LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice

Journal of Lipid Research

Volumn 41, Issue 12, 2000, Pages 2055-2062

  Tacken, P J ^a   Teusink, B ^a   Jong, M C ^a   Harats, D ^a   Havekes, L M ^a   Van Dijk, K W ^a   Hofker, M H ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Fatty acids; Lipid metabolism; Lipoprotein receptor

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FATTY ACID TRANSPORT; KNOCKOUT MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; DNA PRIMERS; FEMALE; LIPOPROTEINS, VLDL; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, LDL; TRIGLYCERIDES;

EID: 0034521695     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Rabbit very low density lipoprotein receptor: A low density lipoprotein receptor-like protein with distinct ligand specificity
2. Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene
3. Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase
4. The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor
5. The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes
6. Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
7. Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry
8. Dietary regulation of the very low density lipoprotein receptor in mouse heart and fat
9. Mouse very low-density lipoprotein receptor (VLDLR): Gene structure, tissue-specific expression and dietary and developmental regulation
10. Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor
11. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
12. Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter
13. Human very-low-density lipoprotein receptor complementary DNA and deduced amino acid sequence and localization of its gene (VLDLR) to chromosome band 9p24 by fluorescence in situ hybridization
14. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphatedehydrogenase multigenic family
15. Expression of the VLDL receptor in endothelial cells
16. Effect of bone marrow transplantation on lipoprotein metabolism and atherosclerosis in LDL receptor-knockout mice
17. Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles
18. Isopropanol precipitation method for the determination of apolipoprotein B specific activity and plasma concentrations during metabolic studies of very low density lipoprotein and low density lipoprotein apolipoprotein B
19. Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix
20. Heparan sulphate proteoglycans are involved in the lipoprotein lipase-mediated enhancement of the cellular binding of very low density and low density lipoproteins
21. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor
22. Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1
23. Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
24. In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway
25. An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins