Microsatellite instability in tumor and nonneoplastic colorectal cells from hereditary non-polyposis colorectal cancer and sporadic high microsatellite-instable tumor patients

Pathobiology

Volumn 68, Issue 4-5, 2000, Pages 227-231

  Dietmaier, Wolfgang ^a   Gänsbauer, Susanne ^a   Beyser, Kurt ^b   Renke, Birgit ^a   Hartmann, Arndt ^a   Rümmele, Petra ^a   Jauch, Karl Walter ^a   Hofstädter, Ferdinand ^a   Rüschoff, Josef ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b KLINIKUM KASSEL   (Germany)

Author keywords

Colorectal cancer; Hereditary non polyposis colorectal cancer; hMLH1; hMSH2; Immunohistochemistry; Microsatellite instability; Mismatch repair

Indexed keywords

COLORECTAL CANCER; CONFERENCE PAPER; CONTROLLED STUDY; GENE MUTATION; GENETIC HETEROGENEITY; GENOME; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROSATELLITE INSTABILITY; PHENOTYPE; POLYPOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCREENING TEST;

CELL SEPARATION; COLON; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DISSECTION; HUMANS; INTESTINAL MUCOSA; LASERS; MICROSATELLITE REPEATS; RECTUM;

EID: 0034462877     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055928     Document Type: Conference Paper

References (21)

1. Caduff RF, Johnston CM, Svoboda-Newman SM, Poy EL, Merajver SD, Frank TS: Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma. Am J Pathol 1996;148:1671-1678.
2. Katabuchi H, van Rees B, Lambers AR, Ronnett BM, Blazes MS, Leach FS, Cho KR, Hedrick L: Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. Cancer Res 1995;55:5556-5560.
3. Horii A, Han HJ, Shimada M, Yanagisawa A, Kato Y, Ohta H, Yasui W, Tahara E, Nakamura Y: Frequent replication errors at microsatellite loci in tumors of patients with multiple primary cancers. Cancer Res 1994;54:3373-3375.
4. Toyama T, Iwase H, Yamashita H, Iwata H, Yamashita T, Ito K, Hara Y, Suchi M, Kato T, Nakamura T, Kobayashi S: Microsatellite instability in sporadic human breast cancers. Int J Cancer 1996;68:447-451.
5. Peng H, Chen G, Du M, Singh N, Isaacson PG, Pan L: Replication error phenotype and p53 gene mutation in lymphomas of mucosa-associated lymphoid tissue. Am J Pathol 1996;148: 643-648.
6. Izumoto S, Arita N, Ohnishi T, Hiraga S, Taki T, Tomita N, Ohue M, Hayakawa T: Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas. Cancer Lett 1997;112:251-256.
7. Vasen HF, Mecklin JP, Kahn PM, Lynch HT: The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum 1991;34: 424-425.
8. Rodriguez-Bigas MA, Boland CR, Hamilton SR, Henson DE, Jass JR, Khan PM, Lynch H, Perucho M, Smyrk T, Sobin L, Srivastava S: A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting highlights and Bethesda guidelines. J Natl Cancer Inst 1997;89:1758-1762.
9. Dietmaier W, Wallinger S, Bocker T, Kullmann F, Fishel R, Rüschoff J: Diagnostic microsatellite instability: Definition and correlation with mismatch repair protein expression. Cancer Res 1997;57:4749-4756.
10. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN, Srivastava S: A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998;58:5248-5257.
11. Tsopanomichalou M, Kouroumalis E, Ergazaki M, Spandidos DA: Loss of heterozygosity and microsatellite instability in human non-neoplastic hepatic lesions. Liver 1999;19:305-311.
12. Park WS, Pham T, Wang C, Pack S, Mueller E, Mueller J, Vortmeyer A, Zhuang Z, Fogt F: Loss of heterozygosity and microsatellite instability in non-neoplastic mucosa from patients with chronic ulcerative colitis. Int J Mol Med 1998;2:221-224.
13. Cravo ML, Albuquerque CM, Salazar de Sousa L, Gloria LM, Chaves P, Dias Pereira A, Nobre Leitao C, Quina MG, Costa Mira F: Microsatellite instability in non-neoplastic mucosa of patients with ulcerative colitis: Effect of folate supplementation. Am J Gastroenterol 1998;93: 2060-2064.
14. Dietmaier W, Hartmann A, Wallinger S, Heinmöller E, Kerner T, Endl E, Jauch KW, Hofstädter F, Rüschoff J: Multiple mutation analyses in single tumor cells with improved whole genome amplification. Am J Pathol 1999;154: 83-95.
15. Lengauer C, Kinzler KW, Vogelstein B: Genetic instability in colorectal cancers. Nature 1997;386:623-627.
16. Richard SM, Bailliet G, Paez GL, Bianchi MS, Peltomaki P, Bianchi NO: Nuclear and mitochondrial genome instability in human breast cancer. Cancer Res 2000;60:4231-4237.
17. Jackson AL, Chen R, Loeb LA: Induction of microsatellite instability by oxidative DNA damage. Proc Natl Acad Sci USA 1998;95: 12468-12473.
18. Kuismanen SA, Holmberg MT, Salovaara R, de la Chapelle A, Peltomaki P: Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers. Am J Pathol 2000;156:1773-1779.
19. Kuismanen S, Holmberg MT, Salovaara R, Schweizer P, Aaltonen LA, de La Chapelle A, Nystrom-Lahti M, Peltomaki P: Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers. Proc Natl Acad Sci USA 1999;96:12661-12666.
20. Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW, Vogelstein B, Brattain M, Willson J: Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 1995;268:1336-1338.
21. Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC, Perucho M: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997;275:967-969.