“Thanatosomes”: A unifying morphogenetic concept for tumor hyaline globules related to apoptosis

Human Pathology

Volumn 31, Issue 12, 2000, Pages 1455-1465

  Papadimitriou, John C ^a   Drachenberg, Cinthia B ^a   Brenner, David S ^a   Newkirk, Carnell ^a   Trump, Benjamin F ^a   Silverberg, Steven G ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Cell blebbing; Cell membrane permeability; Cellular turnover; Serum proteins

Indexed keywords

COLLAGEN; PLASMA PROTEIN;

APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL TYPE; CELL ULTRASTRUCTURE; CHROMATIN CONDENSATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MORPHOGENESIS; PROTEIN LOCALIZATION; TUMOR GROWTH; TUMOR LOCALIZATION;

EID: 0034521519     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2000.20376     Document Type: Article

References (90)

1. Cytoplasmic hyaline inclusions in hepatoma: Histochemical study
2. Certain cytoplasmic inclusions of liver cells
3. Cytoplasmic liver cell inclusions following arterialization in the dog
4. Intracytoplasmic periodic acid-Schiff-positive nonglycogenic globules in canine liver: Their histochemical characterization
5. Alpha-antitrypsin deposition in primary hepatic carcinomas
6. Hyaline globules of the adrenal medulla of man: A product of lipid peroxidation
7. Hyaline globules of the adrenal medulla
8. Hyaline globules in human neoplasms: A report of three autopsy cases
9. Hyaline intracytoplasmic globules in renal carcinoma
10. Intracellular hyaline globules in carcinoma kidney: Histologic and ultrastructural observation
11. Hyaline globules
12. Alpha-1-antitrypsin: Its immunohistochemical localization and significance in diagnostic pathology
13. Ovarian malignant mixed mesodermal tumor: The occurrence of hyaline droplets containing alpha 1-antitrypsin
14. Alpha1-antitrypsin and alpha-fetoprotein: Protein markers in endodermal sinus (yolk sac) tumors
15. Alpha-1-antitrypsin in a malignant mixed mesodermal tumor of the ovary
16. Hepatoid adenocarcinoma of the stomach: Case report and review of the literature
17. Immunofluorescent demonstration of alpha-fetoprotein and other plasma proteins in yolk sac tumor
18. Hepatic hyaline globules associated with passive congestion
19. Hyaline globules in Kaposi's sarcoma: A light microscopic and immunohistochemical study
20. Eosinophilic intracytoplasmic globules in pulmonary adenocarcinomas: A histochemical, immunohistochemical, and ultrastructural study of six cases
21. Gonadal and related neoplasms
22. Yolk sac tumors of the testis
23. Atlas of the gross and microscopic features
24. The nature of hyaline (eosinophilic) globules and vascular slits of Kaposi's sarcoma
25. The nature of hyaline globules in adenocarcinoma of the lung
26. Specific proteins
27. Ultrastructural analysis of asteroid bodies: Evidence for membrane lipid bilayer nature of components
28. Erythrophagocytosis by undifferentiated lung carcinoma cells
29. Erythrophagocytosis by epithelial cells of a breast carcinoma
30. Globular Mallory like bodies in renal cell carcinoma: Report of a case and review of cytoplasmic eosinophilic globules
31. Pathology of the cell: Ultrastructural features
32. Protein changes associated with ionizing radiation-induced apoptosis in human prostate epithelial tumor cells
33. Endoplasmic reticulum-associated protein degradation
34. Apoptosis, oncosis, and necrosis: An overview of cell death
35. Apoptosis
36. Redefining cell death
37. Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action
38. Immunohistochemical characterization of extracellular matrix components of yolk sac tumors
39. Demonstration of fibrils in the hyaline globules of yolk sac tumor with parietal differentiation in fine-needle aspiration smears
40. Glassy hyaline globules in granular cell carcinoma, chromophobe cell carcinoma and oncocytoma of the kidney
41. Immunocytochemical diagnosis of alpha-1-antitrypsin deficiency
42. Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma
43. Fibrolamellar hepatocellular carcinoma: An immunohistochemical and ultrastructural study
44. Undifferentiated (embryonal) sarcoma of the liver: Report of 31 cases
45. Undifferentiated (embryonal) sarcoma of the liver with alpha-1-antitrypsin deposits: Immunohistochemical and ultrastructural studies
46. Alpha1-antitrypsin, protein marker in oral contraceptive-associated hepatic tumors
47. Hyaline globules in yolk sac tumor: Histochemical, immunohistochemical and electron microscopic studies
48. Yolk sac differentiation in germ cell tumors: A morphologic study of 50 cases with emphasis on hepatic, enteric, and parietal yolk sac features
49. Hepatoid yolk sac tumors of the mediastinum: A clinicopathologic and immunohistochemical study of four cases
50. Hepatoid carcinoma of the ovary: A case report
51. Signet-ring stromal and related tumors of the ovary
52. Hyaline globules and progesterone receptors in an ovarian sclerosing stromal tumour
53. Small cell carcinoma of the ovary, hypercalcemic type: A clinicopathological analysis of 150 cases
54. The tubular variant of adenoid cystic carcinoma of the Bartholin's gland
55. Spindle cell epithelioma, the so-called mixed tumor of the vagina: A clinicopathologic, immunohistochemical, and ultrastructural analysis of 28 cases
56. Malignant paraganglioma of the uterus
57. A human vitelline component in embryonal carcinoma of the testis
58. Clear cell (mesonephroid) tumors of the ovary with characteristics resembling endodermal sinus tumor
59. Intramural papilloma of the vagina. Evidence of Muellerian histogenesis
60. Cystic transformation of the rete testis
61. Rete testis hyperplasia with hyaline globule formation: A lesion simulating yolk sac tumor
62. Adrenal medullary hyperplasia and pheochromocytoma
63. Adrenal cortical neoplasms
64. Adrenal cortical neoplasms in the pediatric and adolescent age group. Clinicopathologic study of 30 cases with emphasis on epidemiological and prognostic factors
65. Pulmonary blastoma: An ultrastructural and histochemical study
66. A comparison of different methods of detecting mucin in adenocarcinomas of the lung
67. Hepatoid adenocarcinoma of the lung: Report of a case of an unusual alpha-fetoprotein-producing lung tumor
68. Ductal adenoma of the breast: The cytological features of six cases
69. Solid and papillary epithelial neoplasm of the pancreas: An ultrastructural and immunocytochemical study of six cases
70. Papillary adenocarcinoma of the sigmoid colon associated with psammoma bodies and hyaline globules: Report of a case
71. Fine needle aspiration of pleomorphic adenoma and adenoid cystic carcinoma of salivary gland origin
72. Hyaline globules in renal cell carcinomas and oncocytomas
73. Hepatoid adenocarcinoma in the urinary bladder: Unusual localization of a newly recognized tumor type
74. Atypical basal cell hyperplasia of the prostate
75. Multilocular peritoneal inclusion cyst (multicystic mesothelioma) with hyaline globules
76. Fibronectin-containing hyaline globules in malignant melanoma
77. Demonstration of secretory component, IgA, and IgM by the peroxidase-antiperoxidase technique in inverted papillomas of the nasal cavities
78. Liposarcoma: A study of 103 cases
79. Intracytoplasmic eosinophilic hyaline globules in cartilaginous neoplasms: A surgical, pathological, ultrastructural, and electron probe x-ray microanalytic study
80. Embryonal form of extraskeletal myxoid chondrosarcoma with intermediate filament positive hyaline-like globules
81. Malignant rhabdoid tumor arising from soft parts of the right thigh with unusual neurologic manifestation: Report of a case
82. Kaposi-like infantile hemangioendothelioma: A distinctive vascular neoplasm of the retroperitoneum
83. Malignant fibrous histiocytoma showing cytoplasmic hyaline globules and stromal osteoids: A case report with light and electron microscopic, histochemical, and immunohistochemical study
84. Inflammatory malignant fibrous histiocytoma of the kidney: An immunohistochemical and ultrastructural study
85. The nature of cytoplasmic inclusions in cerebellar haemangioblastomas: Intracytoplasmic hyaline globules present in stromal cells in eight of a series of ten cerebellar haemangioblastomas have been shown to contain the glycoprotein alpha-1-antitrypsin
86. Hyaline inclusions (Pseudopsammoma bodies) in meningiomas: Immunocytochemical demonstration of epithel-like secretion of secretory component and immunoglobulins A and M
87. Tumor type is a determinant of susceptibility to apoptosis
88. Tumors of the ovary and maldeveloped gonads