The effect of IFN-γ on healthy and psoriatic keratinocytes in a skin equivalent model is influenced by the source of the keratinocytes and by their interactions with fibroblasts

Archives of Dermatological Research

Volumn 289, Issue 1, 1996, Pages 14-20

  Fransson, Jessica ^a   Shen, Qian ^a   Scheynius, Annika ^a   Hammar, Hans ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Differentiation; IFN ; Psoriasis; Skin equivalent

Indexed keywords

CYTOKERATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FILAGGRIN; GAMMA INTERFERON; INVOLUCRIN; MARKER;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL INTERACTION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MALE; PATHOGENESIS; PRIORITY JOURNAL; PSORIASIS;

ADULT; AGED; CASE-CONTROL STUDIES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL DIVISION; CULTURE TECHNIQUES; FEMALE; FIBROBLASTS; HLA-DR ANTIGENS; HUMANS; INTERFERON-GAMMA, RECOMBINANT; KERATINOCYTES; MALE; MIDDLE AGED; PSORIASIS;

EID: 0030452059     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004030050146     Document Type: Article

References (28)

1. Priestley GC, Adams LW (1983) Hyperactivity of fibroblasts cultured from psoriatic skin: I. Faster proliferation and effect of serum withdrawal. Br J Dermatol 109:149-156
2. Gottlieb A, Chang C, Posnett D, Fanelli B, Tam J (1988) Detection of transforming growth factor α in normal, malignant and hyperproliferative human keratinocytes. J Exp Med 167:670-675
3. Grossman R, Krueger J, Yourish D, Granelli-Peperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB (1989) Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci. USA 86:6367-6371
4. Gillitzer R, Berger R, Mielke V, M:uller C, Wolff K, Stingl G (1991) Upper keratinocytes of psoriatic skin lesions express high levels of NAP-1/IL-8 mRNA in situ. J Invest Dermatol 97:73-79
5. Saiag P, Coulomb B, Lebreton C, Bell E, Dubertret L (1985) Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro. Science 230: 669-672
6. Krueger GG, Jorgensen CM (1990) Experimental models for psoriasis. J Invest Dermatol 95:56s-58s
7. Priestley GC, Lord R (1990) Fibroblast-keratinocyte interactions in psoriasis: failure of psoriatic fibroblasts to stimulate keratinocyte proliferation in vitro. Br J Dermatol 123:467-472
8. Boer OJ de, Loos CM van der, Hamerlinck F, Bos JD, Das PK (1994) Reappraisal of in situ immunophenotypic analysis of psoriasis skin: interaction of activated HLA-DR+ immunocompetent cells and endothelial cells is a major feature of psoriatic lesions. Arch Dermatol Res 286:87-96
9. Trinchieri G, Perussia B (1985) Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 6: 131-136
10. Livden JK, Nilsen R, Bjerke JR, Matre R (1989) In situ localization of interferons in psoriatic lesions. Arch Dermatol Res 281:392-397
11. Nickoloff BJ, Basham TY, Merigan TC, Morhenn VB (1984) Antiproliferative effects of recombinant α- and γ-interferons on cultured human keratinocytes. Lab Invest 51:697-701
12. Barker JNWN, Goodlad JR, Ross EL, Yu CC, Groves RW, MacDonald DM (1993) Increased epidermal cell proliferation in normal human skin in vivo following local administration of interferon-gamma. Am J Pathol 142:1091-1097
13. Coulomb B, Saiag P, Bell E, Breitburd F, Lebreton C, Heslan M, Dubertret L (1986) A new method for studying epidermalization in vitro. Br J Dermatol 114:91-101
14. Fransson J, Emilson A, Scheynius A, Hammar H (1995) Proliferation and interferon-gamma receptor expression in psoriatic and healthy keratinocytes are influenced by interactions between keratinocytes and fibroblasts in a skin equivalent model. Arch Dermatol Res:287:517-523
15. Fransson J, Hammar H (1992) Epidermal growth in the skin equivalent. Arch Dermatol Res 284:343-348
16. Bell E, Ehrlich HP, Sher S, Merrill C, Sarber R, Hull B, Nakatsuji T, Church D, Buttle DJ (1981) Development and use of a living skin equivalent. Plast Reconstr Surg 67:386-392
17. Mare S de, Erp PEJ van, Kerkhof PCM van der (1989) Epidermal hyperproliferation assessed by the monoclonal antibody Ks8.12 on frozen sections. J Invest Dermatol 92:130-131
18. Mansbridge JN, Knapp AM (1987) Changes in keratinocyte maturation during wound healing. J Invest Dermatol 89:253-263
19. Oliver AM, Kaawach W, Weiler Mithoff E, Watt A, Abramovich DR, Rayner CR (1991) The differentiation and proliferation of newly formed epidermis on wounds treated with cultured epithelial allografts. Br J Dermatol 125:147-154
20. Basham TY, Nickoloff BJ, Merigan TC, Morhenn VB (1984) Recombinant gamma interferon induces HLA-DR expression on cultured human keratinocytes. J Invest Dermatol 83:88-90
21. Scheynius A, Johansson C, Meide PH van der (1986) In vivo induction of Ia antigens on rat keratinocytes by γ-interferon. Br J Dermatol 115:543-549
22. Barker J, Allen M, MacDonald D (1990) Alterations induced in normal human skin by in vivo interferon-gamma. Br J Dermatol 122:451-458
23. Baker BS, Powles AV, Valdimarsson H, Fry L (1988) An altered response by psoriatic keratinocytes to gamma interferon. Scand J Immunol 28:735-740
24. Nickoloff BJ, Mitra RS, Elder JT, Fisher GJ, Voorhees JJ (1989) Decreased growth inhibition by recombinant gamma interferon is associated with increased transforming growth factor-α production in keratinocytes cultured from psoriatic lesions. Br J Dermatol 121:161-174
25. 125I-epidermal growth factor binding to cultured keratinocytes by antiproliferative molecules gamma interferon, cyclosporin A, and transforming growth factor-beta. J Invest Dermatol 93:799-803
26. Dubertret L, Brunner-Ferber F, Misiti J, Thomas K, Dubertret M-L (1991) Activities of human acidic fibroblast growth factor in an in vitro dermal equivalent model. J Invest Dermatol 97: 793-798
27. Fransson (1995) Psoriasis. An experimental study with emphasis on interactions between the keratinocyte and the fibroblast. Karolinska Institute, Stockholm
28. Scheynius A, Fransson J, Johansson C, Hammar H, Baker B, Fry L, Valdimarsson H (1992) Expression of interferon-gamma receptors in normal and psoriatic skin. J Invest Dermatol 98: 255-258