Effects of anisotropy on the development of cardiac arrhythmias associated with focal activity

Pflugers Archiv European Journal of Physiology

Volumn 441, Issue 2-3, 2000, Pages 301-312

  Wilders, Ronald ^a,b   Wagner, Mary B ^c   Golod, David A ^c   Kumar, Rajiv ^c   Wang, Yang Gan ^c   Goolsby, William N ^c   Joyner, Ronald W ^c   Jongsma, Habo J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anisotropy; Computer simulations; Electrophysiology; Gap junctions; Heart; Ischemia; Ventricular cells

Indexed keywords

ANIMAL CELL; ANISOTROPY; ARTICLE; CELL CONTACT; CELL COUNT; COMPUTER SIMULATION; CONDUCTANCE; CONTROLLED STUDY; GAP JUNCTION; HEART ARRHYTHMIA; HEART MUSCLE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ACTION POTENTIALS; ANISOTROPY; ARRHYTHMIA; CELL COMMUNICATION; COMPUTER SIMULATION; ELECTRIC CONDUCTIVITY; GAP JUNCTIONS; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; MYOCARDIAL ISCHEMIA;

EID: 0034492651     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004240000413     Document Type: Article

References (44)

1. Effects of gap junction conductance on dynamics of sinoatrial node cells: Two-cell and large-scale network models
2. Directional differences of impulse spread in trabecular muscle from mammalian heart
3. Abnormal automaticity as mechanism of atrial tachycardia in the human heart - Electrophysiologic and histologic correlation: A case report
4. Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts
5. Anisotropic conduction in monolayers of neonatal rat heart cells cultured on collagen substrate
6. Cardiac tissue geometry as a determinant of unidirectional conduction block: Assessment of microscopic excitation spread by optical mapping in patterned cell cultures and in a computer model
7. Block of impulse propagation at an abrupt tissue expansion: Evaluation of the critical strand diameter in 2- and 3-dimensional computer models
8. Role of wavefront curvature in propagation of cardiac impulse
9. Strength-duration curves in cardiac Purkinje fibres: Effects of liminal length and charge distribution
10. Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts
11. Endocardial and epicardial activation pathways of the canine right atrium
12. Nonstationary vortexlike reentrant activity as a mechanism of polymorphic ventricular tachycardia in the isolated rabbit heart
13. Distribution and three-dimensional structure of intercellular junctions in canine myocardium
14. Gap junctions in cardiovascular disease
15. Simulation of action potential propagation in an inhomogeneous sheet of coupled excitable cells
16. Propagation through electrically coupled cells. How a small SA node drives a large atrium
17. A spontaneously active focus drives a model atrial sheet more easily than a model ventricular sheet
18. Alterations in endocardial activation of the canine papillary muscle early and late after myocardial infarction
19. Changes in conduction velocity during acute ischemia in ventricular myocardium of the isolated porcine heart
20. An experimental model for an ectopic focus coupled to ventricular cells
21. Simulation of two-dimensional anisotropic cardiac reentry effects of the wavelength on the reentry characteristics
22. Current thresholds and liminal size in excitation of heart muscle
23. Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43
24. Remodeling of ventricular conduction pathways in healed canine infarct border zones
25. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
26. Interactions between structure and function in sudden cardiac death
27. The relation of Rushton's "liminal length" for excitation to the resting and active conductances of excitable cells
28. Cable analysis in quiescent and active sheep Purkinje fibres
29. Influence of electrical coupling on early after depolarizations in ventricular myocytes
30. Anisotropic conduction and reentry in perfused epicardium of rabbit left ventricle
31. Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling
32. Altered patterns of gap junction distribution in ischemic heart disease. An immunohistochemical study of human myocardium using laser scanning confocal microscopy
33. The relation between discontinuous propagation in anisotropic cardiac muscle and the "vulnerable period" of reentry
34. The stochastic nature of cardiac propagation at a microscopic level. Electrical description of myocardial architecture and its application to conduction
35. Electrophysiological effects of remodeling cardiac gap junctions and cell size: Experimental and model studies of normal cardiac growth
36. Extracellular potentials related to intracellular action potentials during impulse conduction in anisotropic canine cardiac muscle
37. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing
38. Modulation of propagation from an ectopic focus by electrical load and by extracellular potassium
39. Electrical interactions between a real ventricular cell and an anisotropic two-dimensional sheet of model cells
40. Pacemaker activity of the rabbit sinoatrial node. A comparison of mathematical models
41. Action potential conduction between a ventricular cell model and an isolated ventricular cell
42. Model clamp and its application to synchronization of rabbit sinoatrial node cells
43. Generation and propagation of ectopic beats induced by spatially localized Na-K pump inhibition in atrial network models
44. + current in ventricular myocytes of the guinea pig type. Theoretical formulation and their role in repolarization