cells
16. Finasteride in the treatment of men with androgenetic alopecia
17. Topical minoxidil in early androgenetic alopecia
18. Antimutagenic activity of procyanidins from Vitis vinifera
19. Inhibitory effect of polyphenol extracted from immature apples on dental plaque formation
20. Tannins related compounds. XXXVIII. Isolation and characterization of flavan-3-ol glucosides and procyanidin oligomers from cassia bark (Cinnamomum cassia Blume)
21. Development pattern of alopecia androgenetica
22. Quantitative estimation of hair growth I. Androgenetic alopecia in women: Effect of minoxidil
23. Seasonal changes in human hair growth
24. Androgenetic alopecia: Treatment results with topical minoxidil
25. The unit area trichogram in the assessment of androgen-dependent alopecia
26. Biochemical and trichological characterization of diffuse alopecia in women
27. Natural progression of male pattern baldness in young men
28. Comparative evaluation of scalp hair by phototrichogram and unit area trichogram analysis within the same subjects
29. Use of topical minoxidil in the treatment of male pattern baldness
30. Quantitative and ultrastructural analysis of inflammatory infiltrates in male pattern alopecia
31. Acquired scalp alopecia. Part I: A review
32. Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo
33. Procyanidin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo
34. Toxicological studies on procyanidin B-2 for external application as a hair growing agent
35. Alopecia androgenetica: Its incidence in Japanese and associated conditions
36. Plant proanthocyanidins. Part I. Introduction; the isolation, structure and distribution in nature of plant procyanidins
37. Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affects its rate of degradation by elastases
38. Quantitative evaluations of male pattern baldness
39. The phototrichogram: Analysis of some technical factors of variation
40. The growing hair roots of the human scalp and morphologic changes therein following amethopterin therapy
41. Geometric relationships between the matrix of the hair bulb and its dermal papilla in normal and alopecic scalp
42. Procyanidins from the roots of Fragaria vesca: Characterization and pharmacological approach
43. Anti-ulcer activity of procyanidins: Preparation of water-soluble procyanidin-cimetidine complexes
44. Procyanidins from tormentil: Fractionation and study of the anti-radical activity towards superoxide anion
45. Pycnogenol and skincare
46. Fractionation of apple procyanidins according to their degree of polymerization by normal-phase high-performance liquid chromatography
47. Cutaneous immunopathology of androgenetic alopecia