Hepatocyte growth factor and neuregulin in mammary gland cell morphogenesis

Advances in Experimental Medicine and Biology

Volumn 480, Issue , 2000, Pages 9-18

  Niemann, Catherin ^a,b   Brinkmann, Volker ^a,b   Birchmeier, Walter ^a,b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Hepatocyte Growth Factor; Mammary epithelial cells; Neuregulin; Receptor tyrosine kinase signalling

Indexed keywords

NEU DIFFERENTIATION FACTOR; PROTEIN TYROSINE KINASE; SCATTER FACTOR;

ANIMAL CELL; BREAST CELL; BREAST EPITHELIUM; CELL DIFFERENTIATION; CELL INTERACTION; CONFERENCE PAPER; CONTROLLED STUDY; IN VITRO STUDY; MESENCHYME; MORPHOGENESIS; NONHUMAN; ORGAN CULTURE; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; HEPATOCYTE GROWTH FACTOR; MAMMARY GLANDS, ANIMAL; MICE; MORPHOGENESIS; NEUREGULINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0034470207     PISSN: 00652598     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Molecular aspects of mesenchymal-epithelial interactions
2. Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland
3. New mammary epithelial and fibroblastic cell clones in coculture form structures competent to differentiate functionally
4. Extracellular matrix promotes mammary epithelial growth and differentiation in vitro
5. Multi-faceted regulation of cell differentiation by extracellular matrix
6. Laminin mediates tissue-specific gene expression in mammary epithelia
7. Reconstitution of mammary gland development in vitro: Requirement of c-met and c-erbB2 signalling for branching and alveolar morphogenesis
8. Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells
9. Heregulin induces tyrosine phosphorylation of HER4/p180erbB4
10. A neu acquaintance for erbB3 and erbB4: A role for receptor heterodimerization in growth signalling
11. Neuregulins and their receptors
12. A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway
13. Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation
14. Reversible inhibition of mammary gland growth by transforming growth factor-beta
15. Local effects of EGF, alpha-TGF, and EGF-like growth factors on lobuloalveolar development of the mouse mammary gland in vivo
16. Ductal morphogenesis in the mouse mammary gland: Evidence supporting a role for epidermal growth factor
17. TGF alpha overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas
18. Targeting expression of a transforming growth factor beta 1 transgene to the pregnant mammary gland inhibits alveolar development and lactation
19. Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development
20. Expression and functional properties of transforming growth factor alpha and epidermal growth factor during mouse mammary gland ductal morphogenesis
21. Inhibition of mammary duct development but not alveolar outgrowth during pregnancy in transgenic mice expressing active TGF-beta 1
22. Tissue combination and organ culture studies in the development of the embryonic mammary gland
23. Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland
24. Specificity of tissue interaction and origin of mesenchymal cells in the androgen response of the embryonic mammary gland
25. Developmental response of adult mammary epithelial cells to various fetal and neonatal mesenchymes
26. Role of mesenchymal-epithelial interactions in mammary gland development
27. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor
28. Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors
29. The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells
30. Branching morphogenesis of human mammary epithelial cells in collagen gels
31. Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells
32. Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells
33. Morphogenic effects of neuregulin (Neu Differentiation Factor) in cultured epithelial cells
34. Motogenic and morphogenic activity of epithelial receptor tyrosine kinases
35. A multifunctional docking site mediates signalling and transformation by the hepatocyte growth factor/scatter factor receptor family
36. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cb1 and Gab1
37. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
38. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase
39. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
40. The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras
41. Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis