Morphogenetic effects of neuregulin (neu differentiation factor) in cultured epithelial cells

Molecular Biology of the Cell

Volumn 9, Issue 11, 1998, Pages 3195-3209

  Chausovsky, Alexander ^a   Tsarfaty, Ilan ^b   Kam, Zvi ^a   Yarden, Yosef ^a   Geiger, Benjamin ^a   Bershadsky, Alexander D ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

NEU DIFFERENTIATION FACTOR; SCATTER FACTOR;

ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOARCHITECTURE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STOMACH EPITHELIUM;

EID: 0031739613     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.11.3195     Document Type: Article

References (55)

1. Birchmeier, W., and Birchmeier, C. (1995). Epithelial-mesenchymal transition in development and tumor progression. In: Epithelial-Mesenchymal Interactions in Cancer, ed. I.D. Goldberg and E.M. Rosen, Basel: Birkhäuser Verlag, 1-15.
2. Bokoch, G.M., Vlahos, C.J., Wang, Y., Knaus, U.G., and Traynor-Kaplan, A.E. (1996). Rac GTPase interacts specifically with phosphatidylinositol 3-kinase. Biochem. J. 315, 775-779.
3. Bottaro, D.P., Rubin, J.S., Faletto, D.L., Chan, A.M., Kmiecik, T.E., Vande Woude, G.F., and Aaronson, S.A. (1991). Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251, 802-804.
4. Boyer, B., Valles, A.M., Tucker, G.C., Delouvee, A., and Thiery, J.P. (1993). Involvement of cell motility in tumor progression. Symp. Soc. Exp. Biol. 47, 183-195.
5. Bray, D. (1992). Cell Movements, New York: Garland Publishing.
6. Britsch, S., Li, L., Kirchhoff, S., Theuring, F., Brinkmann, V., Birchmeier, C., and Riethmacher, D. (1998). The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12, 1825-1836.
7. Burden, S., and Yarden, Y. (1997). Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 18, 847-855.
8. Carraway, K.L., III, Soltoff, S.P., Diamond, A.J., and Cantley, L.C. (1995). Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3. J. Biol. Chem. 270, 7111-7116.
9. Clark, P. (1994). Modulation of scatter factor/hepatocyte growth factor activity by cell-substratum adhesion. J. Cell Sci. 107, 1265-1275.
10. Cochet, C., Kashles, O., Chambaz, E.M., Borrello, I., King, C.R., and Schlessinger, J. (1988). Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical crosslinking agent. J. Biol. Chem. 263, 3290-3295.
11. Danilenko, D.M., Ring, B.D., Lu, J.Z., Tarpley, J.E., Chang, D., Liu, N., Wen, D., and Pierce, G.F. (1995). Neu differentiation factor upregulates epidermal migration and integrin expression in excisional wounds. J. Clin. Invest. 95, 842-851.
12. Erickson, S., Shea, K., Ghaboosi, N., Loverro, L., Frantz, G., Bauer, M., Lu, L., and Moore, M. (1997). ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2- and heregulin-deficient mice. Development 124, 4999-5011.
13. Gassmann, M., Casagranda, F., Orioli, D., Simon, H., Lai, C., Klein, R., and Lemke, G. (1995). Aberant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390-394.
14. Gherardi, E., Sharpe, M., Lane, K., Sirulnik, A., and Stoker, M. (1993). Hepatocyte growth factor/scatter factor (HGF/SF), the c-met receptor and the behavior of epithelial cells. Symp. Soc. Exp. Biol. 47, 163-181.
15. Hay, E.D. (1995). An overview of epithelio-mesenchymal transformation. Acta Anat. 154, 8-20.
16. Jones, F.E., Jerry, D.J., Guarino, B.C., Andrews, G.C., and Stern, D.F. (1996). Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli. Cell Growth Differ. 7, 1031-1038.
