Tumour necrosis factor-α does not influence proliferation and differentiation of healthy and psoriatic keratinocytes in a skin-equivalent model

Acta Dermato-Venereologica

Volumn 80, Issue 6, 2000, Pages 416-420

  Fransson, J ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Differentiation markers; Fibroblasts; Ki 67; Proliferation markers

Indexed keywords

CYTOKERATIN; CYTOKERATIN 16; EPIDERMAL GROWTH FACTOR RECEPTOR; FILAGGRIN; INVOLUCRIN; KI 67 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST; HUMAN; HUMAN TISSUE; KERATINOCYTE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; REGENERATION;

ADULT; AGED; BIOPSY, NEEDLE; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CULTURE MEDIA; FEMALE; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; KERATINOCYTES; MALE; MIDDLE AGED; PROBABILITY; PSORIASIS; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SKIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034487292     PISSN: 00015555     EISSN: None     Source Type: Journal    
DOI: 10.1080/000155500300012792     Document Type: Article

References (26)

1. Nude mouse-human skin graft model III. Studies on generalized psoriasis
2. Psoriasiform architecture of murine epidermis overlying human psoriatic dermis transplanted onto SCID mice
3. Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro
4. Proliferation and interferon-γ receptor expression in psoriatic and healthy keratinocytes are influenced by interactions between keratinocytes and fibroblasts in a skin equivalent model
5. The effect of IFNγ on healthy and psoriatic keratinocytes in a skin equivalent model is influenced by the source of the keratinocytes and by their interactions with fibroblasts
6. Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-l or tumour necrosis factor
7. Marked synergism between tumour necrosis factor-α and interferon-γ in regulation of keratinocyte-derived adhesion molecules and chemotactic factors
8. An important role of tumour necrosis factor-α in the induction of adhesion molecules in psoriasis
9. Elevated tumour necrosis factor-alpha (TNF-α) biological activity in psoriatic skin lesions
10. A TNF-α promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis
11. Combined analysis of polymorphisms of the tumour necrosis factor-α and interleukin-10 promoter regions and polymorphic xenobiotic metabolising enzymes in psoriasis
12. Role of increased production of monocytes TNF-α, IL-1 and IL-6 in psoriasis: Relation to focal infection, disease activity and responses to treatments
13. Binding and biological effects of tumor necrosis factor alpha on cultured human neonatal foreskin keratinocytes
14. Subcutaneous perfusion of tumour necrosis factor induces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis
15. A new method for studying epidermalization in vitro
16. Epidermal growth in the skin equivalent
17. Development and use of a living skin equivalent
18. Psoriatic fibroblasts secrete lower amounts of IL-6 than healthy fibroblasts before and after stimulation with TNF-α
19. Effects of human recombinant tumour necrosis factor-α (TNF-α) on the proliferative potential of human keratinocytes cultured in serum-free medium
20. Normal response to tumour necrosis factor-alpha and transforming growth factor-beta by keratinocytes in psoriasis
21. In vivo effects of cytokines on psoriatic skin grafted on nude mice: Involvement of the tumour necrosis factor (TNF) receptor
22. The cytokine network
23. Inhibitors of tumor necrosis Factor for rheumatoid arthritis
24. Antitumour necrosis factor therapy for inflammatory bowel disease: A review of agents, pharmacology, clinical results, and safety
25. Response to tumour necrosis factor in two cases of psoriasis
26. Systemic TNF administration in psoriatic patients: A promising therapeutic modality for severe psoriasis