Role and organization of peroxisomal β-oxidation

Advances in Experimental Medicine and Biology

Volumn 466, Issue , 2000, Pages 261-272

  Van Veldhoven, P P ^a   Mannaerts, G P ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A ACETYLTRANSFERASE; ALIPHATIC DICARBOXYLIC ACID; BILE ACID; COENZYME A; LONG CHAIN FATTY ACID; PALMITOYL COENZYME A; PROSTANOID; RACEMASE; XENOBIOTIC AGENT;

ANIMAL TISSUE; CONFERENCE PAPER; DEGRADATION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FATTY ACID DESATURATION; FATTY ACID OXIDATION; HUMAN; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; RAT; STEREOSPECIFICITY;

ACYL-COA DEHYDROGENASE, LONG-CHAIN; ANIMALS; FATTY ACIDS; HUMANS; LIPID METABOLISM; OXIDATION-REDUCTION; OXIDOREDUCTASES; PALMITOYL-COA HYDROLASE; PEROXISOMES; RATS;

ANIMALIA; MAMMALIA;

EID: 0034468491     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (85)

1. A fatty acyl-CoA oxidizing system in rat liver peroxisomes: Enhancement by clofibrate, a hypolipidemic drug
2. Peroxisomal β-oxidation. Enzymology and molecular biology
3. Peroxisomal bifunctional protein from rat liver is a trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and Δ3.Δ2-enoyl-CoA isomerase activities
4. β-oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: A century of continued progress
5. Functions and organization of peroxisomal β-oxidation
6. Inhibition of 3α.7α.12α-trihydroxy-5β-cholestanoic acid oxidation and of bile acid secretion in rat liver by fatty acids
7. Acyl-CoA synthetase in rat liver peroxisomes. Computer-assisted analysis of cell fractionation experiments
8. Evidence that peroxisomal acyl-CoA synthetase is located at the cytoplasmic side of the peroxisomal membrane
9. Mitochondrial and peroxisomal β-oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver
10. Characteristics and subcellular localization of pristanoyl-CoA synthetase in rat liver
11. Activation of 3-methyl-branched fatty acids in rat liver
12. Identification of phytanoyl-CoA ligase as a distinct acyl-CoA ligase in peroxisomes from cultured human skin fibroblasts
13. Phytanic acid activation in rat liver peroxisomes is catalyzed by long chain acyl-CoA synthetase
14. Distinct long chain and very long chain fatty acyl CoA synthetases in rat liver peroxisomes and microsomes
15. Cellular oxidation of lignoceric acid is regulated by the subcellular localization of lignoceroyl-CoA ligases
16. Purification and properties of rat liver peroxisomal very-long-chain acyl-CoA synthetase
17. Molecular cloning of cDNA encoding rat very long-chain acyl-CoA synthetase
18. Topography of very-long-chain-fatty-acid-activating activity in peroxisomes from rat liver
19. Topographical localization of peroxisomal acyl-CoA ligases: Differential localization of palmitoyl-CoA and lignoceroyl-CoA ligases
20. The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae
21. Factors influencing palmitoyl-CoA oxidation by rat liver peroxisomal fractions. Substrate concentration, organelle integrity and ATP
22. The microsomal dicarboxylyl-CoA synthetase
23. 2 in rat liver peroxisomes and mitochondria
24. Subcellular localization of 3α,7α-dihydroxy- and 3α,7α,12α-trihydroxy-5β-cholestanoyl-coenzyme A ligase(s) in rat liver
25. Subcellular distribution and characteristics of trihydroxycoprostanoyl-CoA synthetase in rat liver
26. Presence of three acyl-CoA oxidases in rat liver peroxisomes. An inducible fatty acyl-CoA oxidase, a non-inducible fatty acyl-CoA oxidase and a non-inducible trihydroxycoprostanoyl-CoA oxidase
27. Identification and purification of a branched chain fatty acyl-CoA oxidase
28. Substrate specificities or rat liver peroxisomal acyl-CoA oxidases: Palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase) and trihydroxycoprostanoyl-CoA oxidase
29. Identification of pristanoyl-CoA oxidase as a distinct, clofibrate non-inducible enzyme in rat liver peroxisomes
30. Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase
31. Isolation and structural characterization of the rat acyl-CoA oxidase gene
32. Functional expression of two forms of rat acyl-CoA oxidase and their substrate specificities
33. Large scale purification and further characterization of rat pristanoyl-CoA oxidase
34. Purification of further characterization of peroxisomal trihydroxycoprostanoyl-CoA oxidase from rat liver
35. Rat pristanoyl-CoA oxidase: cDNA cloning and recognition of its C-terminal (SQL) by the PTS1-receptor
36. Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase
37. Implication of a peroxisomal enzyme in the catabolism of glutaryl-CoA
38. CoA esters of valproic acid and related metabolites are oxidized in peroxisomes through a pathway distinct from peroxisomal fatty and bile acyl-CoA β-oxidation
39. The oxidation of dicarboxylic acid CoA esters via peroxisomal fatty acyl-CoA oxidase
40. Separate peroxisomal oxidases for fatty acyl-CoAs and trihydroxycoprostanoyl-CoA in human liver
41. The CoA esters of 2-methyl-branched chain fatty acids and of the bile acid intermediates di- and trihydroxycoprostanic acids are oxidized by one single peroxisomal branched chain acyl-CoA oxidase in human liver and kidney
42. Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy
43. Identification of pristanoyl-CoA oxidase activity in human liver and its deficiency in the Zellweger syndrome
44. Molecular characterization of the human peroxisomal branched chain acyl-CoA oxidase. cDNA cloning, chromosomal assignment, tissue distribution and evidence for the absence of the protein in Zellweger syndrome
45. Assignment of the human branched chain acyl-CoA oxidase to chromosome 3p14.3-p21.1 by rodent/human somatic cell hybridization
46. Evidence for the presence of pristanoyl-CoA oxidase gene in man
47. Atypical riboflavin-responsive glutaric aciduria, and deficient peroxisomal glutaryl-CoA oxidase activity: A new peroxisomal disorder
48. Peroxisomal β-oxidation: Purification of four novel 3-hydroxyacyl-CoA dehydrogenases from rat liver peroxisomes
49. 27 bile acids di- and trihydroxycoprostanic acids are metabolized by separate multifunctional proteins
50. Evidence that multifunctional protein-2 and not multifunctional protein-1 is involved in pristanic acid degradation
51. The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids
52. Peroxisomal multifunctional enzyme of β-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: Molecular cloning, expression and characterization
53. Peroxisome proliferators alter the expression of estrogen-metabolizing enzymes
54. Molecular cloning and amino acid sequence of the porcine 17 β-estradiol dehydrogenase
55. Molecular characterization of mouse 17 β-hydroxysteroid dehydrogenase IV
56. Molecular cloning of a novel widely expressed human 80kDa 17 β-hydroxysteroid dehydrogenase IV
57. Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig. cDNA cloning of the guinea pig D-specific multifunctional protein 2
58. The sequence of porcine 80 kDa 17 β-estradiol dehydrogenase reveals similarities to the short chain alcohol dehydrogenase family, to actin binding motifs and to sterol carrier protein 2
59. cDNA cloning and primary structure determination of the peroxisomal trifunctional enzyme hydratase-dehydrogenase-epimerase from the yeast Candida tropicalis pK233
60. Peroxisomal multifunctional β-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product
61. Porcine 80-kDa protein reveals intrinsic 17 β-hydroxysteroid dehydrogenase, fatty acyl-CoA-hydratase/dehydrogenase, and sterol transfer activities
62. Identification and characterization of the 2-enoyl-CoA hydratases involved in peroxisomal β-oxidation in rat liver
63. The human peroxisomal multifunctional protein involved in bile acid synthesis: Activity measurement, deficiency in Zellweger syndrome and chromosome mapping
64. Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: Medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase
65. Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein
66. Assignment of human 17 β-hydroxysteroid dehydrogenase IV to chromosome 5q2 by fluorescence in situ hybridization
67. Substrate specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA thiolase purified from normal rat liver peroxisomes. Sterol carrier protein 2/3-oxoacyl-CoA thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid intermediates
68. Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes
69. Cloning and sequence determination of cDNA encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase
70. The non-specific lipid-transfer protein (sterol carrier protein 2) and its relationship to peroxisomes
71. Identification of the cDNA clone which encodes the 58-kDa protein containing the amino acid sequence of rat liver non-specific lipid-transfer protein (sterol-carrier protein 2). Homology with rat peroxisomal and mitochondrial 3-oxoacyl-CoA thiolases
72. Sterol carrier protein X is peroxisomal 3-oxoacyl coenzyme A thiolase with intrinsic sterol carrier and lipid transfer activity
73. Sterol carrier protein X (SCPx) is a peroxisomal branched-chain β-ketothiolase specifically reacting with 3-oxo-pristanoyl-CoA: A new, unique role for SCPx in branched-chain fatty acid metabolism in peroxisomes
74. Peroxisomal β-oxidation of 2-methyl-branched acyl-CoA esters: Stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase
75. The chemistry and biochemistry of phytanic, pristanic and related acids
76. Purification and properties of an α-methylacyl-CoA racemase from rat liver
77. Purification and characterization of an α-methylacyl-CoA racemase from human liver
78. 2-Methylacyl racemase: A coupled assay based on the use of pristanoyl-CoA oxidase/peroxidase and reinvestigation of its subcellular distribution in rat and human liver
79. Stereochemistry of peroxisomal and mitochondrial β-oxidation of α-methylacyl-CoAs
80. On the stereospecificity of microsomal 26-hydroxylation in bile acid biosynthesis
81. Biosynthesis of chenodeoxycholic acid in man: Stereospecific side-chain hydroxylations of 5β-cholestane-3α.7α-diol
82. Substrate stereospecificity in oxidation of (25S)-3α,7α, 12α-trihydroxy-5β-cholestanoyl-CoA by peroxisomal trihydroxy-5β-cholestanoyl-CoA oxidase
83. Molecular cloning of cDNA species for rat and mouse liver α-methylacyl-CoA racemases
84. Molecular cloning and expression of a 2-arylpropionyl-coenzyme A epimerase: A key enzyme in the inversion metabolism of Ibuprofen
85. Peroxisomal disorders: A review