Molecular mechanisms of differentiation and death of human neurons: With special reference to necdin and APP

Japanese Journal of Psychopharmacology

Volumn 20, Issue 4, 2000, Pages 155-159

  Yoshikawa, K ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Genomic imprinting; Human neurons; Postmitotic cells

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CASPASE 3; NECDIN; ONCOPROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; ASSOCIATION CORTEX; BRAIN STEM; CELL PROLIFERATION; CHROMOSOME 15Q; DEGENERATIVE DISEASE; EMBRYONAL CARCINOMA; ENZYME ACTIVATION; GENE TRANSFER; GENOME IMPRINTING; HYPOTHALAMUS; MITOSIS; MITOSIS INHIBITION; NERVE CELL DIFFERENTIATION; PHYLOGENY; PRADER WILLI SYNDROME; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SHORT SURVEY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; APOPTOSIS; CASPASE 3; CASPASES; CELL DIFFERENTIATION; GENOMIC IMPRINTING; HUMANS; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; PRADER-WILLI SYNDROME;

EID: 0034521646     PISSN: 13402544     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (29)

1. Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain
2. Regulation and deregulation of E2F1 in postmitotic neurons differentiated from embryonal carcinoma P19 cells
3. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons
4. The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region
5. Disruption of the mouse necdin gene results in early post-natal lethality
6. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic A beta peptide formation
7. Arrest of cell growth by necdin, a nuclear protein expressed in postmitotic neurons
8. The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region
9. Determination of a necdin cis-acting element required for neuron specific expression by using zebra fish
10. The necdin gene is deleted in Prader-Willi syndrome and is imprinted in human and mouse
11. Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor
12. A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells
13. The human chromosomal gene for necdin, a neuronal growth suppressor, in the Prader-Willi syndrome deletion region
14. Characterization and chromosomal mapping of a human necdin pseudogene
15. Cellular and subcellular localization of necdin in fetal and adult mouse brain
16. Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer
17. Cell death during development of the nervous system
18. Neuronally-expressed necdin gene: An imprinted candidate gene in Prader- Willi syndrome
19. Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1
20. Physical and functional interactions of neuronal growth suppressor necdin with p53
21. Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoter
22. Activation of neuronal caspase-3 by intracellular accumulation of wild- type Alzheimer amyloid precursor protein
23. Evidence for p53-mediated modulation of neuronal viability
24. Neurotoxicity of β amyloid (Scientific Correspondence)
25. Neurotoxicity of amyloid β-protein and the amyloid β-protein precursor
26. Internal disintegration of neurons by amyloid β protein precursors
27. Cell cycle regulators in neural stem cells and postmitotic neurons
28. Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells
29. Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor