Tolerance induction for solid organ grafts with donor-derived hematopoietic reconstitution

Immunologic Research

Volumn 22, Issue 2-3, 2000, Pages 147-164

  Gandy, K L ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bone marrow; Stem cell; Tolerance; Transplantation

Indexed keywords

ALLOGRAFT; BONE MARROW TRANSPLANTATION; CELL LINEAGE; CONFERENCE PAPER; DONOR; GRAFT FAILURE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC SYSTEM; HISTOCOMPATIBILITY; HUMAN; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; METHODOLOGY; NONHUMAN; ORGAN TRANSPLANTATION; PRIORITY JOURNAL;

ANIMALS; BLOOD DONORS; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOST VS GRAFT REACTION; HUMANS; IMMUNOCOMPROMISED HOST; ORGAN TRANSPLANTATION; SENSITIVITY AND SPECIFICITY; TRANSPLANTATION TOLERANCE; TRANSPLANTATION, HOMOLOGOUS;

EID: 0034448954     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:22:2-3:147     Document Type: Conference Paper

References (120)

1. Use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle
2. Immunogenetic consequences of vascular anastomoses between bovine twins
3. Actively acquired tolerance of foreign cells
4. Quantitative studies on tissue transplatation immunity. III: Actively acquired tolerance
5. Effect of spleen protection on mortality following x-irradiation
6. Modification of irradiation injury in mice and guinea pigs by bone marrow injections
7. Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow
8. Cytological identification of radiation-chimeras
9. Cytotoxic typing antisera for marrow grafting in littermate dogs
10. Successful marrow homograft in the dog after irradiation
11. Autografts of bone marrow in dogs after lethal total-body radiation
12. Marrow transplants in lethally irradiated dogs given methotrexate
13. Marrow grafts by combined marrow and leukocyte infusions in unrelated dogs selected by histocompatibility typing
14. Marrow infusions in dogs given midlethal or lethal irradiation
15. Graft-versus-host disease in dog and man: The Seattle experience
16. What radiation dose for DLA-identical canine marrow grafts?
17. Iso-leuco-anticorps
18. Leucocyte antibodies in sera of pregnant women
19. Skin allograft survival in 238 human subjects: Role of specific relationships at the four sites of the first and the second HLA loci
20. Immunogenetics of consanguineous allografts in man. I. Histocompatibility testing and skin allografts
21. The immunogenicity of human HL-A haplotypes as measured by skin graft survival times and mixed leukocyte reactions
22. Long-term survival after renal transplantation in humans
23. Immunogenetics of consanguineous allografts in man. II. Correlation of renal allografting with HL-A genotyping
24. Analysis of HL-A incompatibility in human renal transplants
25. Homotransplantation of the kidney in the human
26. Quelques essais de greffe rein chez l'homme
27. Experiences with renal homotransplatation in the human: Report of nine cases
28. Successful homotransplantation of the kidney between nonidentical twins
29. Historic landmarks in clinical transplantation: Conclusions from the consensus conference at the University of California, Los Angeles
30. Prevention of genetic anemias in mice by microinjection of normal hematopoietic stem cells into the fetal placenta
31. Adult haematopoietic cells transplanted to sheep fetuses continue to produce adult globins
32. Transplantation of fetal hematopoietic stem cells in utero: The creation of hematopoietic chimeras
33. Hematopoietic chimerism in sheep and nonhuman primates by in utero transplantation of fetal hematopoietic stem cells
34. Tolerance to cardiac allografts induced in utero with fetal liver cells
35. Perinatal induction of immunotolerance to cardiac and pulmonary allografts
36. Donor-derived hematopoietic reconstitution assures in utero tolerance induction
37. Use of homozygous allogeneic bone marrow for induction of tolerance with antilymphocyte serum: Dose and timing
38. Use of low doses of homozygous allogeneic bone marrow cells to induce tolerance with antilymphocyte serum (ALS): Tolerance by intraorgan injection
39. Enhanced survival of canine renal allografts of ALS-treated dogs given bone marrow
40. The effect of anti-lymphocyte serum, fractionated donor bone marrow, and cyclosporine on renal allograft survival in mongrel dogs
41. Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance
42. Effect of selective T cell depletion of host and/or donor bone marrow on lymphopoietic repopulation, tolerance, and graft-vs-host disease in mixed allogeneic chimeras (B10 + B10.D2 - B10)
43. Alloresistance to engraftment of allogeneic donor bone marrow is mediated by an Lyt-2+ T cell in mixed allogeneic reconstitution (C57BL/10Sn + B 10.D2/nSn - C57BL/10Sn)
44. Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD
45. Effects oft cell depletion in radiation bone marrow chimeras. II. Requirement for allogeneic T cells in the reconstituting bone marrow inoculum for subsequent resistance to breaking of tolerance
46. Possible active enhancement of a human cadaver renal allograft with antilymphocyte serum (ALS) and donor bone marrow: Case report of an initial attempt
47. Use of cryopreserved donor bone marrow in cadaver kidney allograft recipients
48. Long-term results of a controlled prospective study with transfusion of donor-specific bone marrow in 57 cadaveric renal allograft recipients
49. Peripheral blood chimerism in renal allograft recipients transfused with donor bone marrow
50. Renal allograft tolerance induced with ATG and donor bone marrow in outbred rhesus monkeys
51. Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow. I. In vivo parameters and immunohistologic evidence suggesting microchimerism
52. Promotion of incompatible allograft acceptance in rhesus monkeys given posttransplant antithymocyte globulin and donor bone marrow. II. Effects of adjuvant immunosuppressive drugs
53. Donor-specific bone marrow infusion after orthotopic liver transplantation
54. Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance
55. Systemic chimerism in human female recipients of male livers
56. Cell migration, chimerism, and graft acceptance
57. Chimerism after liver transplantation for type IV glycogen storage disease and type 1 Gaucher's disease
58. Chimerism and donor-specific nonreactivity 27 to 29 years after kidney allotransplantation
59. Hematolymphoid cell trafficking, microchimerism, and GVH reactions after liver, bone marrow, and heart transplantation
60. Bone marrow augmentation of donor-cell chimerism in kidney, liver, heart, and pancreas islet transplantation
61. Augmentation of chimerism with perioperative donor bone marrow infusion in organ transplant recipients: A 44 month follow-up
62. Effects of donor bone marrow infusion in clinical lung transplantation
63. A clinical trial combining donor bone marrow infusion and heart transplantation: Intermediate-term results
64. Immunologic tolerance to renal allografis after bone marrow transplants from the same donors
65. Tolerance to an HLA-B, DR disparate kidney allograft after bone-marrow transplantation from same donor
66. Renal transplantation without chronic immunosuppression after T cell-depleted, HLA-mismatched bone marrow transplantation
67. Transplantation of a lobe of lung from mother to child following previous transplantation with maternal bone marrow
68. Pediatric lung transplantation and "lessons from Green Surgery"
69. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: The induction of allograft tolerance through mixed lymphohematopoietic chimerism
70. Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD
71. Tolerance of allogeneic heart grafts in mice simultaneously reconstituted with purified allogeneic hematopoietic stem cells
72. Actively acquired tolerance of heterologous antigens
73. Studies on the mechanism of split tolerance in mice
74. Importance of chimerism in maintaining tolerance of skin allografts in mice
75. Mixed allogeneic chimeras prepared by a nonmyeloablative regimen: Requirement for chimerism to maintain tolerance
76. Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation
77. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population
78. Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection
79. Positive and negative selection of alpha-betaTCR+ T cells in thymectomized adult radiation bone marrow chimeras
80. Cure of malignant lymphoma in dogs with peripheral blood stem cell transplantation
81. Increase in circulating stem cells following chemotherapy in man
82. Cyclophosphamide treatment expands the circulating hematopoietic stem cell pool in dogs
83. Comparative effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) on priming peripheral blood progenitor cells for use with autologous bone marrow after high-dose chemotherapy
84. Autologous transplantation with peripheral blood mononuclear cells collected after administration of recombinant granulocyte stimulating factor
85. Transplantation of purified hematopoietic stem cells: Requirements for overcoming the barriers of allogeneic engraftment
86. Fate of chromosome-marked mouse bone marrow cells tranfused into normal syngeneic recipients
87. Proliferation of donor spleen and bone-marrow cells in the spleens and bone marrows of unirradiated and irradiated adult mice
88. Proliferation of donor hematopoietic cells in irradiated and unirradiated host mice
89. Special proliferative sites are not needed for seeding and proliferation of transfused bone marrow cells in normal syngeneic mice
90. Transplantation of chromosomally marked syngeneic marrow cells into mice not subjected to hematopoietic stem cell depletion
91. Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice
92. Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice
93. Transplantation tolerance induced by "mega dose" CD34+ cell transplants
94. Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts
95. Depletion of T-cells with campath-1 and human complement. Analysis of GvHD and graft failure in a multicentre study
96. Treatment of donor bone marrow with monoclonal anti-T-cell antibody complement for the prevention of graft-versus-host disease. A prospective, randomized, double-blind trial
97. Graft rejection following HLA matched T-lymphocyte depleted bone marrow transplantation
98. Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity
99. Enhancement of T-cell-depleted bone marrow allografts in the absence of graft-versus-host disease is mediated by CD8+CD4- and not by CD8-CD4+ thymocytes
100. Donor CD8 cells prevent allogeneic marrow graft rejection in mice: Potential implications for marrow transplantation in humans
101. Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells
102. CD8+TCR+ and CD8+TCR-cells in whole bone marrow facilitate the engraftment of hematopoietic stem cells across allogeneic barriers
103. Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment
104. Immunoregulatory role of CD8 alpha in the veto effect
105. Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: Harnessing graft-versus-leukemia without myeloablative therapy
106. Transplant-lite: Induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies
107. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases
108. Outpatient allografting with minimal myelosuppressive, immunosuppressive conditioning of low dose TBI and postgrafting cyclosporine (CSP) and mycophenolate mofetil (MMF)
109. Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: Full donor T-cell chimerism precedes alloimmune responses
110. Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation
111. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies
112. Nonmyeloablative allogeneic stem cell transplant strategies and the role of mixed chimerism
113. Worldwide thoracic organ transplantation: A report from the UNOS/ISHLT International Registry for Thoracic Organ Transplantation
114. Liver transplantation in the United States from 1987-1998
115. The UNOS scientific renal transplant registry - Ten years of kidney transplants
116. The UNOS scientific renal transplant registry