Differential toxicities of TCDD in vivo among normal, c-src knockout, geldanamycin- and quercetin-treated mice

Toxicology

Volumn 135, Issue 2-3, 1999, Pages 95-107

  Dunlap, Debra Y ^a   Moreno Aliaga, Maria J ^a   Wu, Zhong ^a   Matsumura, Fumio ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; c src Knockout mice; Differential toxicity; Liver triglyceride accumulation

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; GELDANAMYCIN; PROTEIN TYROSINE KINASE INHIBITOR; QUERCETIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; HISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; LIVER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING;

ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMALS; BENZOQUINONES; ENVIRONMENTAL POLLUTANTS; ENZYME INHIBITORS; LACTAMS, MACROCYCLIC; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICROSOMES, LIVER; ORGAN SIZE; PROTEIN-TYROSINE KINASES; QUERCETIN; QUINONES; RADIOLIGAND ASSAY; SPECIES SPECIFICITY; SRC-FAMILY KINASES; TETRACHLORODIBENZODIOXIN; THYMUS GLAND; TRIGLYCERIDES; WEIGHT GAIN;

EID: 0032784238     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(99)00054-2     Document Type: Article

References (24)

1. Aiyer R.A., Aggrawal B.B. Characterization of receptors for recombinant human tumor necrosis factor α from human placental membranes. Lymphokine Res. 9:1990;333-344.
2. Ashida H., Matsumura F. Effect of in vivo administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on DNA binding activities of nuclear transcription factors in liver of guinea pigs. J. Biochem. Mol. Toxicol. 12:1998;191-204.
3. Block G.D., Locker J., Bowen W.C. et al. Population expansion, clonal growth and specific differentiation patterns in primary cultures of hepatocytes induced by HGF/SF, EGF and TGF2 in a chemically defined (HGM) medium. J. Cell Biol. 132:1996;1133-1149.
4. Bock K.W. Aryl hydrocarbon or dioxin receptor: biologic and toxic responses. Rev. Physiol. Biochem. Pharmacol. 125:1994;1-42.
5. Butler W.M. Jr., Maling H.M., Herning M.G., Brodie B.B. The direct determination of liver triglycerides. J. Lipid Res. 2:1961;95-96.
6. Dignam I.D., Lebovitz R.M., Roeder R.A. Accurate transcription initiation by RNA polymerase II in a soluable extract from isolated mammalian nuclei. Nucleic Acid Res. 11:1983;1475-1489.
7. Diliberto J.J., Burgin D., Birnbaum L.S. Role of CYPIA2 in hepatic sequestration of dioxin: studies using CYPIA2 knock-out mice. Biochem. Biophys. Res. Commun. 236:1997;431-433.
8. Enan E., Matsumura F. Identification of c-Src as the intergral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway. Biochem. Pharmacol. 52:1996;1599-1612.
9. Fisher J.M., Jones K.W., Whitlock J.P. Activation of transcription as a general mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Mol. Carcinog. 1:1989;216-221.
10. Herschman H.R. Primary response genes induced by growth factors and tumor promoters. Annu. Rev. Biochem. 60:1991;281-319.
11. Hustad C.M., Perry W.L., Syracusa L.D. et al. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus. Genetics. 140:1995;255-265.
12. Liu P.C.C., Dunlap D.Y., Matsumura F. Suppression of C/EBPα and induction of C/EBPβ by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mouse adipose tissue and liver. Biochem. Pharmacol. 55:1998;1647-1655.
13. Ma X., Babish J.G. Acute 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure results in enhanced tryosylphosphorylation and expression of murine hepatic cyclin dependent kineses. Biochem. Biophys. Res. Commun. 197:1993;1070-1077.
14. Madhukar B.V., Brewster D.W., Matsumura F. Effects of in vivo administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse and hamster. Proc. Natl. Acad. Sci. USA. 81:1984;7407-7411.
15. Matsumura F. How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemical? Biochem. Pharmacol. 48:1994;215-224.
16. Matsumura F., Enan E., Dunlap D.Y., Pinkerton K.E., Peake J. Altered in vivo toxic expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Src-deficient mice. Biochem. Pharmacol. 53:1997;1397-1404.
17. Parson T. Protein modules and signalling network. Nature. 373:1995;573-580.
18. Petrescu I., Bojan O., Saied M., Barzu O., Schnmidt F., Kuehnle H.F. Determination of phosphoenolpyruvate carboxykinase activity with deoxyguanosine 5′-diphosphate as nucleotide substrate. Anal. Biochem. 96:1979;279-281.
19. Poland A., Kende A. The genetic expression of aryl hydrocarbon hydroxylase activity: evidence of a receptor mutation in nonresponsive mice. Hiatt H.H., Watson S.D., Winsten J.A. Origins of Human Cancer. 1977;847-867 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
20. Poland A., Kuntson J.C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examinations of the mechanisms of toxicity. Ann. Rev. Pharmacol. Toxicol. 22:1982;517-554.
21. Poland A., Kimbrough R.D. Biological Mechanisms of Dioxin Action, Banbury Report 18. 1984;500 Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
22. Rana B., Mischoulon D., Xie Y., Bucher N.L.R., Farmer S.R. Cell-extra cellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBPα and immediate-early growth response transcription factors. Mol. Cell. Biol. 14:1994;5858-5869.
23. Silbergeld E.K., Gasiewics T.A. Dioxins and the Ah receptor. Am. J. Ind. Med. 16:1989;455-474.
24. Soriano P., Montgomery C., Geske R., Bradley A. Targeted disruption of the c-Src proto-oncogene leads to osteoporosis in mice. Cell. 64:1991;693-702.