Transforming growth factor β1 (TGFβ1) mRNA level correlates with magnetic resonance imaging disease activity in multiple sclerosis patients

Neuroscience Letters

Volumn 263, Issue 1, 1999, Pages 21-24

  Bertolotto, Antonio ^a   Capobianco, Marco ^a   Malucchi, Simona ^a   Elsa Manzardo, ^a   Audano, Luisa ^a   Bergui, Mauro ^b   Bradac, Gianni Boris ^b   Mutani, Roberto ^a  

^a Div Univ Neurol Osp S L   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

Author keywords

Disease activity; Immunological markers; Magnetic resonance imaging; mRNA; Multiple sclerosis; Transforming growth factor 1

Indexed keywords

MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; CLINICAL ARTICLE; DISEASE ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

ADULT; BRAIN; FEMALE; GADOLINIUM DTPA; HUMANS; LEUKOCYTES, MONONUCLEAR; MAGNETIC RESONANCE IMAGING; MALE; MULTIPLE SCLEROSIS; RECURRENCE; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033582971     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00102-0     Document Type: Article

References (18)

1. Bansil S., Cook S.D., Rohowsky-Kochan C. Multiple Sclerosis: immune mechanism and update on current therapies. Ann. Neurol. 37(1):1995;S87-S101.
2. Barkhof F., Hommes O.R., Scheltens P., Valk J. Quantitative MRI changes in gadolinium-DTPA enhancement after high-dose intravenous methylprednisolone in multiple sclerosis. Neurology. 41:1991;1219-1222.
3. Barnard J.A., Lyons R.M., Moges H.L. The cell biology of transforming growth factor beta. Biochim. Biophys. Acta. 1032:1990;79-87.
4. Carrieri P.B., Provitera V., Bruno R., Perrella M., Tartaglia G., Busto A., Perrella O. Possible role of transforming growth factor-beta in relapsing-remitting multiple sclerosis. Neurol. Res. 19:1997;599-600.
5. Celi F.S., Zenilman M.E., Shuldiner R.A. A rapid and versatile method to synthesize internal standard for competitive PCR. Nucleic Acids Res. 21:1993;1047.
6. Correale J., Gilmore W., McMillan M., Simon L., McCarthy K., Thuy L., Weiner L.P. Patterns of cytokine secretion by autoreactive proteolipid protein-specific T cell clones during the course of multiple sclerosis. J. Immunol. 154:1995;2959-2968.
7. Hartung H.P., Archelos J.J., Zielasek J., Gold R., Koltzenburg M., Reiners K.H., Toyka K.V. Circulating adhesion molecules and cytokines in inflammatory demyelination: a review. Neurology. 45(S6):1995;S22-S32.
8. Link J., Soderstrom M., Olsson T., Hojeberg B., Ljungdahl A., Link H. Increased transforming growth factor-β, interleukin-4 and interferon-β in Multiple Sclerosis. Ann. Neurol. 36:1994;379-386.
9. Martino G.V., Consiglio A., Franciotta D.M., Corti A., Filippi M. Tumor necrosis factor β and its receptors in relapsing-remitting multiple sclerosis. J. Neurol. Sci. 152:1997;51-61.
10. Mokhtarian F., Shi Y., Shirazian D., Morgante L., Miller A., Grob D. Defective production of anti-inflammatory cytokine, TGF-β by T cell lines of patients with active multiple sclerosis. J. Immunol. 152:1994;6003-6010.
11. Ossege L.M., Sindern E., Voss B., Malin J.P. Corticosteroids induce expression of transforming-growth-factor-beta1 mRNA in peripheral blood mononuclear cells of patients with multiple sclerosis. J. Neuroimmunol. 84:1998;1-6.
12. Poser C.M., Paty D.W., Scheinberg L., McDonald W.I., Davis F.A., Ehers G.C., Johnson K.P., Sibley W.A., Silberberg D.H., Tourtellotte W.W. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann. Neurol. 13:1983;227-231.
13. Raeymaekers L. Quantitative PCR: theoretical considerations with practical implications. Anal. Biochem. 214:1993;582-585.
14. Rieckmann P., Albrecht M., Kitze B., Weber T., Tumani H., Broocks A., Luer W., Poser S. Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis. Neurology. 44:1994;1523-1526.
15. Rieckmann P., Albrecht M., Kitze B., Weber T., Tumani H., Broocks A., Luer W., Helwig A., Poser S. Tumor necrosis factor-β messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann. Neurol. 37:1995;82-88.
16. Schumacher G.A., Beebe G., Kubler R.F., Kurland L.T., Kurtzke J.F., McDowell F., Nagler B., Sibley W.A., Tourtellotte W.W., Willmon T.L. Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann. N.Y. Acad. Sci. 122:1965;522-568.
17. Stone, L.A., McFarland, H.F. and Frank, J.A., Neuroimaging in Multiple Sclerosis. In S.D. Cook (Ed.), Handbook of Multiple Sclerosis, Marcel Dekker, New York, 1996, pp. 347-376.
18. Wahl S.M. Transforming growth factor β: the good, the bad and the ugly. J. Exp. Med. 180:1994;1587-1590.