Antibody production by molecular farming in plants

Journal of Biological Regulators and Homeostatic Agents

Volumn 14, Issue 2, 2000, Pages 83-92

  Fischer, R ^a   Hoffmann, K ^a   Schillberg, S ^a   Emans, N ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Molecular farming; Molecular medicine; Recombinant antibody; Transgenic plant

Indexed keywords

ANTINEOPLASTIC AGENT; RECOMBINANT PROTEIN;

AGRICULTURE; ANTIBODY PRODUCTION; ASSAY; BIOREACTOR; CELL CULTURE; CELL LINE; CELL SUSPENSION; COMBINATORIAL LIBRARY; ECONOMICS; INDUSTRY; MAMMAL; MEDICINE; MOLECULAR BIOLOGY; NONHUMAN; PHARMACEUTICS; PLANT; PLANT CELL; PLANT SEED; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN TARGETING; REVIEW; TRANSGENIC PLANT;

ANIMALIA; EMBRYOPHYTA; MAMMALIA; SPERMATOPHYTA;

EID: 0034520581     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Heterologous protein production in transgenic plants
2. Reduced virus infectivity in N. tabacum secreting a TMV-specific full size antibody
3. Transient expression of a tumor-specific single chain fragment and a chimeric antibody in tobacco leaves
4. A humanized monoclonal antibody produced in transgenic plants for immunoprotection of the vagina against genital herpes
5. An Agrobacterium mediated transient gene expression system for intact leaves
6. Immunotherapeutic potential of antibodies produced in plants
7. Plant antibodies for immunotherapy
8. Production of a foreign protein product with genetically modified plant cells
9. Stable accumulation of Aspergillus niger phytase in transgenic tobacco leaves
10. Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture
11. Production of correctly processed human serum albumin in transgenic plants
12. Transgenic plants as vaccine production systems
13. Presentation of heterologous peptides on plant viruses- genetics, structure and function
14. Intracellular expression of TMV-specific single-chain Fv fragments leads to improved virus resistance in Nicotiana tabacum
15. Seed-specific immunomodulation of abscisic acid activity induces a developmental switch
16. Expression of bacterial genes in plant cells
17. The use of Tiplasmids as plant-directed gene vectors
18. Strategies for variety-independent genetic transformation of important cereals, legumes and woody species utilizing particle bombardment
19. Particle gun-mediated transformation
20. Production of antibodies in transgenic plants
21. Synthesis and selfassembly of a functional monoclonal antibody in transgenic Nicotiana tabacum
22. Continuous cultures of fused cells secreting antibody of predefined specificity
23. Hybrid antibodies
24. Costimulation of T-cell proliferation by a chimeric B7-antibody fusion protein
25. Biological therapy of ovarian cancer: Current directions
26. Making antibodies by phage display technology
27. Large scale insect and plant cell culture
28. Bacterial expression of immunoglobulin fragments
29. Recombinant protein production in transgenic animals
30. N-Glycosylation of a mouse IgG expressed in transgenic tobacco plants
31. Production of monoclonal antibodies in plants
32. Characterization and applications of antibodies produced in plants
33. Assembly of antibodies and mutagenized variants in transgenic plants and plant cell cultures
34. Antibodies produced in plants
35. Expression in tobacco of a functional monoclonal antibody specific to stylet secretions of the root-knot nematode
36. Intact antigen-binding MAK33 antibody and Fab fragment accumulate in intercellular spaces of Arabidopsis thaliana
37. Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants
38. Assembly of an antibody and its derived antibody fragments in Nicotiana and Arabidopsis
39. Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack
40. Synthesis of a functional anti-phytochrome single-chain Fv protein in transgenic tobacco
41. The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both cytosol and the secretory pathway in transgenic tobacco
42. Secretion of a functional single-chain Fv protein in transgenic tobacco plants and cell suspension cultures
43. Expression of single-chain antibody fragments (scFv) specific for beet necrotic yellow vein virus coat protein or 25kDa protein in Escherichia coli and Nicotiana benthamiana
44. Expression of a single-chain Fv antibody against abscisic acid creates a wilty phenotype in transgenic tobacco
45. High-level production and long-term storage of engineered antibodies in transgenic tobacco seeds
46. Production of recombinant proteins in transgenic plants: Practical considerations
47. Compartment-specific accumulation of recombinant immunoglobulins in plant cells: An essential tool for antibody production and immunomodulation of physiological functions and pathogen activity
48. High level accumulation of single-chain variable fragments in the cytosol of transgenic Petunia hybrida
49. Correlation between in vitro stability and in vivo performance of anti- GCN4 intrabodies as cytoplasmic inhibitors
50. Coordinate expression of antibody subunit genes yields high levels of functional antibodies in roots of transgenic tobacco
51. Optimisation of scFv antibody production in transgenic plants
52. Generation and assembly of secretory antibodies in plants
53. High level and stable accumulation of Single chain Fv antibodies in plant storage organs
54. Potato tubers as a biofactory for recombinant antibodies
55. An Agrobacterium-mediated transient gene expression system for intact leaves
56. Plant virus gene vectors for transient expression of foreign proteins in plants
57. Rapid production of specific vaccines for lymphoma by expression of the tumor-derived single-chain Fv epitopes in tobacco plants
58. Transformation technology
59. High efficiency transformation of cultured tobacco cells
60. Use of viral replicons for the expression of genes in plants
61. Expression of a single chain antibody in plants using a viral vector
62. Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector
63. Vectors based on maize streak virus can replaicate to high copy numbers in maize plants
64. A simple and general method for transferring genes into plants
65. Accumulation of a thermostable endo-1,4-b-D-glucanase in the apoplast of Arabidopsis thaliana leaves
66. Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
67. Production of antibodies in transgenic plants
68. Subcellular targeting and purification of recombinant proteins in plant production systems
69. Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture
70. Transgenic plants as bioreactors for the expression of recombinant antibodies
71. Characterisation and applications of plant-derived recombinant antibodies
72. Antibody expression in transgenic plants
73. Expression and characterisation of single-chain antibody fragments produced in transgenic plants against the organic herbicides atrazine and paraquat
74. Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
75. Commercial production of Avidin from transgenic maize: Characterization of transformant, production, processing, extraction and purification
76. Molecular farming of industrial proteins from transgenic maize