Postnatal lethality of P-cadherin/desmoglein 3 double knockout mice: Demonstration of a cooperative effect of these cell adhesion molecules in tissue homeostasis of stratified squamous epithelia

Journal of Investigative Dermatology

Volumn 114, Issue 5, 2000, Pages 948-952

  Lenox, Jennifer M ^a   Koch, Peter J ^a,c   Mahoney, My G ^a,d   Lieberman, Melanie ^a   Stanley, John R ^a   Radice, Glenn L ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Adherens junction; Desmosome; Oral mucosa; Pemphigus vulgaris

Indexed keywords

CADHERIN; CADHERIN P; DESMOGLEIN; DESMOGLEIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL ULTRASTRUCTURE; GENOTYPE; HISTOPATHOLOGY; KERATINOCYTE; MOUSE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

EID: 0034080756     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2000.00976.x     Document Type: Article

References (18)

1. Amagai M, Fujimori T, Masunaga T, et al: Delayed assembly of desmosomes in keratinocytes with disrupted classic-cadherin-mediated cell adhesion by a dominant negative mutant. J Invest Dermatol 104:27-32, 1995
2. Daniel CW, Strickland P, Friedmann Y: Expression and functional role of E-and P-cadherins in mouse mammary ductal morphogenesis and growth. Dev Biol 169:511-519, 1995
3. Hatta M, Miyatani S, Copeland NG, Gilbert DJ, Jenkins NA, Takeichi M: Genomic organization and chromosomal mapping of the mouse P-cadherin gene. Nucl Acids Res 19:4437-4441, 1991
4. Hirai Y, Nose A, Kobayashi S, Takeichi M: Expression and role of E-and P-cadherin adhesion molecules in embryonic histogenesis: II. Skin morphogenesis. Development 105:271-277, 1989
5. King IA, Angst BD, Hunt DM, Kruger M, Arnemann J, Buxton RS: Hierarchical expression of desmosomal cadherins during stratified epithelial morphogenesis in the mouse. Differentiation 62:83-96, 1997
6. Koch PJ, Franke WW: Desmosomal cadherins: another growing multigene family of adhesion molecules. Curr Opin Cell Biol 6:682-687, 1994
7. Koch PJ, Mahoney MG, Ishikawa H, et al: Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 137:1091-1102, 1997
8. Koch PJ, Mahoney MG, Cotsarelis G, Rothenberger K, Lavker RM, Stanley JR: Desmoglein 3 anchors telogen hair in the follicle. J Cell Sci 111:2529-2537, 1998
9. Larue L, Ohsugi M, Hirchenhain J, Kemler R: E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc Natl Acad Sci USA 91:8263-8267, 1994
10. Lavker RM, Dong G, Zheng P, Murphy GF: Hairless micropig skin. A novel model for studies of cutaneous biology. Am J Pathol 138:687-697, 1991
11. Lewis JE, Jensen PJ, Wheelock MJ: Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium. J Invest Dermatol 102:870-877, 1994
12. Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR: Explanation for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 104:461-468, 1999
13. Nose A, Takeichi M: A novel cadherin cell adhesion molecule: its expression patterns associated with implantation and organogenesis of mouse embryos. J Cell Biol 103:2649-2658, 1986
14. Radice GL, Ferreira-Cornwell MC, Robinson SD, Rayburn H, Chodosh LA, Takeichi M, Hynes RO: Precocious mammary gland development in P-cadherin-deficient mice. J Cell Biol 139:1025-1032, 1997
15. Riethmacher D, Brinkmann V, Birchmeier C: A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc Natl Acad Sci USA 92:855-859, 1995
16. Shirayoshi Y, Nose A, Iwasaki K, Takeichi M: N-linked oligosaccharides are not involved in the function of a cell-cell binding glycoprotein E-cadherin. Cell Struct Funct 11:245-252, 1986
17. Stanley JR: Cell adhesion molecules as targets of autoantibodies in pemphigus and pemphigoid-bullous diseases due to defective epidermal cell adhesion. Adv Immunol 53:291-325, 1993
18. Yap AS, Brieher WM, Gumbiner GM: Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol 13:199-146, 1997