Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia

American Journal of Pathology

Volumn 157, Issue 3, 2000, Pages 1039-1050

  Rodriguez Puebla, Marcelo L ^a   LaCava, Margaret ^a   Miliani de Marval, Paula L ^a   Jorcano, Jose L ^b   Richie, Ellen R ^a   Conti, Claudio J ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b CIEMAT   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN D2; CYCLIN D3; KERATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; EPIDERMIS; EPIDERMIS HYPERPLASIA; GENE OVEREXPRESSION; MOUSE; NONHUMAN; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SQUAMOUS CELL; THYMUS HYPERPLASIA; TRANSGENIC MOUSE;

EID: 0034495082     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64616-0     Document Type: Article

References (47)

1. 1 cyclins
2. D-type cyclins
3. 1 phase progression: Cyclin on cue
4. Transforming growth factor B1 regulation of c-myc expression, pRb phosphorylation, and cell cycle progression in keratinocytes
5. E2F transcription factor is a target for the RB protein and the cyclin A protein
6. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
7. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase
8. 1 kinase activity for cdk6, a novel cyclin D partner
9. D-type cyclins complex bind with the androgen receptor and inhibits its transcriptional transactivation ability
10. CDK-independent activation of estrogen receptor by cyclin D1
11. P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor
12. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4
13. Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma
14. The 5D4 antibody (anti-cyclin D1/D2) related antigen: Cytoplasmic staining is correlated to the progression of gastric cancer
15. A genetic perspective of male germ cell tumors
16. Aberrant expression of cyclin D2 in an early event in human male germ cell tumorigenesis
17. Overexpression of cyclin D2 in chronic B-cell malignancies
18. Anomalous high p27/Kip1 expression in a subset of aggressive B-cell lymphomas is associated with cyclin D3 overexpression. p27/Kip1-cyclin D3 colocalization in tumor cells
19. Cyclin d1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer
20. 1/S transition by cyclin D2 and D3 in hematopoietic cells
21. 1 cyclins D2 and D3 but not D1
22. 1/S transition anf high abundance in quiescent tissues suggest a dual role in proliferation and differentiation
23. Cyclin D1 provides a link between development and oncogenesis in the retina and breast
24. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
25. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
26. Morphological evaluation of tumor promoter effects on mammalian skin
27. Deregulated expression of cell-cycle proteins during premalignant progression in SENCAR mouse skin
28. 1 cyclins and cyclin-dependent kinases during tumor progression of chemically induced mouse skin neoplasms
29. Synchronized proliferation induced by TPA treatment of mouse skin: An in vivo model for cell cycle regulation
30. Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia
31. Transgenic expression of cyclin D1 in thymic epithelial precursors promotes epithelial and T cell development
32. Sequences 5′ of the bovine keratin 5 gene direct tissue- and cell-type-specific expression of a lacZ gene in the adult and during development
33. Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicles development and skin structure
34. Tumor suppressor genes
35. Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene
36. Cloning of a D-type cyclin from murine erythroleukemia cells
37. 1 phase of the cell cycle
38. Early overexpression of cyclin D1 protein in mouse skin carcinogenesis
39. Overexpression of cyclin D1 in mouse skin carcinogenesis
40. Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors
41. Reduced skin tumor development in cyclin D1 deficient mice highlights the oncogenic ras pathway in vivo
42. Cyclin D1 overexpression in mouse epidermis increases cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development
43. Characterization of the mouse cyclin D3 gene: Exon/intron organization and promoter activity
44. PRAD1/cyclin D1 proto-oncogene: Genomic organization 5′ DNA sequence of a tumor-specific rearrangement breakpoint
45. The transcription factor E2F-1 mediates the autoregulation of Rb gene expression
46. Expression of the positive regulator of cell cycle progression, cyclin D3, is reduced during differentiation of myoblasts into quiescent myotubes
47. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer