Very strong correlation between dominant negative activities of mutant thyroid hormone receptors and their binding avidity for corepressor SMRT

Journal of Endocrinology

Volumn 167, Issue 3, 2000, Pages 493-503

  Matsushita, A ^a   Misawa, H ^a   Andoh, S ^a   Natsume, H ^a   Nishiyama, K ^a   Sasaki, S ^a   Nakamura, H ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOID X RECEPTOR; SILENCING MEDIATOR FOR RETINOID AND THYROID HORMONE RECEPTOR; THYROID HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSCRIPTION; LIGAND BINDING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REPORTER GENE; THYROID HORMONE RESISTANCE;

ANALYSIS OF VARIANCE; BINDING, COMPETITIVE; DNA-BINDING PROTEINS; GENES, DOMINANT; HUMANS; MUTATION; NUCLEAR PROTEINS; PROTEIN BINDING; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS;

EID: 0034522171     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1670493     Document Type: Article

References (34)

1. Introducing a point mutation identified in a patient with pituitary resistance to thyroid hormone (Arg 338 to Trp) into other mutant thyroid hormone receptors weakens their dominant negative activities
2. Cell-specific inhibition of retinoic acid receptor-alpha silencing by the AF2/tau c activation domain can be overcome by the corepressor SMRT, but not by N-CoR
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14. Two consecutive nucleotide substitutions resulting in the T3 receptor beta gene resulting in an 11-amino acid truncation in a patient with generalized resistance to thyroid hormone
15. Comparison of the functional properties of three different truncatedthyroid hormone receptors identified in subjects with resistance to thyroid hormone
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18. Requirement of corepressor binding of thyroid hormone receptor mutants for dominant negative inhibition
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21. A rapid, sensitive, and inexpensive assay for chloramphenicol acetyltransferase
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34. Differential recognition of liganded and unliganded thyroid hormone receptor by retinoid X receptor regulates transcriptional repression