Testosterone regulates apoptosis in adult human seminiferous tubules in vitro

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 7, 1997, Pages 2314-2321

  Erkkilä, Krista ^a   Henriksén, Kenth ^b   Hirvonen, Virve ^a   Rannikko, Sakari ^a   Salo, Jaakko ^a   Parvinen, Martti ^b   Dunkel, Leo ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; HORMONAL REGULATION; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; REGULATORY MECHANISM; SEMINIFEROUS TUBULE; TESTOSTERONE RELEASE;

ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; BLOTTING, SOUTHERN; CULTURE TECHNIQUES; DNA FRAGMENTATION; HUMANS; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; SEMINIFEROUS TUBULES; TESTOSTERONE;

EID: 0030877224     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.7.2314     Document Type: Article

References (31)

1. Wyllie AH, Kerr JFR, Currie AR. 1980 Cell death: the significance of apoptosis. Int Rev Cytol. 68:251-306.
2. Arends MJ, Morris RG, Wyllie AH. 1990 Apoptosis: the role of the endonuclease. Am J Pathol. 136:593-608.
3. Ellis RE, Yuan J, Horvitz HR. 1991 Mechanisms and functions of cell death. Annu Rev Cell Biol. 7:663-698.
4. Flemming W. 1887 Neue Beiträge zur Kenntniss der Zelle. 1. Die Kerntheilung bei den Spermatocyten von Salamandra maculosa. Arch Mikrosk Anat Entw Mach. 29:389-463.
5. Oakberg E. 1956 A description of spermatogenesis in the mouse and its use in analysis of the cycle of seminiferous epithelium and germ cell renewal. Am J Anat. 99:391-413.
6. Huckins C. 1978 The morphology and kinetics of spermatogonial degeneration in normal adult rats: an analysis using a simplified classification of germinal epithelium. Anat Rec. 190:905-926.
7. De Rooij DG, Lok D. 1987 Regulation of the density of spermatogonia in the seminiferous epithelium of the Chinese hamster. II. Differentiating spermatogonia. Anat Rec. 217:131-136.
8. Allan DJ, Harmon BV, Roberts SA. 1992 Spermatogonial apoptosis has three morphologically recognizable phases and shows no circadian rhythm during normal spermatogenesis in the rat. Cell Prolif. 25:241-250.
9. Billig H, Furuta I, Rivier C, Tapanainen J, Parvinen M, Hsueh AJW. 1995 Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology. 136:5-12.
10. Sinha Hikim AP, Wang C, Leung A, Swerdloff R. 1995 Involvement of apoptosis in the induction of germ cell degeneration in adult rats after gonadotropin-releasing hormone antagonist treatment. Endocrinology. 136:2770-2775.
11. Henriksen K, Hakovirta H, Parvinen M. 1995 Testosterone inhibits and induces apoptosis in rat seminiferous tubules in a stage-specific manner: in situ quantification in squash preparations after administration of ethane dimethane sulfonate. Endocrinology. 136:3285-3291.
12. Tapanainen JS, Tilly JL, Vihko KK, Hsueh AJ. 1993 Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol. 7:643-650.
13. Shetty J, Marathe GK, Dighe RR. 1996 Specific immunoneutralization of FSH leads to apoptotic cell death of the pachytene spermatocytes and spermatogonial cells in the rat. Endocrinology. 137:2179-2182.
14. Brinkworth MH, Weinbauer GF, Schlatt S, Nieschlag E. 1995 Identification of male germ cells undergoing apoptosis in adult rats. J Reprod Fertil. 105:25-33.
15. Parvinen M, Hecht NB. 1981 Identification of living spermatogenic cells of the mouse by transillumination-phase contrast microscopic technique for 'in situ' analyses of DNA polymerase activities. Histochemistry. 71:567-579.
16. Gross-Bellard M, Oudet P, Chambon P. 1973 Isolation of high-molecular-weight DNA from mammalian cells. Eur J Biochem. 36:32-38.
17. Tilly JL, Hsueh AJW. 1993 Microscale autoradiographic method for qualitative and quantitative analysis of apoptotic DNA fragmentation. J Cell Physiol. 154:519-526.
18. Nantel F, Monaco L, Foulkes NS, et al. 1996 Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature. 380:159-162.
19. Billig H, Furuta I, Hsueh AJW. 1993 Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Endocrinology. 133:2204-2212.
20. Heiskanen P, Billig H, Toppari J, et al. 1996 Apoptotic cell death in the normal and cryptorchid human testis: the effect of human chorionic gonadotropin on testicular cell survival. Pediatr Res. 40:351-356.
21. Munakata S, Hendricks JB. 1993 Effect of fixation time and microwave oven heating time on retrieval of the Ki-67 antigen from paraffin-embedded tissue. J Histochem Cytochem. 41:1241-1246.
22. Troiano L, Fustini MF, Lovato E, et al. 1994 Apoptosis and spermatogenesis: evidence from an in vivo model of testosterone withdrawal in the adult rat. Biochem Biophys Res Commun. 202:1315-1321.
23. Wing T-Y, Christiansen AK. 1982 Morphometric studies on rat seminiferous tubule. Am J Anat. 165:13-25.
24. Johnson L, Lebovitz RM, Samson WK. 1984 Germ cell degeneration in normal and microwave-irradiated rats: potential sperm production rates at different developmental steps in spermatogenesis. Anat Rec. 209:501-507.
25. Kerr JB. 1992 Spontaneous degeneration of germ cells in normal rat testis: assessment of cell types and frequency during the spermatogenic cycle. J Reprod Fertil. 95:825-830.
26. Henriksen K, Kangasniemi M, Parvinen M, Kaipia A, Hakovirta H. 1996 In vitro, follicle-stimulating hormone prevents apoptosis and stimulated deoxyribonucleic acid synthesis in the rat seminiferous epithelium in stage-specific fashion. Endocrinology. 137:2141-2149.
27. Ross MH, Romrell, LJ. 1989 Male reproductive system. In: Ross MH, Romrell LJ, eds. Histology: a text and atlas, 2nd ed. Baltimore: Williams and Wilkins; 603-647.
28. Kerr JB, de Kretser DM. 1981 The cytology of the human testis. In: Burger MD, de Kretser D, eds. The testis. New York: Raven Press; 141-169.
29. Steinberger E. 1991 Hormonal control of mammalian spermatogenesis. Physiol Rev. 51:1-22.
30. Parvinen M. 1982 Regulation of the seminiferous epithelium. Endocr Rev. 3:404-417.
31. Russell LD, Clermont Y. 1977 Degeneration of germ cells in normal, hypophysectomized and hormone treated hypophysectomized rats. Anat Rec. 187: 347-366.