Hydrogen peroxide - An intracellular signal in the pulmonary circulation: Involvement in hypoxic pulmonary vasoconstriction

Pharmacology and Therapeutics

Volumn 88, Issue 2, 2000, Pages 153-161

  Jones, R D ^a,b   Morice, A H ^a  

^a UNIVERSITY OF HULL   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Hydrogen peroxide; Hypoxic pulmonary vasoconstriction; Pulmonary circulation; Redox potential; Vasoconstriction; Vasodilation

Indexed keywords

HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ARTICLE; BLOOD VESSEL REACTIVITY; HYPOXIA; HYPOXIC LUNG VASOCONSTRICTION; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG DISEASE; LUNG PERFUSION; LUNG VENTILATION; OXIDATION REDUCTION POTENTIAL; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY CHAIN;

EID: 0034522682     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(00)00089-9     Document Type: Review

References (68)

1. Potentiation of the hypoxic contraction of guinea pig isolated pulmonary arteries by two inhibitors of superoxide dismutase
2. Hydrogen peroxide stimulates mitogen activated protein kinase in bovine tracheal myocytes: Implications for human airway disease
3. Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischaemia or high potassium
4. Hypoxic pulmonary vasoconstriction is unaltered by creatine depletion induced by dietary beta-guanidine propionic acid
5. 2 sensor in the rat pulmonary vasculature
6. t-Butyl hydrogen peroxide and glutathione modulate an outward potassium current in rat pulmonary vascular smooth muscle cells
7. Dithionate increases radical formation and decreases vasoconstriction in the lung: Evidence that dithionate does not mimic alveolar hypoxia
8. Oxygen sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase
9. Biphasic contractile response of pulmonary artery to hypoxia
10. Energy state and vasomotor tone in hypoxic pig lungs
11. Hydrogen peroxide induced pulmonary vasoconstriction in isolated rat lungs is attenuated by U60,257, a leucotriene synthesis blocker
12. Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation
13. Hydrogen peroxide and cGMP may function as an oxygen sensor in the pulmonary artery
14. Hydrogen peroxide induced pulmonary vasodilation: Role of guanosine 3′,5′-cyclic monophosphate
15. Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria
16. 2 in pulmonary vascular smooth muscle cells
17. 2 in rabbit pulmonary arterial smooth muscle cells
18. 2 in rabbit pulmonary arterial smooth muscle cells
19. 2 and PCO
20. Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria
21. Biology of disease: Free radicals and tissue injury
22. Effects of NADPH oxidase inhibitors on hypoxic vasoconstriction in buffer-perfused rabbit lungs
23. Activation of tyrosine kinases in hydrogen peroxide-induced contraction in pulmonary artery
24. Reactive oxygen mediated contraction in pulmonary arterial smooth muscle: Cellular mechanisms
25. Cadmium and zinc sulphate - Antagonists of the NADPH oxidase-associated proton channel inhibit hypoxic pulmonary vasoconstriction
26. 2α and potassium chloride induced contractions in isolated rat pulmonary arteries
27. Iodonium diphenyl inhibits hypoxic pulmonary vasoconstriction in isolated pulmonary arteries
28. Toxic oxygen metabolites induce vasoconstriction and bronchoconstriction in isolated, plasma perfused rat lungs
29. Lucigenin (bis-N-methylacridinium) as a mediator of superoxide anion production
30. Lucigenin as a mediator of superoxide anion production: Revisited
31. Pulmonary vasoconstriction during histotoxic hypoxia
32. Graded effects of oxygen and respiratory inhibitors on cell metabolism and spontaneous contractions in smooth muscle of the rat portal vein
33. Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction
34. Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle
35. 2 sensor
36. 2-induced activation of endothelial cell phospholipase D
37. The biochemical, pathophysiological and medical aspects of ubiquinone function
38. Modulation of the calcium channel voltage sensor and excitation-contraction coupling by silver
39. Redox agents as a link between hypoxia and the responses of ionic channels in rabbit pulmonary vascular smooth muscle
40. + channels by the intracellular redox potential in pulmonary and ear arterial smooth muscle cells of the rabbit
41. Redox regulation of potassium channels and hypoxic pulmonary vasoconstriction
42. Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by DPI
43. Opposing effects of oxidants and antioxidants on potassium channel activity and tone in rat vascular tissue
44. Reactive oxygen species alter contractile properties of pulmonary arterial smooth muscle
45. Inhibitors of oxidative ATP production cause transient contraction and block subsequent pressor responses in rat lungs
46. K(A) channels by cysteine oxidation
47. 2+ signals
48. 2+ channels in skeletal, cardiac and smooth muscles
49. The glutathione redox cycle as a defence system against hydrogen peroxide induced prostanoid formation and vasoconstriction in rabbit lungs
50. Characterisation and mechanisms of hydrogen peroxide induced contractions of pulmonary arteries
51. Inhibition of macrophage and endothelial cell NO synthase by DPI and its analogues
52. Oxygen-radical-mediated permeability oedema and vasoconstriction in isolated perfused rabbit lungs
53. Inhibition of hypoxic pulmonary vasoconstriction by diphenelyeneiodonium
54. Inhibition of hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries by diphenyleneiodonium
55. The role of tyrosine kinase in hypoxic contraction of sheep pulmonary artery rings
56. Inhibitory actions of DPI on endothelial-dependent vasodilatations in vitro and in vivo
57. Hydrogen peroxide acts as a second messenger in hypoxia-induced pulmonary vasoconstriction
58. Mitochondrial reactive oxygen species are involved in hypoxic pulmonary vasoconstriction
59. The mechanism of acute hypoxic pulmonary vasoconstriction: The tale of two channels
60. Redox status and pulmonary vascular reactivity
61. 2+ currents in isolated pulmonary artery smooth muscle cells
62. Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction
63. Sub-lethal levels of oxidant stress stimulate multiple serine/threonine kinases and suppress protein phosphatases in Jurkat T cells
64. 2 pulmonary vasoconstriction
65. Constriction and dilatation of pulmonary arterial ring by hydrogen peroxide - Importance of prostanoids
66. Deoxyglucose and reduced glutathione mimic effects of hypoxia on potassium and calcium conductance in pulmonary artery cells
67. Acute hypoxic pulmonary vasoconstriction in isolated rat small and large pulmonary arteries
68. Hydrogen peroxide stimulates extracellular signal-regulated protein kinases in pulmonary artery smooth muscle cells