Toxicological studies on procyanidin B-2 for external application as a hair growing agent

Food and Chemical Toxicology

Volumn 37, Issue 5, 1999, Pages 545-552

  Takahashi, T ^a   Yokoo, Y ^a   Inoue, T ^a   Ishii, A ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Acute toxicity; Cosmetics; Mutagenicity; Procyanidin

Indexed keywords

PROCYANIDIN; PROCYANIDIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CHROMOSOME ABERRATION; CONTACT SENSITIZATION; CONTROLLED STUDY; DRUG SAFETY; EYE IRRITATION; GUINEA PIG; MALE; MOUSE; MUTAGENICITY; NONHUMAN; POLYPLOIDY; RABBIT; RAT; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; SUBCUTANEOUS DRUG ADMINISTRATION; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; BIFLAVONOIDS; CATECHIN; FEMALE; HAIR; HAIR PREPARATIONS; INJECTIONS, SUBCUTANEOUS; IRRITANTS; MALE; MICE; MUTAGENICITY TESTS; PROANTHOCYANIDINS; RABBITS; RATS; TOXICITY TESTS;

CAVIA PORCELLUS; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0032982631     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00044-7     Document Type: Article

References (18)

1. Brasseur T. Flavonoids as medicines (Médicaments renfermant des flavonoïdes). Journal de Pharmacie de Belgique. 44:1989;403-410.
2. Dartenuc J-Y., Marache P., Choussat H. Résistance capillaire en gériatrie étude d'un microangioprotecteur=Endotélon. Bordeaux Médical. 13:1980;903-907.
3. Draize J.H., Woodard G., Calvery H.O. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. Journal of Pharmacology and Experimental Therapeutics. 82:1944;377-390.
4. Ishidate M. Jr, Odashima S. Chromosome tests with 134 compounds on Chinese hamster cells in vitro - a screening for chemical carcinogens. Mutation Research. 48:1977;337-354.
5. Kay J.H., Calandra J.C. Interpretation of eye irritation tests. Journal of the Society of Cosmetic Chemists. 13:1962;281-289.
6. Magnusson B., Kligman A.M. The identification of contact allergens by animal assay: the guinea pig maximization test. Journal of Investigative Dermatology. 52:1969;268-276.
7. Matsuoka A., Hayashi M., Ishidate M. Jr. Chromosomal aberration tests on 29 chemicals combined with S9 mix in vitro. Mutation Research. 66:1979;277-290.
8. Morimoto S., Nonaka G., Nishioka I. Tannins and related compounds. XXXVII. Isolation and characterization of flavan-3-ol glucosides and procyanidin oligomers from cassia bark (Cinnamomum cassia Blume). Chemical and Pharmaceutical Bulletin. 34:1986;633-642.
9. Popp R., Schimmer O. Induction of sister-chromatid exchanges (SCE), polyploidy, and micronuclei by plant flavonoids in human lymphocyte cultures. A comparative study of 19 flavonoids. Mutation Research. 246:1991;205-213.
10. Porter L. J. (1994) Flavans and proanthocyanidins. In The Flavonoids: Advances in Research Since 1986, ed. J. B. Harborne, pp. 23-55. Chapman and Hall, London.
11. Schmid W. The micronucleus test. Mutation Research. 31:1975;9-15.
12. Takahashi T., Kamiya T., Yokoo Y. Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. Acta Dermato-venereologica. 78:1998;428-432.
13. Takahashi T., Kamiya T., Hasegawa A., Yokoo Y. Procyanin oligomers selectively and intensively promote proliferation of mouse hair epithelial cells in vitro and activate hair follicle growth in vivo. Journal of Investigative Dermatology. 112:1999;310-316.
14. Thompson R. S., Jacques D., Haslam E., Tanner R. J. N. (1972) Plant proanthocyanidins. Part I. Introduction; the isolation, structure and distribution in nature of plant procyanidins. Journal of the Chemical Society. Perkin Transactions 1, Organic and Bio-organic Chemistry, 1387-1399.
15. Wayne Z., Elementals L.L.C., Scottsdale A.Z. Pycnogenol and skincare. Drug and Cosmetic Industry. 158:1996;44-50.
16. Weil C.S., Scala R.A. Study of intra- and interlaboratory variability in the results of rabbit eye and skin irritation tests. Toxicology and Applied Pharmacology. 19:1971;276-360.
17. Yahagi T., Nagao M., Seino Y., Matsushima T., Sugimura T., Okada M. Mutagenicities of N-nitrosamines on Salmonella. Mutation Research. 48:1977;121-130.
18. Yu C.L., Swaminathan B. Mutagenicity of proanthocyanidins. Food and Chemical Toxicology. 25:1987;135-139.