17. Keydar, I., Chen, L., Karby, S., Weiss, F.R., Delarea, J., Radu, M., Chaitcik, S., and Brenner, H.J. (1979). Establishment and characterization of a cell line of human breast carcinoma origin. Eur. J. Cancer 15, 659-670.
18. Kjelsberg, C., Sakurai, H., Spokes, K., Birchmeier, C., Drummond, I., Nigam, S., and Cantley, L.G. (1997). Met-/- kidneys express epithelial cells that chemotax and form tubules in response to EGF receptor ligands. Am. J. Physiol. 272, F222-F228.
19. Klemke, R.L., Cai, S., Giannini, A.L., Gallagher, P.J., Lanerolle, P., and Cheresh, D.A. (1997). Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137, 481-492.
20. Lee, J., Dull, T.J., Lax, I., Schlessinger, J., and Ullrich, A. (1989). HER-2 cytoplasmic domain generates normal mitogenic and transforming signals in a chimeric receptor. EMBO J. 8, 167-173.
21. Lee, K.F., Simon, H., Chen, H., Bates, B., Hung, M.C., and Hauser, C. (1995). Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394-398.
22. Lehvaslaiho, H., Lehtola, L., Sistonen, L., and Alitalo, K. (1989). A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation. EMBO J. 8, 159-166.
23. Ma, J., Maliepaard, M., Kolker, H.J., Verweij, J., and Schellens, J.H. (1998). Abrogated energy-dependent uptake of cisplatin in a cisplatin-resistant subline of the human ovarian cancer cell line IGROV-1. Cancer Chemother. Pharmacol. 41, 186-192.
24. Mahanthappa, N.K., Anton, E.S., and Matthew, W.D. (1996). Glial growth factor 2, a soluble neuregulin, directly increases Schwann cell motility and indirectly promotes neurite outgrowth. J. Neurosci. 26, 4673-4683.
25. Meyer, D., and Birchmeier, C. (1995). Multiple essential function of neuregulin in development. Nature 378, 386-390.
26. Montesano, R., Matsumoto, K., Nakamura, T., and Orci, L. (1991). Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 67, 901-908.
27. Myers, R.B., Srivastava, S., Oelschlager, D.K., and Grizzle, W.E. (1994). Expression of p160erbB-3 and p185erbB-2 in prostatic intraepithelial neoplasia and prostatic adenocarcinoma. J. Natl. Cancer Inst. 86, 1140-1145.
28. Naldini, L., et al. (1991). Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 10, 2867-2878.
29. Park, J.G., et al. (1990). Characteristics of cell lines established from human gastric carcinoma. Cancer Res. 50, 2773-2780.
30. Peles, E., Lamprecht, R., Ben-Levy, R., Tzahar, E., and Yarden, Y. (1992). Regulated coupling of the Neu receptor to phosphatidylinositol 3′-kinase and its release by oncogenic activation. J. Biol. Chem. 267, 12266-12274.
31. Pielou, E.C. (1969). An Introduction to Mathematical Ecology, New York: John Wiley & Sons.
32. Potempa, S., and Ridley, A.J. (1998). Activation of both MAP kinase and phosphatidylinositide 3-kinase by ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol. Biol. Cell 9, 2185-2200.
33. Reif, K., Nobes, C.D., Thomas, G., Hall, A., and Cantrell, D.A. (1996). Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr. Biol. 6, 1445-1456.
34. Riethmacher, D., Sonnenberg-Riethmacher, E., Brinkmann, V., Yamaai, T., Levin, G., and Birchmeier, C. (1997). Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature 389, 725-730.
35. Rong, S., Oskarsson, M., Faletto, D., Tsarfaty, I., Resau, J.H., Nakamura, T., Rosen, E., Hopkins, R.F., and Vande Woude, G.F. (1993). Tumorigenesis induced by coexpression of human hepatocyte growth factor and the human met protooncogene leads to high levels of expression of the ligand and receptor. Cell Growth Differ. 4, 563-569.
36. Sachs, M., Weidner, K.M., Brinkmann, V., Walther, I., Obermeier, A., Ullrich, A., and Birchmeier, W. (1996). Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. J. Cell Biol. 135, 1095-1107.
37. Savagner, P., Boyer, B., Valles, A.M., Jouanneau, J., and Thiery, J.P. (1994). Modulations of the epithelial phenotype during embryogenesis and cancer progression. In: Mammary Tumorigenesis and Malignant Progression, ed. R. Dickson and M. Lippman, Norwell, MA: Kluwer Academic, 229-249
38. Savagner, P., Yamada, K., and Thiery, J. (1997). The zink-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J. Cell Biol. 137, 1403-1419.
39. Soriano, J.V., Pepper, M.S., Nakamura, T., Orci, L., and Montesano, R. (1995). Hepatocyte growth factor stimulates extensive develop-ment of branching duct-like structures by cloned mammary gland epithelial cells. J. Cell Sci. 208, 413-430.
40. Stoker, M., Gherardi, E., Ferryman, M., and Gray, J. (1987). Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327, 239-242.
41. Stone, K.R., Mickey, D.D., Wunderli, H., Mickey, G.H., and Paulson, D.F. (1978). Isolation of a human prostate carcinoma cell line (DU 145). Int. J. Cancer 21, 274-281.
42. Tamagnone, L., and Comoglio, P.M. (1997). Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors. Cytokine Growth Factor Rev. 8, 129-142.
43. Tanse, M.G., Chu, G.C., and Merlie, J.P. (1996). ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/ MAPK pathway. J. Cell Biol. 134, 465-476.
44. Trinkaus, J.P. (1984). Cells into Organs: The Forces That Shape the Embryo, Englewood Cliffs, NJ: Prentice-Hall.
45. Tsarfaty, I., Resau, J.H., Rulong, S., Keydar, I., Faletto, D., and Vande Woude, G.F. (1992). The met proto-oncogene and lumen formation. Science 257, 1258-1261.
46. Tsarfaty, I., Rong, S., Resau, J.H., Rulong, S., da Silva, P.P., and Vande Woude, G.F. (1994). The Met proto-oncogene mesenchymal to epithelial cell conversion. Science 263, 98-101.
47. Tzahar, E., et al. (1994). ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/ heregulin isoforms. J. Biol. Chem. 269, 25226-25233.
48. Tzahar, E., Waterman, H., Chen, X., Levkowitz, G., Karunagaran, D., Lavi, S., Ratzkin, B.J., and Yarden, Y. (1996). A hierarchical network of interreceptor interactions determines signal transdution by Neu differentiation factor/neuregulin and epidermal growth factor. Mol. Cell. Biol. 16, 5276-5287.
49. Tzahar, E., and Yarden, Y. (1998). The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands. Biochim. Biophys. Acta 1377, M25-M37.
50. Ullrich, A., and Schlessinger, J. (1990). Signal transduction by receptors with tyrosine kinase activity. Cell 61, 203-212.
51. Vande Woude, G.F., Jeffers, M., Cortner, J., Alvord, G., Tsarfaty, I., and Resau, J. (1997) Met-HGF/SF: tumorigenesis, invasion and metastasis. Ciba Found Symp. 212, 119-130.
52. Watabe, M., Matsumoto, K., Nakamura, T., and Takeichi, M. (1993). Effect of hepatocyte growth factor on cadherin-mediated cell-cell adhesion. Cell Struct. Funct. 18, 117-124.
53. Weidner, K.M., Cesare, S.D., Sachs, M., Brinkmann, V., Behrens, J., and Birchmeier, W. (1996). Interaction between Gab 1 and the c-met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384, 173-176.
54. Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K.M., Birchmeier, C., and Birchmeier, W. (1995). Sequential requirement of HGF and neuregulin in the morphogenesis and differentiation of the mammary gland. J. Cell Biol. 131, 215-226.
55. Yarden, Y., and Schlessinger, J. (1987). Epidermal growth factor induces rapid, reversible aggregation of purified epidermal growth factor receptor. Biochemistry 26, 1443-1445.