The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme a metabolism

Journal of Bacteriology

Volumn 182, Issue 24, 2000, Pages 7007-7013

  Luttik, M A H ^a   Kotter P ^a   Salomons, F A ^a   Van der Klei, I J ^a   Van Dijken, J P ^a   Pronk, J T ^a  

^a DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLISOCITRATE LYASE; AMMONIA; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ISOCITRATE LYASE; MESSENGER RNA; PROPIONYL COENZYME A; PROTEIN ICL2; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CATABOLITE REPRESSION; CELL FRACTIONATION; CELL GROWTH; ENZYME ACTIVITY; ENZYME METABOLISM; FUNGUS GROWTH; GENETIC CODE; GENETIC TRANSCRIPTION; NONHUMAN; NULL CELL; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY;

ACYL COENZYME A; CARBON-CARBON LYASES; CULTURE MEDIA; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GLUCOSE; ISOCITRATE LYASE; MITOCHONDRIA; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS, DNA; SUBCELLULAR FRACTIONS; THREONINE;

FUNGI; SACCHAROMYCES CEREVISIAE; TRIXIS;

EID: 0034461448     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.24.7007-7013.2000     Document Type: Article

References (40)

1. A stretch of positively charged amino acids at the N terminus of Hansenula polymorpha Pex3p is involved in incorporation of the protein into the peroxisomal membrane
2. Identification of D-threo-alpha-methylisocitrate as sterochemically specific substrate for bovine heart aconitase and inhibitor of TPN-linked isocitrate dehydrogenase
3. Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate
4. Serine and threonine catabolism in Saccharomyces cerevisiae: The CHA1 polypeptide is homologous with other serine and threonine dehydratases
5. Effect of 2-methylcitrate on citrate metabolism: Implications for the management of patients with propionic acidemia and methylmalonic aciduria
6. Regulation of carbon metabolism in chemostat cultures of Saccharomyces cerevisiae grown on mixtures of glucose and ethanol
7. The mitochondrial respiratory chain of yeast. Structure and biosynthesis and the role in cellular metabolism
8. Dihydroxyacetone phosphate synthase is localized in the peroxisomal matrix of methanol-grown Hansenula polymorpha
9. The ICL1 gene from Saccaaromyces cerevisiae
10. Cleavage-site motifs in mitochondrial targeting peptides
11. Life with 6000 genes
12. Coordinated regulation of ammonium assimilation and carbon catabolism by glyoxylate in Saccharomyces cerevisiae
13. Molecular genetics of ICL2, encoding a non-functional isocitrate lyase in Saccharomyces cerevisiae
14. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle
15. The CIT3 gene of Saccharomyces cerevisiae encodes a second mitochondrial isoform of citrate synthase
16. Carbon-13 nuclear magnetic resonance study of metabolism of propionate by Escherichia coli
17. The Saccharomyces cerevisiae NDE1 and NDE2 genes encode separate mitochondrial NADH dehydrogenases catalyzing the oxidation of cytosolic NADH
18. Production of pyruvate and succinate by action of isocitrate lyase on α-methylisocitrate
19. Purification and functional characteristics of the pyruvate (monocarboxylate) carrier from baker's yeast mitochondria (Saccharomyces cerevisiae)
20. Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae
21. Enzymatic analysis of the Crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae
22. Propionate metabolism in Saccharomyces cerevisiae: Implications for the metabolon hypothesis
23. Pyruvate metabolism in Saccharomyces cerevisiae
24. The sequence of a 36 kb segment on the left arm of yeast chromosome X identifies 24 open reading frames including NUC1, PRP21 (sPP91), CDC6, CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two homologues to chromosome III genes
25. Structure and regulation of the isocitrate lyase gene from the yeast Saccharomyces cerevisiae
26. Purification and characterization of the branched-chain alpha-ketoacid dehydrogenase complex from Saccharomyces cerevisiae
27. Channeling of TCA cycle intermediates in cultured Saccharomyces cerevisiae
28. A hypothetical cyclic pathway for the metabolism of odd-carbon n-alkanes or propionyl-CoA via seven-carbon tricarboxylic acids in yeasts
29. 7-tricarboxylic acids
30. Propionate oxidation in Escherichia coli: Evidence for the operation of a methylcitrate cycle in bacteria
31. Subcellular localization of the methycitric-acid-cycle enzymes in propionate-metabolism of Yarrowia lipolytica
32. Enhancement of carnitine acetyl-transferase synthesis in alkane-grown cells and propionate-grown cells and propionate-grown cells of Candida tropicalis
33. The two acetyl-coenzyme A synthetases of Saccharomyces cerevisiae differ with respect to kinetic properties and transcriptional regulation
34. Metabolic responses of Saccharomyces cerevisiae CBS8066 and Candida utilis CBS621 upon transition from glucose limitation to glucose excess
35. Colorimetric alcohol assays with alcohol oxidase
36. New heterologous modules for classical or PCR-based gene disruptions in Saccharomyces cerevisiae
37. The Hansenula polymorpha PER1 gene is essential for peroxisome biogenesis and encodes a peroxisomal matrix protein with both carboxy- and amino-terminal targeting signals