Macrophage preconditioning with synthetic malaria pigment reduces cytokine production via heme iron-dependent oxidative stress

Laboratory Investigation

Volumn 80, Issue 12, 2000, Pages 1781-1788

  Taramelli, Donatella ^a   Recalcati, Stefania ^a   Basilico, Nicoletta ^a   Olliaro, Piero ^b   Cairo, Gaetano ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CYTOKINE; HEMATIN; HEME; HEMOZOIN; IRON; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; IMMUNOMODULATION; MALARIA; MICROGLIA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034529041     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780189     Document Type: Article

References (45)

1. Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury
2. Malarial pigment (haemozoin): A very active "inert" substance
3. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus
4. Characterization of the products of the heme detoxification pathway in malarial late trophozoites by X-ray diffraction
5. Inappropriately high iron regulatory protein reactivity in monocytes of patients with genetic homochromatosis
6. Induction of ferritin synthesis by oxidative stress: Transcriptional and posttranscriptional regulation by expansion of the "free" iron pool
7. Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione
8. The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis
9. Hemoglobin metabolism in the malaria parasite Plasmodium falciparum
10. Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver catalase
11. Iron chelation with desferrioxamine B in adults with asymptomatic Plasmodium falciparum parasitemia
12. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria
13. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
14. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
15. Hydrogen peroxide downregulates IL-1-driven mesangial iNOS activity: Implications for glomerulonephritis
16. Hematin- and peroxide-catalyzed peroxidation of phospholipid liposomes
17. High plasma levels of nitrogen oxides are associated with severe disease and correlate with rapid parasitological and clinical cure in Plasmodium falciparum malaria
18. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria
19. Translational regulation of mRNAs with distinct IRE sequences by iron regulatory proteins 1 and 2
20. Pathophysiology of fatal falciparum malaria in African children
21. Intraleucocytic malaria pigment and prognosis in severe malaria
22. Phagocytosis of hemozoin (native and synthetic malaria pigment), and Plasmodium falciparum intraerythrocyte-stage parasites by human and mouse phagocytes
23. Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by β-haematin (malaria pigment)
24. The structure of malaria pigment beta-haematin
25. Plasmodium falciparum pigment induces monocytes to release high levels of tumor necrosis factor-α and interleukin-1β
26. Heme oxygenase: Protective gene or Trojan horse
27. Heme oxygenase 1 is required for mammalian iron re-utilization
28. Reduced stress defense in heme oxygenase 1-deficient cells
29. Ultraviolet A radiation induces immediate release of iron in human primary skin fibroblasts: The role of ferritin
30. Hemozoin differentially modulates the production of interleukin 6 and tumor necrosis factor in murine malaria
31. Preferential activation of iron-regulatory protein-2 in cell lines as a result of higher sensitivity to iron
32. Response of monocyte iron regulatory protein activity to inflammation: Abnormal behavior in genetic hemochromatosis
33. Nitric oxide-mediated induction of ferritin synthesis in J774 macrophages by inflammatory cytokines: Role of selective iron regulatory protein-2 downregulation
34. The heme synthesis and degradation pathways: Role in oxidant sensitivity
35. Hemozoin stability and dormant induction of heme oxygenase in hemozoin-fed human monocytes
36. Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erytrocytes or isolated malarial pigment
37. Malaria-specific metabolite hemozoin mediates the release of several potent endogenous pyrogens (TNF, MIP1α, and MIP-1β) in vitro and altered thermoregulation in vivo
38. An ironcarboxylate bond links the heme units of malaria pigment
39. The effect of synthetic malaria pigment (beta-hematin) on adhesion molecule expression and inteleukin-6 production by human endothelial cells
40. The heme moiety of malaria pigment (β-hematin) mediates the inhibition of nitric oxide and tumor necrosis factor-α production by lipopolysaccharide-stimulated macrophages
41. Cerebrospinal fluid level of biopterin, nitric oxide metabolites, and immune activation markers and the clinical course of human cerebral malaria
42. Linkage of cell-mediated immunity to iron metabolism
43. Heme oxygenase: A novel target for the modulation of the inflammatory response
44. Stress response decreases NF-kappaB nuclear translocation and increases I-kappaBalpha expression in A549 cells
45. Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNFα