A novel mycobacterial antigen relevant to cellular immunity belongs to a family of secreted lipoproteins

Scandinavian Journal of Immunology

Volumn 46, Issue 5, 1997, Pages 445-451

  Oftung, F ^a   Wiker, H G ^b   Deggerdal, A ^c   Mustafa, A S ^d  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c Dynal AS   (Norway)

^d KUWAIT UNIVERSITY   (Kuwait)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE;

ANTIGEN DETECTION; ARTICLE; CELLULAR IMMUNITY; GENE SEQUENCE; HOST RESISTANCE; HUMAN; HUMAN CELL; MYCOBACTERIUM BOVIS; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; STRAIN DIFFERENCE; T LYMPHOCYTE ACTIVATION; TUBERCULOSIS; VACCINE PRODUCTION;

EID: 0030682524     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-150.x     Document Type: Article

References (42)

1. Fine PE. The BCG story: lessons from the past and implications for the future (review). Rev Infect Dis 1989;11:5353-9.
2. Bloom BR. Learning from leprosy: a perspective on immunology and the Third World (review). J Immunol 1986;137:i-x.
3. Emmrich F, Thole J, van Embden J, Kaufmann SH. A recombinant 64 kilodalton protein of Mycobacterium bovis bacillus Calmette-Guerin specifically stimulates human T4 clones reactive to mycobacterial antigens. J Exp Med 1986;163:1024-9.
4. Huygen K, Lozes E, Gilles B et al. Mapping of TH1 helper T-cell epitopes on major secreted mycobacterial antigen 85A in mice infected with live Mycobacterium bovis BCG. Infect Immun 1994;62:363-70.
5. Janson AA, Klatser PR, van der Zee R et al. A systematic molecular analysis of the T cell-stimulating antigens from Mycobacterium leprae with T cell clones of leprosy patients. Identification of a novel M. leprae HSP 70 fragment by M. leprae-specific T cells. J Immunol 1991;147:3530-7.
6. Lamb JR, Rees AD, Bal V et al. Prediction and identification of an HLA-DR-restricted T cell determinant in the 19-kDa protein of Mycobacterium tuberculosis. Eur J Immunol 1988;18:973-6.
7. Mehra V, Bloom BR, Bajardi AC et al. A major T cell antigen of Mycobacterium leprae is a 10-kD heat-shock cognate protein. J Exp Med 1992;175:275-84.
8. Mustafa AS, Gill HK, Nerland A et al. Human T-cell clones recognize a major M. leprae protein antigen expressed in E. coli. Nature 1986;319:63-6.
9. Oftung F, Mustafa AS, Husson R, Young RA, Godal T. Human T cell clones recognize two abundant Mycobacterium tuberculosis protein antigens expressed in Escherichia coli. J Immunol 1987;138:927-31.
10. Oftung F, Mustafa AS, Shinnick TM et al. Epitopes of the Mycobacterium tuberculosis 65-kilodalton protein antigen as recognized by human T cells. J Immunol 1988;141:2749-54.
11. Oftung F, Shinnick TM, Mustafa AS, Lundin KE, Godal T, Nerland AH. Heterogeneity among human T cell clones recognizing an HLA-DR4, Dw4-restricted epitope from the 18-kDa antigen of Mycobacterium leprae defined by synthetic peptides. J Immunol 1990;144:1478-83.
12. Roche PW, Feng CG, Britton WJ. Human T-cell epitopes on the Mycobacterium tuberculosis secreted protein MPT64. Scand J Immunol 1996;43:662-70.
13. Andersen P. Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 1994;62:2536-44.
14. Brandt L, Oettinger T, Holm A, Andersen ÅB, Andersen P. Key epitopes on the ESAT-6 antigen recognized in mice during recall of protective immunity to Mycobacterium tuberculosis. J Immunol 1996;157:3527-33.
15. Horwitz MA, Lee BW, Dillon BJ, Harth G. Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 1995;92:1530-4.
16. Huygen K, Content J, Denis O et al. Immunogenicity and protective efficacy of a tuberculosis DNA vaccine. Nature Medicine 1996;2:857-9.
17. Mustafa AS, Oftung F, Deggerdal A, Gill HK, Young RA, Godal T. Gene isolation with human T lymphocyte probes. Isolation of a gene that expresses an epitope recognized by T cells specific for Mycobacterium bovis BCG and pathogenic mycobacteria. J Immunol 1988;141:2729-33.
18. Mustafa AS, Deggerdal A, Lundin KE, Meloen RM, Shinnick TM, Oftung F. An HLA-DRw53-restricted T-cell epitope from a novel Mycobacterium leprae protein antigen important to the human memory T-cell repertoire against M. leprae. Infect Immun 1994;62:5595-602.
19. Mustafa AS, Oftung F. Long-lasting T-cell reactivity to Mycobacterium leprae antigens in human volunteers vaccinated with killed M. leprae. Vaccine 1993;11:1108-12.
20. Gill HK, Mustafa AS, Godal T. Induction of delayed-type hypersensitivity in human volunteers immunized with a candidate leprosy vaccine consisting of killed Mycobacterium leprae. Bull World Health Organ 1986;64:121-6.
21. Abou-Zeid C, Filley E, Steele J, Rook GA. A simple new method for using antigens separated by polyacrylamide gel electrophoresis to stimulate lymphocytes in vitro after converting bands cut from Western blots into antigen-bearing particles. J Immunol Methods 1987;98:5-10.
22. Filley E, Abou-Zeid C, Waters M, Rook G. The use of antigen-bearing nitrocellulose particles derived from Western blots to study proliferative responses to 27 antigenic fractions from Mycobacterium leprae in patients and controls. Immunology 1989;67:75-80.
23. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-5.
24. Altschul SE, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol 1990;215:403-10.
25. Hayashi S, Wu HC. Lipoproteins in bacteria (review: 125 refs). J Bioenerg Biomembr 1990;22:451-71.
26. Kyte J, Doolittle RF. A simple method for displaying the hydropathic character of a protein. J Mol Biol 1982;157:105-32.
27. Andersen ÅB, Hansen EB. Structure and mapping of antigenic domains of protein antigen b, a 38,000-molecular-weight protein of Mycobacterium tuberculosis. Infect Immun 1989;57:2481-8.
28. Harboe M, Wiker HG. The 38-kDa protein of Mycobacterium tuberculosis: a review (review). J Infect Dis 1992;166:874-84.
29. Harboe M, Nagai S, Wiker HG, Sletten K, Haga S. Homology between the MPB70 and MPB83 proteins of Mycobacterium bovis BCG. Scand J Immunol 1995;42:46-51.
30. Hewinson RG, Michell SL, Russell WP, McAdam RA, Jacobs WR Jr. Molecular characterization of MPT83: a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70. Scand J Immunol 1996;43:490-9.
31. Matsuo T, Matsuo H, Ohara N et al. Cloning and sequencing of an MPB70 homologue corresponding to MPB83 from Mycobacterium bovis BCG. Scand J Immunol 1996;43:483-9.
32. Nagai S, Matsumoto J, Nagasuga T. Specific skin-reactive protein from culture filtrate of Mycobacterium bovis BCG. Infect Immun 1981;31:1152-60.
33. Berthet FX, Rauzier J, Lim EM, Philipp W, Gicquel B, Portnoi D. Characterization of the Mycobacterium tuberculosis erp gene encoding a potential cell surface protein with repetitive structures. Microbiology 1995;141:2123-30.
34. Bigi F, Alito A, Fisanotti JC, Romano MI, Cataldi A. Characterization of a novel Mycobacterium bovis secreted antigen containing PGLTS repeats. Infect Immun 1995;63:2581-6.
35. Schirmbeck R, Reimann J. Targeting of exogenous protein antigens to a novel endosomal processing pathway for class I-restricted presentation (review 57 refs). Behring Inst Mitt 1994;14-22.
36. Kaufmann SH, Ladel CH. Role of T cell subsets in immunity against intracellular bacteria: experimental infections of knock-out mice with Listeria monocytogenes and Mycobacterium bovis BCG (review). Immunobiology 1994;191:509-19.
37. Ashbridge KR, Backstrom BT, Liu HX et al. Mapping of T helper cell epitopes by using peptides spanning the 19-kDa protein of Mycobacterium tuberculosis. Evidence for unique and shared epitopes in the stimulation of antibody and delayed-type hypersensitivity responses. J Immunol 1992;148:2248-55.
38. Ashbridge KR, Booth RJ, Watson JD, Lathigra RB. Nucleotide sequence of the 19kDa antigen gene from Mycobacterium tuberculosis. Nucleic Acids Res 1989;17:1249.
39. Cherayil BJ, Young RA. A 28-kDa protein from Mycobacterium leprae is a target of the human antibody response in lepromatous leprosy. J Immunol 1988;141:4370-5.
40. Young DB, Garbe TR. Lipoprotein antigens of Mycobacterium tuberculosis. Res Microbiol 1991;142:55-65.
41. O'Loan CJ, Pollock JM, Hanna J, Neill SD. Immunoblot analysis of humoral immune responses to Mycobacterium bovis in experimentally infected cattle: early recognition of a 26-kilodalton antigen. Clin Diagn Lab Immunol 1994;1:608-11.
42. Steme JA, Fine PE, Ponnighaus JM, Sibanda F, Munthali M, Glynn JR. Does bacille Calmette-Guerin scar size have implications for protection against tuberculosis or leprosy? Tuber Lung Dis 1996;77:117-23.