Chemical biology beyond binary codes

Chemistry and Biology

Volumn 7, Issue 12, 2000, Pages

  Michnick, S W ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Controlled therapeutic delivery; FKBP12; Immunophilin protein; Macromolecular assembler

Indexed keywords

FK 506 BINDING PROTEIN; TACROLIMUS;

ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; GENETICS; MACROMOLECULE; METABOLISM; MUTATION; PROTEIN BINDING; SECRETION; SHORT SURVEY; SIGNAL TRANSDUCTION;

ANIMALS; DIMERIZATION; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; TACROLIMUS; TACROLIMUS BINDING PROTEIN 1A;

ANIMALIA;

EID: 0034524746     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00040-5     Document Type: Short Survey

References (23)

1. A ligand-reversible dimerization system for controlling protein-protein interactions
2. Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum
3. A mammalian protein targeted by G1-arresting rapamycin-receptor complex
4. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
5. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
6. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
7. Rational design of orthogonal receptor-ligand combinations
8. Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins
9. Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization
10. Controlling signal transduction with synthetic ligands
11. Functional analysis of fas signaling in vivo using synthetic inducers of dimerization
12. Three-part inventions: Intracellular signaling and induced proximity
13. Regulated gene expression systems
14. Multienzyme complexes
15. Self-assembly of biological macromolecules
16. Protein-protein interactions define specificity in signal transduction
17. A novel genetic system to detect protein-protein interactions
18. The two-hybrid system: A method to identify and clone genes for proteins that interact with a protein of interest
19. Understanding, improving and using green fluorescent proteins
20. Fluorescence ratio imaging of cyclic AMP in single cells
21. Clonal selection and in vivo quantitation of protein interactions with protein fragment complementation assays
22. Erythropoietin receptor activation by a ligand-induced conformation change
23. Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity