Changes in rat liver monooxygenase activities after administration of atenolol, nifedipine and diltiazem alone and in combination

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 8, 2000, Pages 627-631

  Kastelova, A ^a   Koleva, M ^a   Staneva Stoytcheva, D ^a  

^a INSTITUTE OF PHYSIOLOGY   (Bulgaria)

Author keywords

Atenolol; Cytochrome P 450; Diltiazem; Nifedipine; Rat liver monooxygenases

Indexed keywords

AMINOPYRINE N DEMETHYLASE; ATENOLOL; CYTOCHROME B5; CYTOCHROME P450; DILTIAZEM; DRUG METABOLIZING ENZYME; ETHYLMORPHINE N DEMETHYLASE; HEXOBARBITAL; NIFEDIPINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNSPECIFIC MONOOXYGENASE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; LIVER METABOLISM; MALE; NONHUMAN; RAT; SLEEP TIME;

ADRENERGIC BETA-ANTAGONISTS; AMINOPYRINE N-DEMETHYLASE; ANILINE HYDROXYLASE; ANIMALS; ATENOLOL; CALCIUM CHANNEL BLOCKERS; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; DILTIAZEM; DRUG THERAPY, COMBINATION; ETHYLMORPHINE-N-DEMETHYLASE; HEXOBARBITAL; HYPNOTICS AND SEDATIVES; LIVER; MALE; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; NIFEDIPINE; OXIDOREDUCTASES; RATS; RATS, WISTAR;

EID: 0034469940     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2000.22.8.802274     Document Type: Article

References (31)

1. Interaction between propranolol and calcium channel blockers in cardiac and vascular smooth muscle
2. Combined β adrenergic and calcium entry blockade in angina pectoris
3. Comparative antihypertensive action of 20 mg delayed-action nifedipine with either 25 or 50 mg atenolol. A study on the treatment of patients with mild to moderately severe arterial hypertension
4. Pharmacological role of the atenolol/ nifedipine combination in hypertensive patients
5. Atenolol/nifedipine combination: Efficacy and tolerability of low dose synergistic biotherapy for the treatment of arterial hypertension
6. Effectiveness of nifedipine GITS in combination with atenolol in chronic stable angina
7. Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
8. Regiochemistry and enantioselectivity in the oxidative N dealkylation of verapamil
9. Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450IIIA4
10. Identification of the rabbit and human cytochromes P-450IIIA as the major enzymes involved in the N-demethylation of diltiazem
11. Pharmacokinetic and pharmacodynamic interactions between nisoldipine and propranolol
12. Metabolic action of a single atenolol metoprolol dose
13. Effect of propranolol, pindolol and atenolol on drug-metabolizing enzyme systems after single administration in rats
14. Effect of propranolol, pindolol and atenolol after multiple administration in rats on the duration of hexobarbital sleeping time and on the activity of some drug-metabolizing enzyme systems
15. Effect of diltiazem on the pharmacokinetics of propranolol, metoprolol and atenolol
16. Pharmacokinetics of diltiazem and propranolol when administered alone and in combination
17. Liver monooxygenase activity after multiple application of nifedipine, verapamil and diltiazem
18. Effect of nifedipine, verapamil and diltiazem on drug-metabolizing enzyme systems after single administration in rats
19. On the enzyme inducing action of calcium antagonists
20. Combined effect of propranolol with nifedipine or with diltiazem on rat liver monooxygenase activities
21. Microsomal enzymes involved in toxicology. Analysis and separation
22. The carbon monooxide binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
23. Purified liver microsomal NADPH-cytochrome P-450 reductase
24. Experiments illustrating drug metabolism in vitro. Determination of aniline hydroxylase
25. The calorimetric estimation of formaldehyde by means of the Hantzch reaction
26. Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil
27. Nifedipine/atenolol interactions in gastrointestinal absorption and biotransformation
28. Hepatic calcium efflux during cytochrome P-450 dependent drug oxidation at the endoplasmatic reticulum in intact liver
29. Calcium antagonistic drugs. Mechanism of action
30. Roles of cytochrome b5 in the oxidation of testosterone and nifedipine by recombinant cytochrome P-450 3A4 and by human liver microsomes
31. Amlodipine versus diltiazem as additional antianginal treatment to atenolol. Centralised European studies in angina research (CESAR) investigators