A human physiologically-based model for glycyrrhzic acid, a compound subject to presystemic metabolism and enterohepatic cycling

Pharmaceutical Research

Volumn 17, Issue 12, 2000, Pages 1516-1525

  Ploeger, B ^a,b   Mensinga, T ^c,d   Sips, A ^c   Meulenbelt, J ^c,d   DeJongh, J ^b  

^a LAP and P Consultants BV   (Netherlands)

^b Leiden Advanced Pharmacokinetics and Pharmacodynamics (LAP and P) Consultants   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Enterohepatic cycling; Glycyrrhizic acid; Modeling; PBPK; Pharmacokinetics

Indexed keywords

GLYCYRRHETINIC ACID; GLYCYRRHIZIC ACID;

AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG ELIMINATION; ENTEROHEPATIC CIRCULATION; GASTROINTESTINAL TRACT; GLYCYRRHIZA; HEALTH HAZARD; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL; STOMACH EMPTYING;

ADULT; ALGORITHMS; ANTI-INFECTIVE AGENTS; AREA UNDER CURVE; BIOTRANSFORMATION; COMPUTER SIMULATION; CROSS-OVER STUDIES; ENTEROHEPATIC CIRCULATION; FEMALE; GLYCYRRHIZIC ACID; HUMANS; MALE; MODELS, BIOLOGICAL; REPRODUCIBILITY OF RESULTS;

EID: 0034469251     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007661209921     Document Type: Article

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