Resistance to CD95-mediated apoptosis through constitutive c-FLIP expression in a non-Hodgkin's lymphoma B cell line

Leukemia

Volumn 14, Issue 12, 2000, Pages 2149-2158

  Irisarri, M ^a   Plumas, J ^a   Bonnefoix, T ^a   Jacob, M C ^a   Roucard, C ^a   Pasquier, M A ^a   Sotto, J J ^a   Lajmanovich, A ^a  

^a INSTITUT ALBERT BONNIOT   (France)

Author keywords

Apoptosis; C FLIP; CD95; Lymphoma

Indexed keywords

APOPTOSIS INHIBITOR; CASPASE 3; CASPASE 8; CD19 ANTIGEN; CD20 ANTIGEN; CD23 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; CYCLOHEXIMIDE; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; STAUROSPORINE;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DEATH; CELL STIMULATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LYMPHOID CELL LINE; LYMPHOMA CELL LINE; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION;

EID: 0034525562     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401954     Document Type: Article

References (60)

1. The Fas death factor
2. Mechanisms and genes of cellular suicide
3. Monoclonal antibody-mediated tumor regression by induction of apoptosis
4. A cell killing monoclonal anti-body (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
5. The CD95 system and the death of a lymphocyte
6. Cytolytic T cell cytotoxicity is mediated through perforin and Fas lytic pathways
7. Fas and perforin pathways as major mechanisms of T cell mediated cytotoxicity
8. T cell commit suicide, but B cells are murdered
9. Mutation in Fas associated with human lymphoproliferative syndrome and autoimmunity
10. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproloferative syndrome
11. Expansion or elimination of B cells in vivo: Dual roles for CD40 and Fas (CD95) ligands modulated by the B cell antigen receptor
12. Frequent expression of Fas/APO-1 in Hodgkin's disease and anaplastic large cell lymphomas
13. Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease
14. High expression of APO-1 (CD95) on T-lymphocytes from HIV infected children
15. A revised European-American classification of lymphoid neoplasmes: A proposal from the International Lymphoma Study Group
16. Tumor B cells from non-Hodgkin's lymphoma are resistant to CD95 (Fas/APO-1)-mediated apoptosis
17. Advances in apoptosis research
18. Caspases killer proteases
19. Death receptor: Signaling and modulation
20. CD95 (APO1/Fas)-associating signaling proteins
21. An induced proximity model for caspase-8 activation
22. Mch3, a novel human apoptotic cysteine protease highly related to CPP32
23. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
24. Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8
25. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase
26. Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death
27. Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
28. Apoptosis in the pathogenesis and treatment of disease
29. Molecular thanatopsis: A discourse on the Bcl-2 family and cell death
30. Mitochondrial control of apoptosis
31. Two CD95 (APO-1/Fas) signaling pathways
32. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex
33. Inhibition of death receptor signals by cellular FLIP
34. CASH, a novel caspase homologue with death effector domains
35. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
36. FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation
37. The IgG Fc receptor, Fc γ RIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma
38. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V
39. Isolation and analysis of components of CD95 (APO-1/Fas) death-inducing signalling complex
40. Expression and function of CD95 (Fas/APO-1) in leukaemia-lymphoma tumor lines
41. Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation
42. Inverse expression of Bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes
43. Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood
44. Fas ligation induces apoptosis of CD40-activated human B lymphocytes
45. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway
46. The role of c-FLIP in modulation of CD95-induces apoptosis
47. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
48. Molecular ordering of the cell death pathway: Bcl-2 and Bcl-xL function upstream of the ced-3 like apoptotic proteases
49. Bcl-2, Bcl-xL and adenovirus protein E1B19 kD are functionally equivalent in their ability to inhibit cell death
50. Fas-induced activation of cell death-related protease CPP32 is inhibited by Bcl-2 and by ICE family protease inhibitors
51. Bcl-xL can inhibit apoptosis in cells that have undergone Fas-induced proteases activation
52. Bcl-xL acts down-stream of caspase-8 activation by the CD95 death-inducing signaling complex
53. Bcl-x protects primary B cells against Fas-mediated apoptosis
54. Bruton's tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex
55. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
56. A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors
57. CD95 receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas mediated apoptosis
58. Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells
59. Search for rearrangements and/or allelic loss of the Fas/APO-1 gene in 101 human lymphomas
60. NMR structure and mutagenesis of the FADD (Mort 1) death-effector domain